Collagen-based scaffolds: An auspicious tool to support repair, recovery, and regeneration post spinal cord injury

Mneimneh, Amina Tarek; Mehanna, Mohammed M.

doi:10.1016/j.ijpharm.2021.120559

Cited by 32 publications

(24 citation statements)

References 138 publications

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“…The CHS layer mechanically strengthened the catheter, while the collagen layer provided a scaffold for cells supporting axon extension, and the conduit properly induced the axonal extension of the neuron cells in the conduit direction using the cellular support from the cells in the conduit [186]. To help patients achieve functional recovery as much as possible, marine biomaterials in scaffolds are mainly functionalized to improve their binding specificity, with different ligands and compounds such as growth factors and neurotrophic factors, or seeded with different cells such as mesenchymal cells or neural stem cells [187]. In conclusion, these marine biomaterials can effectively support nerve repair and regeneration, but the optimization of nerve function recovery remains to be further studied.…”

Section: Nerve Tissue Engineeringmentioning

confidence: 99%

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Zhang

Liang

et al. 2022

Marine Drugs

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Oceans have vast potential to develop high-value bioactive substances and biomaterials. In the past decades, many biomaterials have come from marine organisms, but due to the wide variety of organisms living in the oceans, the great diversity of marine-derived materials remains explored. The marine biomaterials that have been found and studied have excellent biological activity, unique chemical structure, good biocompatibility, low toxicity, and suitable degradation, and can be used as attractive tissue material engineering and regenerative medicine applications. In this review, we give an overview of the extraction and processing methods and chemical and biological characteristics of common marine polysaccharides and proteins. This review also briefly explains their important applications in anticancer, antiviral, drug delivery, tissue engineering, and other fields.

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Section: Nerve Tissue Engineeringmentioning

confidence: 99%

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Zhang

Liang

et al. 2022

Marine Drugs

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“…Spinal cord injury (SCI) is a perplexing traumatic disease that often leads to permanent disability, as well as motor and sensory impairments [ 1 ]. Statistics show that about 2.5 million patients are suffering from SCI in the world, with approximately 130,000 newly diagnosed cases reported each year [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate the repair of spinal cord injury via the miR-29b-3p/PTEN/Akt/mTOR axis

Xiao

Rong

et al. 2021

Cell Death Discov.

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Spinal cord injury (SCI) is a salient traumatic disease that often leads to permanent disability, and motor and sensory impairments. Human umbilical cord mesenchymal stem cells (HucMSCs) have a wide application prospect in the treatment of SCI. This study explored the repair effect of HucMSCs-derived extracellular vesicles (HucMSCs-EVs) on SCI. HucMSCs and HucMSCs-EVs were cultured and identified. The rat model of SCI was established, and SCI rats were treated with HucMSCs-EVs. The motor function of SCI rats and morphology of spinal cord tissues were evaluated. Levels of NeuN, GFAP, and NF200 in spinal cord tissues were detected and cell apoptosis was measured. SCI rats were treated with EVs extracted from miR-29b-3p inhibitor-transfected HucMSCs. The downstream gene and pathway of miR-29b-3p were examined. HucMSCs-EVs-treated rats showed obvious motor function recovery and reduced necrosis, nuclear pyknosis, and cavity. HucMSCs-EVs alleviated spinal cord neuronal injury. miR-29b-3p was poorly expressed in SCI tissues, but highly expressed in EVs and SCI rats treated with EVs. miR-29b-3p targeted PTEN. Inhibition of miR-29b-3p or overexpression of PTEN reversed the repair effect of EVs on SCI. EVs activated the AKT/mTOR pathway via the miR-29b-3p/PTEN. In conclusion, HucMSCs-EVs reduced pathological changes, improved motor function, and promoted nerve function repair in SCI rats via the miR-29b-3p/PTEN/Akt/mTOR axis.

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“…In spinal cord regeneration, biomaterial scaffolds can be employed to refurbish the continuity of the injured site and ensure a suitable environment for tissue repair, axonal regeneration, and vascularization [83]. Both natural and synthetic biomaterials have been explored for designing adequate structures for restoring neurological function.…”

Section: Biomaterials Scaffoldsmentioning

confidence: 99%

Novel Strategies for Spinal Cord Regeneration

Costăchescu

Niculescu

Dabija

et al. 2022

IJMS

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A spinal cord injury (SCI) is one of the most devastating lesions, as it can damage the continuity and conductivity of the central nervous system, resulting in complex pathophysiology. Encouraged by the advances in nanotechnology, stem cell biology, and materials science, researchers have proposed various interdisciplinary approaches for spinal cord regeneration. In this respect, the present review aims to explore the most recent developments in SCI treatment and spinal cord repair. Specifically, it briefly describes the characteristics of SCIs, followed by an extensive discussion on newly developed nanocarriers (e.g., metal-based, polymer-based, liposomes) for spinal cord delivery, relevant biomolecules (e.g., growth factors, exosomes) for SCI treatment, innovative cell therapies, and novel natural and synthetic biomaterial scaffolds for spinal cord regeneration.

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Collagen-based scaffolds: An auspicious tool to support repair, recovery, and regeneration post spinal cord injury

Cited by 32 publications

References 138 publications

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Characteristics of Marine Biomaterials and Their Applications in Biomedicine

Human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate the repair of spinal cord injury via the miR-29b-3p/PTEN/Akt/mTOR axis

Novel Strategies for Spinal Cord Regeneration

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