The nuclear symmetry energy figures crucially in the structure of asymmetric nuclei and, more importantly, in the equation of state (EoS) of compact stars. At present it is almost totally unknown, both experimentally and theoretically, in the density regime appropriate for the interior of neutron stars. Basing on a strong-coupled structure of dense baryonic matter encoded in the skyrmion crystal approach with a topology change and resorting to the notion of generalized hidden local symmetry in hadronic interactions, we address a variety of hitherto unexplored issues of nuclear interactions associated with the symmetry energy, i.e., kaon condensation and hyperons, possible topology change in dense matter, nuclear tensor forces, conformal symmetry, chiral symmetry, etc., in the EoS of dense compact-star matter. One of the surprising results coming from HLS structure that is distinct from what is given by standard phenomenological approaches is that at high density, baryonic matter is driven by renormalization group flow to the "dilaton-limit fixed point" constrained by "mended symmetries". We further propose how to formulate kaon condensation and hyperons in compact-star matter in a framework anchored on a single effective Lagrangian by treating hyperons as the Callan-Klebanov kaon-skyrmion bound states simulated on crystal lattice. This formulation suggests that hyperons can figure in the stellar matter -if at allwhen or after kaons condense, in contrast to the standard phenomenological approaches where the hyperons appear as the first strangeness degree of freedom in matter, thereby suppressing or delaying kaon condensation. In our simplified description of the stellar structure in terms of symmetry energies, which is compatible with that of the 1.97 solar mass star, kaon condensation plays a role of "doorway state" to strange quark matter. stars stable against collapse to black holes, can be addressed in terms of the nuclear symmetry energy ǫ sym . How nuclear forces mediating the strong interactions and controlling the phase structure of multi-baryonic systems enter into the nature of ǫ sym , presumably controlling the fate of compacts stars, is one of the principal themes of our current theoretical research into baryonic matter at high density. This note is a sequel to, and a substantial updating of, previous reports. 1,2On the experimental side, there are broadly two avenues, namely, terrestrial laboratories and space observatories. The heavy-ion collision is one of the terrestrial tools to gain information on how the strong interactions between hadrons (nuclear interaction) are modified with varying densities. In project are laboratories such as KoRIA (Korean Rare Isotope Accelerator, officially called "RAON") and other RIB machines, FAIR (Facility for Antiproton and Ion Reactions) at GSI/Darmstadt, FRIB (Facility for Rare Isotope Beams) at MSU/Michigan and NICA (Nuclotron-based Ion Collider Facility) at JINR/Dubna. They will probe the ranges of temperature up to 50-60 MeV and of density up to (3-4)n 0 (wher...