Collagen-targeted tumor-specific transepithelial penetration enhancer mediated intravesical chemoimmunotherapy for non-muscle-invasive bladder cancer

Li, Guangzhi; Tao, Tao; Deng, Dashi; Zhang, Shaohua; Chao, Yu; Dai, Yizhi; Li, Yuqing; Tao, Ran; Yuan, Simin; Liu, Zhuang; Wu, Song

doi:10.1016/j.biomaterials.2022.121422

Cited by 27 publications

(22 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The BC perfusion platform effectively promoted the curative effect of chemotherapy and IT. [100] We can draw a conclusion from the above studies that nanotechnology combined with IT is feasible and effective for BC. However, how to solve the problem of immune response design based on nanotechnology, the integration of immune adjuvants and nanomaterials, the precise control of immunological checkpoints, the precise targeting of nanodrug delivery systems, and the relatively high mutation rate of BC cause a low immune response rate remain unknown.…”

Section: Immunotherapymentioning

confidence: 84%

“…They have several advantages, including a good chemical stability, excellent biocompatibility, passive targeting ability, large specific surface area, good thermal stability, high drug loading, and so on. [130] PLZ4@SeD [84] DOX-PS [85] SeDs [87] Thiolated MSN NPs [131] PAMAM-modified MSNPs [132] FA-TMLs@MNPs-GNRs-DOX [135] LP-gel [148] PLL-P(LP-co-LC) [149] Ur-PDA NC [154] NG/HCPT [155] OEGMA-PTX@Ce6 [156] SS CB GB [157] PEG-PAMAM NPs [160] IONP-HA@Gel [168] KP372-1 [86] Cy3-labeled 293T-R-Fe@OA [174] RT HSA-MnO 2 -CQ [92] CDT AgNPs [125] CONPs [133] nZnO [134] IT IR775@Met@Lip [96] MPDIα W [97] 522NP [98] AB680@EMVs-aPDL1 [99] PGFCS [100] CWS-NP [145] CWS-Nano-CL [146] CWS-FPL [147] Fe 3 O 4 @Chl/Fe CNPs [137] GT siRNA@CS-HAD [102] UMND [103] HNTs/siRNA [104] CRISPR-Cas13a/liposome systems [105] siNrf GCD [164] KDM6A-mRNA NPs [106] SCNTs/si-circPRMT5 [143] PTT Fe 3 O 4 @PDA-VCA-FA SPs [67] HAPO-1048 [112] BBTD+GA/PEG-RGD [113] Cu 2-X Se [128] HA-IR780 NP…”

Section: Nonmetallic Oxide Nanomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Designing Intelligent Nanomaterials to Achieve Highly Sensitive Diagnoses and Multimodality Therapy of Bladder Cancer

Chen

et al. 2023

Small Methods

View full text Add to dashboard Cite

Bladder cancer (BC) is among the most common malignant tumors of the genitourinary system worldwide. In recent years, the rate of BC incidence has increased, and the recurrence rate is high, resulting in poor quality of life for patients. Therefore, how to develop an effective method to achieve synchronous precise diagnoses and BC therapies is a difficult problem to solve clinically. Previous reports usually focus on the role of nanomaterials as drug delivery carriers, while a summary of the functional design and application of nanomaterials is lacking. Summarizing the application of functional nanomaterials in high‐sensitivity diagnosis and multimodality therapy of BC is urgently needed. This review summarizes the application of nanotechnology in BC diagnosis, including the application of nanotechnology in the sensoring of BC biomarkers and their role in monitoring BC. In addition, conventional and combination therapies strategy in potential BC therapy are analyzed. Moreover, different kinds of nanomaterials in BC multimodal therapy according to pathological features of BC are also outlined. The goal of this review is to present an overview of the application of nanomaterials in the theranostics of BC to provide guidance for the application of functional nanomaterials to precisely diagnose and treat BC.

show abstract

Section: Immunotherapymentioning

confidence: 84%

Section: Nonmetallic Oxide Nanomaterialsmentioning

confidence: 99%

Designing Intelligent Nanomaterials to Achieve Highly Sensitive Diagnoses and Multimodality Therapy of Bladder Cancer

Chen

et al. 2023

Small Methods

View full text Add to dashboard Cite

show abstract

“…PNPs nanoparticles not only successfully reduced cervical tumors but also actively help in various tumor inhibition that is provided in Table 2 . 61 62 63 64 65 66 67 68 69 70 71 72 73 …”

Section: Application In Cancer Nmsmentioning

confidence: 99%

Protein-Caged Nanoparticles: A Promising Nanomedicine Against Cancer

Mohanty

Park

2023

Chonnam Med J

View full text Add to dashboard Cite

Cancer is a severe threat to human wellness. A broad range of nanoparticles (NPs) have been developed to treat cancer. Given their safety profile, natural biomolecules such as protein-based NPs (PNPs) are promising substitutes for synthetic NPs that are currently used in drug delivery systems. In particular, PNPs have diverse characteristics and are monodisperse, chemically and genetically changeable, biodegradable, and biocompatible. To promote their application in clinical settings, PNPs must be precisely fabricated to fully exploit their advantages. This review highlights the different types of proteins that can be used to produce PNPs. Additionally, the recent applications of these nanomedicines and their therapeutic benefits against cancer are explored. Several future research directions that can facilitate the clinical application of PNPs are suggested.

show abstract

“…Pirabucin as chemotherapeutic agent and IL‐12 as immune stimulator were loaded and led to chemoimmunotherapy in bladder cancer (in vitro and in vivo). 154 …”

Section: Nanoplatforms In Immunotherapymentioning

confidence: 99%

(Nano)platforms in bladder cancer therapy: Challenges and opportunities

Ashrafizadeh

Zarrabi

Karimi‐Maleh

et al. 2022

Bioengineering & Transla Med

View full text Add to dashboard Cite

Urological cancers are among the most common malignancies around the world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for the treatment of bladder cancer although its prognosis remains unfavorable. It is perceived that treatment of bladder cancer depends on an interdisciplinary approach combining biology and engineering. The nanotechnological approaches have been introduced in the treatment of various cancers, especially bladder cancer. The current review aims to emphasize and highlight possible applications of nanomedicine in eradication of bladder tumor. Nanoparticles can improve efficacy of drugs in bladder cancer therapy through elevating their bioavailability. The potential of genetic tools such as siRNA and miRNA in gene expression regulation can be boosted using nanostructures by facilitating their internalization and accumulation at tumor sites and cells. Nanoparticles can provide photodynamic and photothermal therapy for ROS overgeneration and hyperthermia, respectively, in the suppression of bladder cancer. Furthermore, remodeling of tumor microenvironment and infiltration of immune cells for the purpose of immunotherapy are achieved through cargo‐loaded nanocarriers. Nanocarriers are mainly internalized in bladder tumor cells by endocytosis, and proper design of smart nanoparticles such as pH‐, redox‐, and light‐responsive nanocarriers is of importance for targeted tumor therapy. Bladder cancer biomarkers can be detected using nanoparticles for timely diagnosis of patients. Based on their accumulation at the tumor site, they can be employed for tumor imaging. The clinical translation and challenges are also covered in current review.

show abstract

Collagen-targeted tumor-specific transepithelial penetration enhancer mediated intravesical chemoimmunotherapy for non-muscle-invasive bladder cancer

Cited by 27 publications

References 29 publications

Designing Intelligent Nanomaterials to Achieve Highly Sensitive Diagnoses and Multimodality Therapy of Bladder Cancer

Designing Intelligent Nanomaterials to Achieve Highly Sensitive Diagnoses and Multimodality Therapy of Bladder Cancer

Protein-Caged Nanoparticles: A Promising Nanomedicine Against Cancer

(Nano)platforms in bladder cancer therapy: Challenges and opportunities

Contact Info

Product

Resources

About