Collecting-Duct Carcinoma of the Kidney with Prominent Signet Ring Cell Features

Abstract

We report a case in a 74-year-old woman of collecting-duct carcinoma of the kidney with prominent signet ring cell features. Grossly, the tumor measured 5.5 cm in greatest dimension, occupied the entire upper pole of the kidney, and was well circumscribed. Microscopically, it displayed a predominant tubulopapillary pattern of growth with a hyalinizing stroma. The tumor tubules were lined by a single layer of cells with large, pleomorphic nuclei, some of which had a hobnail appearance. Large intracytoplasmic vacuoles with compression of nuclei (signet ring cells) were present throughout the tumor. Alcian blue, mucicarmine, and periodic acid-Schiff stains failed to identify intracellular mucin or glycogen in the signet ring cells. Enlarged cells with intracytoplasmic vacuoles were also noted in the adjacent collecting ducts. The tumor cells were immunohistochemically positive for cytokeratin including cytokeratin 7, CAM 5.2, AE1/3, and 34␤E12, vimentin, peanut lectin agglutinin, and Ulex europaeus agglutinin. Electron microscopy revealed that the intracytoplasmic vacuoles were due to intracellular edema. To the best of our knowledge, this is the first reported case of renal collecting-duct carcinoma with prominent signet ring cell features.

RETRACTED ARTICLE: Collecting duct carcinoma of the kidney: a clinicopathological study of five cases

“…Cancer cell have positive expressions of CK (AE1/AE3), CK7, CK19, EMA, vimentin, CK34BE12, PNA and ulex europeus agglutinin (UEA), and negative expression of CD10 and CK20. Combination of CK34BE12 and PNA is able to detect 90% of CDC [24]. The results from pathological and immunohistochemical examinations are the important basis for the diagnosis of CDC and for differentiating it from other types of kidney cancer.…”

Collecting duct carcinoma of the kidney: A case report

“…Positive immunohistochemical staining for CK19, CK7, 34βE12 and vimentin has been previously reported to support the diagnosis of CDC (17). In addition, a previous study demonstrated that the CDC cells also express EMA, peanut lectin agglutinin and Ulex europaeus agglutinin 1 (18). In the present study, immunohistochemical analysis demonstrated that the tumor cells were strongly positive for EMA and CK7, while they reacted focally with vimentin.…”

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

“…Breast [3] Large bowel [4] Appendix [5] Bladder, ureter, and pelvis [6] Ampulla of Vater [7] Esophagus [8] Prostate [9] Lung [10] Salivary glands [11] Sinonasal tract [12] Uterine cervix [13] Uterine corpus [14] Ovary (questionable) [15] Other neoplastic conditions Malignant lymphoma [16] Malignant melanoma [17] Basal cell carcinoma of skin [18] Squamous cell carcinoma of skin [19] Stromal tumor of ovary [20] Chondrosarcoma [21] Ependymoma [22] Malignant mesothelioma [23] Meningioma [24] Collecting duct carcinoma of kidney [25] Urothelial carcinoma of renal pelvis with collagenous spherulosis [26] Follicular adenoma and carcinoma of thyroid [27] Salivary gland adenoma [28] Pituitary adenoma [29] Carcinoid tumor of gallbladder [30] Pancreatic endocrine neoplasm [31] GIST [32] Peutz-Jeghers polyps [33] Epithelioid leiomyoma [34] Gastric schwannoma [35] Testicular seminoma [36] Nonneoplastic conditions Inflammatory/necrotizing conditions of gastrointestinal tract and gallbladder [33,[37][38][39][40][41][42][43]…”