Colistin, mechanisms and prevalence of resistance

Bialvaei, Abed Zahedi; Kafil, Hossein Samadi

doi:10.1185/03007995.2015.1018989

Cited by 371 publications

(286 citation statements)

References 130 publications

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“…After its discovery in 1947, colistin was used in Japan and Europe during the 1950s (29). Then, after its approval by the U.S. FDA in 1959, colistimethate (CMS), the inactive prodrug of colistin, replaced colistin for parenteral administration (29).…”

Section: Use Of Colistin In Human and Veterinary Medicine Use In Humamentioning

confidence: 99%

“…Then, after its approval by the U.S. FDA in 1959, colistimethate (CMS), the inactive prodrug of colistin, replaced colistin for parenteral administration (29). Colistin and CMS have been used widely for decades for treatment of infections caused by Gramnegative bacteria.…”

Section: Use Of Colistin In Human and Veterinary Medicine Use In Humamentioning

confidence: 99%

“…Although polymyxins currently retain significant in vitro activity against most Gramnegative organisms, resistance to these antibiotics is increasingly being reported among clinical isolates (29,182).…”

Section: Epidemiology Of Resistance To Polymyxins General Epidemiologmentioning

confidence: 99%

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Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

2017

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SUMMARY Polymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug-resistant Gram-negative bacteria. Colistin and polymyxin B are being seriously reconsidered as last-resort antibiotics in many areas where multidrug resistance is observed in clinical medicine. In parallel, the heavy use of polymyxins in veterinary medicine is currently being reconsidered due to increased reports of polymyxin-resistant bacteria. Susceptibility testing is challenging with polymyxins, and currently available techniques are presented here. Genotypic and phenotypic methods that provide relevant information for diagnostic laboratories are presented. This review also presents recent works in relation to recently identified mechanisms of polymyxin resistance, including chromosomally encoded resistance traits as well as the recently identified plasmid-encoded polymyxin resistance determinant MCR-1. Epidemiological features summarizing the current knowledge in that field are presented.

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Section: Use Of Colistin In Human and Veterinary Medicine Use In Humamentioning

confidence: 99%

Section: Use Of Colistin In Human and Veterinary Medicine Use In Humamentioning

confidence: 99%

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Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

2017

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“…ficacy of the past chemotherapy regimens is important as the same as detecting errors in past treatments (62,63). However, the absence of a comprehensive surveillance network and inadequacy of reliable prevalence studies in Iran make it difficult to evaluate the true extent of multidrugresistant tuberculosis in the country (56).…”

Section: Surveillance Systemmentioning

confidence: 99%

Challenges of Tuberculosis in Iran

Bialvaei

Asgharzadeh

Aghazadeh

et al. 2017

Jundishapur J Microbiol

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“…The risk of resistance has also been accelerated due to overuse of the antibiotics. The most common example of overuse is by the people suffering from common cold and cough using antibiotics contributing to the development of antimicrobial resistance [1][2][3][4][5][6] .…”

mentioning

confidence: 99%

Teixobactin: A Powerful Tool for Combating Resistant Strains

Rawal¹,

Butani²

2016

pharmaceutical-sciences

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Resistance to antibiotics has grown out to be a serious health concern. Despite this serious health crisis, no new antibiotics have been discovered since the last 30 years. A new ray of hope in the form of teixobactin has come out of the dark, which could demonstrate the potential to be effective in countering resistance. This new antibiotic has an interesting mechanism of action against bacteria. The discovery of this wonderful compound has evolved as a major breakthrough especially in this era of antibiotic catastrophe. This review article highlights various facets of teixobactin that include chemistry, mode of action, in vitro and in vivo activities. Though the compound has not yet undergone clinical studies, its effect on mice models has given hope for overpowering resistance. This review attempts to provide information about teixobactin and its potential for fighting as antibiotic resistance.

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Colistin, mechanisms and prevalence of resistance

Abstract: There is a critical need for effective infection prevention and control measures and strict use of antibiotics in the world to control the rise and spread of colistin resistance.

Cited by 371 publications

References 130 publications

Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

Challenges of Tuberculosis in Iran

Teixobactin: A Powerful Tool for Combating Resistant Strains

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