Colchicine poisoning: the dark side of an ancient drug

Finkelstein, Yaron; Aks, Steven E.; Hutson, Janine R.; Juurlink, David N.; Nguyen, Patricia; Dubnov-Raz, Gal; Pollak, Uri; Koren, Gideon; Bentur, Yedidia

doi:10.3109/15563650.2010.495348

Cited by 487 publications

(523 citation statements)

References 87 publications

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“…The most common side effects of colchicine are nausea, vomiting and diarrhea. It may also cause, although more rarely, fatal multiple organ failure picture including hematologic, cardiac symptoms, neuropathy and myopathy (1). In this case we present a patient developing multiple organ failure and polyneuropathy secondary to colchicine use.…”

Section: Introductionmentioning

confidence: 88%

Kolşisin ile İlişkili Polinöropati ve Multi-Organ Yetmezliği

Dağ¹,

Türkel²,

Gökçe³

2013

tnd

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Sum maryColchicine arrests microtubule assembly and inhibits many cellular functions. This drug is used to treat gout and and Familial Mediterranean Fever. Its gastrointestinal side effects are frequent but more severe adverse effects such as neuropathy and multi-organ failure associated with colchicine are rare. The blood levels of colchicine are dependent on the liver and kidneys. Thus renal or liver failure can result in colchicine toxication. We presented a case of colchicine toxicity, which resulted in multi-organ failure and polyneuropathy.

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Section: Introductionmentioning

confidence: 88%

Kolşisin ile İlişkili Polinöropati ve Multi-Organ Yetmezliği

Dağ¹,

Türkel²,

Gökçe³

2013

tnd

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“…Thus, the quality of life is seriously affected. Improper usage of drugs such as colchicine may also induce multiple complications [18]. Traditional surgery often requires large incisions and does not allow accurate assessment of articular disease severity.…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Controlled Trial to Assess the Efficacy of Arthroscopic Debridement in Combination with Oral Medication Versus Oral Medication in Patients with Gouty Knee Arthritis

et al. 2013

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Gouty knee arthritis refers to a form of inflammatory diseases caused by deposits of needle-like crystals of uric acid in knee joint. The aim of this study was to assess the efficacy and safety of arthroscopic debridement in combination with oral medication versus oral medication alone for the treatment of gouty knee arthritis. A total of 60 patients with gouty knee arthritis were randomized to receive either arthroscopic surgery in combination with oral medication or oral medication alone. Efficacy was assessed with the angle of motion, functions, and visual analog scale (VAS). These indices were measured prior to treatment and at 2, 4, 12, 24, and 48 weeks posttreatment. Surgery-and medication-related complications were observed. Significant differences in flexion and extension of the knee joint, lymphoma scores, and VAS were detected between the two groups at 2, 4, and 12 weeks posttreatment (P<0.05) but not at weeks 24 and 48 posttreatment (P>0.05) . Significant differences in these indices were detected at different time points in each group (P<0.05), except between weeks 24 and 48 (P>0.05). Arthroscopic surgery in combination with oral medication is superior to single oral medication in the flexion and extension of the knee joint, lymphoma scores, and pain relief (VAS) before 24 weeks, although no statistical differences were detected in the efficacy after 24 weeks, and in medicationrelated safety between the two groups. Although arthroscopic debridement cannot replace systemic uric acid-lowering treatments such as medication and dietary control, it is still an effective approach.

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“…Kolşisin intoksikasyonuna bağlı yan etkiler, GİS ve kemik iliği gibi hücre dön-güsünün hızlı olduğu dokularda tübülin polimerizasyonu ve mitoz inhibisyonu sonucu oluşmakta-dır. 13 Stapczynski, kolşisin intoksikasyon belirti ve semptomlarını üç evreye ayırmıştır.…”

Section: Olgu Sunumuunclassified

Colchicine Intoxication Follow-Up in Intensive Care Unit: Case Report

Sevdi¹,

Kerem²,

Akagündüz³

et al. 2017

Turkiye Klinikleri J Anest Reanim

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olşisin, Colchicum autumnale bitkisinden elde edilen ve yağda çözünen bir alkaloiddir.1 Çocuklarda ailevi Akdeniz ateşi (AAA) hastalığı ataklarının önlenmesi ve amiloidoz profilaksisinde; eriş-kinlerde ise akut gut atağı, AAA, Behçet hastalığı ve inflamatuar barsak hastalıklarının tedavisinde kullanılmaktadır.2 Ayrıca primer biliyer siroz, alkolik siroz, psöriyazis, palmar ve plantar püstüloz, nekrotizan vaskülit, sarkoidoz ve sklerodermada da yararlı etkisinin olduğu bilinmektedir. A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Kolşisin; Behçet hastalığı, zehirlenme A AB BS S T TR RA AC CT T Colchicine is a fat-soluble alkaloid which is obtained from colchicum autumnale. It is used in prevention of familial mediterranean fever (FMF) and amyloids prophylaxis in children, and in treatment of acute gut disease, FMF, Behçet's disease and inflammatory intestinal diseases. It is important since it may lead to many cases up to life-threatening gastrointestinal, hematologic changes and cardiogenic shock and affect many organs. After a 39-years-old female patient took 50 colchicine tablets 0,5 mg (totally 25 mg) for suicidal purposes, her abdominal ache and diarrhea symptoms were intensified on the 2 nd day of her follow-up in the intensive care unit (ICU). Her coagulation parameter was deteriorated. When respiratory failure deepened on the 5 th day, mechanical ventilation support was provided through endotracheal intubation. After her hemodynamics and hematologic status were corrected on the 12 th day, she was discharged to the internal medicine's ward. In this article, it was aimed to emphasize the ICU follow-up of the case with colchicine intoxication and the treatment protocol.

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Colchicine poisoning: the dark side of an ancient drug

Abstract: Although colchicine poisoning is relatively uncommon, it is imperative to recognize its features as it is associated with a high mortality rate when missed.

Cited by 487 publications

References 87 publications

Kolşisin ile İlişkili Polinöropati ve Multi-Organ Yetmezliği

Kolşisin ile İlişkili Polinöropati ve Multi-Organ Yetmezliği

A Randomized, Controlled Trial to Assess the Efficacy of Arthroscopic Debridement in Combination with Oral Medication Versus Oral Medication in Patients with Gouty Knee Arthritis

Colchicine Intoxication Follow-Up in Intensive Care Unit: Case Report

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