Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury

Zhou, Ziwei; Li, Ya-dan; Gao, Weiwei; Chen, Jieli; Yue, Shuyuan; Zhang, Jianning

doi:10.4103/1673-5374.213553

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…In this study, the cognitive function was assessed by Morris water maze (MWM). Animals were trained for 3 days in a 50-cm height and 150-cm diameter Morris water maze (ACT-200A, Coulbourn) according to previous descriptions [ 17 ]. The tank was divided into 4 quadrants and filled with water at 20°C.…”

Section: Methodsmentioning

confidence: 99%

Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain

et al. 2018

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BackgroundTraumatic brain injury (TBI) is characterized by cognitive deficits, which was associated with brain oxidative stress and apoptosis. Resveratrol (RSV) is an anti-apoptotic and anti-oxidative. This study aimed to investigate neuroprotective effects and involved molecular mechanisms in TBI.Material/MethodsRSV and p38 inhibitor were administrated to TBI rats. Cognitive deficits were evaluated by Morris water maze assay. Reactive oxygen species (ROS) and apoptosis were detected in rat brains by fluorescent staining. Western blotting was used to assess the phosphorylation of p38 and the expression levels of Nrf2, HO1, and activated caspase-3.ResultsRSV administration attenuated cognitive deficits of TBI rats. The ROS generation and apoptosis in the brain of TBI rats were suppressed by RSV treatment. Moreover, RSV treatment recovered activation of p38/Nrf2/HO1 signaling pathway. The co-administration of p38 inhibitor impaired RSV’s attenuating effects on cognitive deficits, brain apoptosis, and ROS generation.ConclusionsRSV attenuated cognitive deficits of TBI by inhibiting oxidative stress-mediated apoptosis via targeting p38/Nrf2 signaling.

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Section: Methodsmentioning

confidence: 99%

Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain

et al. 2018

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“…From a mechanistic perspective, the effects of DR may be attributed to a combination of trigeminal nerve stimulation, apnea, and peripheral vasoconstriction (Fig 10). While physical activities such as running and swimming can induce an angiogenic response, these interventions necessitate a certain level of physical exertion to achieve efficacy [15,51,52,[66][67][68][69]. In human subjects, only high-intensity physical exercise, not moderate-intensity exercise, promotes an elevation in VEGF and nitric oxide, a key vasodilator [70].…”

Section: Discussionmentioning

confidence: 99%

Intrinsic diving reflex enhances cognitive performance by alleviating microvascular dysfunction in vascular cognitive impairment

Tambo,

Powell,

Wadolowski

et al. 2024

Preprint

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Vascular cognitive impairment (VCI) stands as the second-most prominent contributor to cognitive decline, lacking efficacious interventions. Chronic cerebral hypoperfusion (CCH) triggers microvascular dysfunction, which plays a critical role in VCI pathophysiology, emerging as a pivotal therapeutic target. While interventions addressing facets of microvascular dysfunction like angiogenesis and blood-brain barrier functionality show promise, the evaluation of microvascular constriction, another key component, remains unexplored. The diving reflex (DR) represents an oxygen-conserving response, characterized by robust vasodilation and potentially also inducing angiogenesis. In this investigation, we studied DR's functionality and underlying mechanisms within a rat bilateral common carotid artery occlusion induced CCH model. Remarkably, progressive hippocampal microvascular constriction exhibited strong correlations with short-term memory impairment during both early (R2=0.641) and late phases (R2=0.721) of CCH. Implementation of DR led to a significant reduction in microvascular constriction within the hippocampus (~2.8-fold) and striatum (~1.5-fold), accompanied by enhanced vasodilatory capacity and heightened expression of vasoactive neuropeptides. Furthermore, DR attenuated microvascular degeneration across various brain subregions affected by CCH, concomitant with increased levels of multiple angiogenic factors. The reinforced microvascular integrity facilitated by DR corresponded with significantly improved short-term recognition memory and long-term spatial memory functions observed during the late phase of CCH. The comprehensive and synergistic effects of DR on various aspects of microvascular function and cognitive preservation highlight its potential as a disease-modifying therapeutic strategy in VCI.

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“…Холод вважається найсильнішим анальгетиком. Плавання в холодній воді (ПХВ) може послабити стрес-реакцію [3][4][5][6]. Щотижневе плавання у відкритій (холодній) воді призводить до поліпшення настрою після кожного запливу [3,7], стійкого та поступо-вого зменшення симптомів депресії, а потім припинення прийому ліків [7].…”

Section: вступunclassified

“…Відомо, що стрес викликає активацію гіпоталамо-гіпофізарно-адренокортикальної осі і завершується вивільненням адреналіну [15]. Слід зазначити, що ПХВ упродовж 3 хв при 4°C покращує когнітивні функції у щурів [6]. Вважається, що ці, спричинені стресом, поліпшення нейрокогнітивних функцій опосередковані активацією симпатичної нервової системи, посиленням кровотоку та синаптичного вивільнення норадреналіну у головному мозку.…”

Section: результати та їх обговоренняunclassified

Stimulation of the Proteinaseproteinase Inhibitor System as a Result of Immersion Hypothermia [

Samokhina¹,

Lomako²

2022

Fiziol Zh

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The effect of immersion hypothermia (IН) on proteolysis activity in adult male rats, which was performed at 0 °C for 5 min in the “forced swimming” test, studied; the body temperature decreased to 27.5 ± 0.5°C. In blood serum and non-nuclear fractions of homogenates of cerebral cortex, hypothalamus, cerebellum, brainstem, lungs, heart, liver and kidneys tissues were determined the total proteinase activity (TPA), non-trypsin-like proteinases (NTPs), such as chymase, prostate-specific antigen, partially tonin, kallikrein rK9, as well as trypsin-inhibitory activity of α-1-proteinase inhibitor (α-1-PI), α-2-macroglobulin (α-2-MG) by highly sensitive (10-9–10-10 g) enzymatic methods. It is noted that IH led to the TPA increase in all studied tissues (4-84 times), which corresponds to the psycho-emotional effects and the phenomenon of hormesis. After 24 h, TPA decreased, remaining above the control level, and in the kidneys increased further (90 times). NTLP activity as a result of IH increased in blood serum and cerebellum, decreased in the hypothalamus, and after 24 h increased further in serum (7 times), cerebellum, and heart. The activity of α-1-PI also increased in the brainstem, lungs, heart and kidneys, and decreased after 24 h in serum below the control level, and in the brainstem remained high, protecting against proteolytic attack. The activity of α-2-MG increased in the hypothalamus, heart, and cerebral cortex, maximum in the brainstem (2-5 times), and after 24 h - more significantly (24 times), but there were no changes in the cerebellum, where its initial level is the biggest. Thus, the development of IG as a result of swimming in cold water for 5 min at 0oC has a stimulating effect on the body and leads to a significant activation of the reactions of limited proteolysis.

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Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury

Cited by 6 publications

References 43 publications

Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain

Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain

Intrinsic diving reflex enhances cognitive performance by alleviating microvascular dysfunction in vascular cognitive impairment

Stimulation of the Proteinaseproteinase Inhibitor System as a Result of Immersion Hypothermia [

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