Collision Tumor of the Ovary Involving Sertoli-Leydig Cell Tumor and High-Grade Serous Carcinoma—Report of the First Case

Omo-Ogboi, Allen C; Deavers, Michael T.; Schmeler, Kathleen M.; Tandon, Nidhi

doi:10.1097/pgp.0000000000000896

Cited by 3 publications

(21 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…Approximately 90% of patients can be detected in the early stages of the disease, with less than 3% presenting with extra-ovarian dissemination and a small number of patients with other combined ovarian lesions. [11,12] Most patients have the opportunity to choose a surgical option that preserves reproductive function after early diagnosis, and testosterone levels generally decrease rapidly to normal after tumor removal and patients are able to regain their femininity quickly. [5] Imaging ancillary examinations are very important in diagnosis, and ultrasonography is a noninvasive, convenient, efficient, and mature examination modality that has become the preferred method for adnexal tumor diagnosis because of its high sensitivity, good acceptability, and low cost.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound examination assisted clinical diagnosis of Leydig cell tumor of ovary: An extremely rare case report

Chen

Li²,

Fu³

et al. 2022

Medicine

View full text Add to dashboard Cite

Introduction: Leydig cell tumor (LCT) is a sex cord-stromal tumor, which is a clinically rare ovarian tumor. It is characterized by endocrine hormonal changes and usually occurs in postmenopausal women. Patient concerns: We report the clinical case of a 38-year-old female of childbearing age with LCT of the right ovary who presented with significantly decreased menstrual flow and elevated androgen levels, with persistent hypoechoic areas in the ovary as demonstrated by transvaginal ultrasound. Diagnosis: The transvaginal ultrasound suggested the presence of a hypoechoic area in the right ovary with elevated androgens, interstitial tumor of the ovarian sex cord may be considered. Interventions: The patient underwent laparoscopic right adnexectomy. Outcomes: Postoperative pathology confirmed the morphology and immunohistochemistry of the right adnexa consistent with LCT, and no areas of malignant transformation were found on multiple sections of the surgical specimen. The patient had normal androgen levels at postoperative day 2, day 45 and month 3. There was no sign of recurrence. Conclusion: This case suggests that when women of childbearing age have abruptly decreased menstrual flow with increased testosterone, clinicians should pay attention to intra-ovarian occupying lesions and consider the possibility of LCT. In such cases, ultrasound examination can determine the presence, location, shape and size of occupying ovarian lesions and play an important role in the diagnosis of condition.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ultrasound examination assisted clinical diagnosis of Leydig cell tumor of ovary: An extremely rare case report

Chen

Li²,

Fu³

et al. 2022

Medicine

View full text Add to dashboard Cite

show abstract

“…Majority of paediatric Sertoli-Leydig cell tumours are moderately differentiated or poorly differentiated, concur with DICER1 syndrome and frequently display heterologous elements or retiform tumour configuration. Histological categorization of neoplasms with enhanced tumour grade appears challenging [1,2].…”

Section: Guest Editorialmentioning

confidence: 99%

“…Well differentiated tumefaction exhibits distinctive Sertoli cell and Leydig cell components. Moderately differentiated or minimally differentiated neoplasms appear devoid of well-formed Sertoli cell tubules with scant Leydig cells [1,2].…”

Section: Guest Editorialmentioning

confidence: 99%

See 1 more Smart Citation

Cylinders and Assemblage- Sertoli-Leydig Cell Tumour -Ovary

Bajaj

2022

GJORM

View full text Add to dashboard Cite

Sertoli-Leydig cell tumour is an exceptionally discerned, ovarian neoplasm composed of sex cord or Sertoli cells admixed with stromal component expounded by Leydig cells. Sertoli-Leydig cell tumour may occur in association with DICER1 syndrome or emerge as a sporadic phenomenon. Sertoli-Leydig cell tumour manifests as well differentiated, moderately differentiated or intermediate grade and poorly differentiated neoplasms. Additionally, categories such as Sertoli-Leydig cell tumour with heterologous elements or retiform variant of Sertoli-Leydig cell tumour may be expounded. Majority of paediatric Sertoli- Leydig cell tumours are moderately differentiated or poorly differentiated, concur with DICER1 syndrome and frequently display heterologous elements or retiform tumour configuration. Histological categorization of neoplasms with enhanced tumour grade appears challenging.

show abstract

Collision Tumor of the Ovary: Adult Granulosa Cell Tumor and Mesonephric-like Adenocarcinoma

Lee,

Alam,

Kim

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Collision tumors of the ovaries are rare, with only a few reports in the literature. Adult granulosa cell tumors are a relatively common primary tumor component of previously reported collision tumors. The combination of serous and mucinous tumors with adult granulosa cell tumors has been reported in several cases. On the other hand, mesonephric-like adenocarcinomas are rare neoplasms that commonly arise in the uterine corpus and ovaries. In this report, we present the case of a collision tumor composed of an adult granulosa cell tumor and mesonephric-like adenocarcinoma of the ovary in a 63-year-old woman. The initial magnetic resonance imaging findings showed a cystic mass with an internal hemorrhage, which suggested an adult granulosa cell tumor, and a solid mass with different enhancements. Microscopically, the tumor had two distinct components: An adult granulosa cell tumor and a mesonephric-like adenocarcinoma. Recognizing collision tumors consisting of slow-growing and aggressive tumors may prove beneficial in future diagnostic and treatment strategies.

show abstract

Collision Tumor of the Ovary Involving Sertoli-Leydig Cell Tumor and High-Grade Serous Carcinoma—Report of the First Case

Cited by 3 publications

References 26 publications

Ultrasound examination assisted clinical diagnosis of Leydig cell tumor of ovary: An extremely rare case report

Ultrasound examination assisted clinical diagnosis of Leydig cell tumor of ovary: An extremely rare case report

Cylinders and Assemblage- Sertoli-Leydig Cell Tumour -Ovary

Collision Tumor of the Ovary: Adult Granulosa Cell Tumor and Mesonephric-like Adenocarcinoma

Contact Info

Product

Resources

About