Collecting duct carcinoma: A rare malignancy

Abstract

A 45-years old man complained of hematuria, and subsequent examination and ultrasonography revealed a mass in the left kidney. Nephrectomy was performed and macroscopically an ill-defined pale-cream, irregular mass was identified which occupied predominantly the renal medulla. Histopathologic examination showed slit like tubular ducts lined by atypical cuboidal to polygonal cells and a marked desmoplastic stromal reaction. The diagnosis of collecting duct carcinoma was made. Patient is now doing well after 11 months of follow up.

Unique Transcriptomic Profile of Collecting Duct Carcinomas Relative to Upper Tract Urothelial Carcinomas and other Kidney Carcinomas

“…First, we demonstrate that CDC is molecularly distinct from other RCC subtypes, with a unique gene expression signature. In addition, contrary to putative origins in the cells of the distal nephrons 1 2 3 , our data suggest that CDC might originates from the DCT of the nephron, which is the segment between the proximal tubules and the distal part of the nephron. Histologically, the cells that form the DCT are located in the vicinity of glomeruli, which might explain the similarity between CDC and the glomeruli expression profils; however, this correlation was less important than that with the cells of the DCT.…”

“…Collecting duct carcinoma (CDC) is a rare subtype of renal cell carcinoma (RCC) that is thought to arise from the principal cells in the distal part of the collecting ducts 1 2 3 . CDC is often considered lethal because it presents in an advanced stage in up to 54% of cases 1 4 .…”

Multidetector CT imaging features of invasive renal parenchyma urothelial carcinoma

“…Renal cell carcinomas .3 cm often contain intratumoral necrosis, haemorrhage, calcifications and are usually of the clear cell variety. 19 Although commonly homogeneous, when poorly differentiated, papillary renal cell carcinomas 20 can have necrosis and cystic change and, in such a situation, may appear heterogeneous. In our study, there was evidence of calcification in 6 (20.7%) patients, which is linear compared with the stippled calcification seen in cortical renal cell carcinomas.…”

Cystic low-grade collecting duct renal carcinoma with liver compression — A challenging diagnosis and therapy: A case report

“…Collecting duct carcinoma (CDC), also known as carcinoma of the collecting ducts of Bellini, comprises fewer than 1% of malignant renal tumors[ 1 , 2 ]. It originates from the collecting duct epithelium, which is located in the renal medulla[ 3 ].…”

“…Microscopically, it has a tubular or tubulopapillary architecture[ 1 , 4 , 10 ]. The World Health Organization established major criteria for diagnosing CDC, which is a diagnosis of exclusion.…”