Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations

Djurić, Zora; Bassis, Christine M.; Plegue, Melissa; Ren, Jianwei; Chan, Rena; Sidahmed, El Khansa; Turgeon, D. Kim; Kato, Ikuko; Sen, Ananda

doi:10.1016/j.jand.2017.09.013

Cited by 30 publications

(29 citation statements)

References 75 publications

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“…Additionally, an increased abundance of Prevotella sp . was observed in the highest carotenoid tertile [100]. These findings are consistent with other “short-term” dietary intervention studies on the microbiome and suggest that long-term dietary patterns may have a greater impact on changes in microbial ecology.…”

Section: Microbiome and The Mediterranean Diet—the Present Statussupporting

confidence: 89%

Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet

et al. 2019

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The approach to studying diet–health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric microbial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome.

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Section: Microbiome and The Mediterranean Diet—the Present Statussupporting

confidence: 89%

Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet

et al. 2019

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“…Choline and carnitine intake were negatively associated with legume intake at baseline (Table 4). The Mediterranean and Healthy Eating dietary interventions both largely focused on dietary fat and fruit/vegetables and did not appreciably affect the microbiota 33 . Examination of how fiber and legumes influence the TMAO biosynthetic pathway could be topic of future studies.…”

Section: Discussionmentioning

confidence: 99%

“…Bacteria adhering to the biopsies were identified by isolating DNA and sequencing the V4 region of the bacterial-specific 16S rRNA gene as described previously [31][32][33] . Sequencing was done on the Illumina MiSeq platform (San Diego, CA).…”

Section: Colonic Microbiota Analysesmentioning

confidence: 99%

“…The community distance index (θ YC ) was calculated using the method of Yue and Clayton that accounts for proportions of both shared and non-shared species, producing a "Nonparametric Maximum Likelihood Estimator" index, with values between 0 and 1 indicating increasing community diversity 37 . The mean inter-individual θ YC was calculated for samples both at baseline and 6 months after averaging θ YC for all pairs of values at each time point for each sample 33 .…”

Section: Colonic Microbiota Analysesmentioning

confidence: 99%

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A Mediterranean diet does not alter plasma trimethylamineN-oxide concentrations in healthy adults at risk for colon cancer

et al. 2019

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“…However, the gut microbiome has been identified as an important factor in the bioavailability and metabolism of antioxidants (123)(124)(125) and may be involved in caffeine metabolism via mechanisms such as modulation of the expression of the N-acetyltransferase 2 (NAT2) gene (126). Variability in the gut microbiome has been linked to variability in serum carotenoid concentrations (127), which suggests that the gut microbiome does indeed play a role in modulating antioxidant metabolism. In short, the gut microbiome may affect the metabolism of dietary components, supplements, and dietary patterns marketed to and used by athletes, but this is an area of research that has not yet been adequately explored.…”

Section: Personalized Sports Nutrition and The Potential Effect Of Thmentioning

confidence: 99%

A Review of the Role of the Gut Microbiome in Personalized Sports Nutrition

Hughes

2020

Front. Nutr.

103

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The gut microbiome is a key factor in determining inter-individual variability in response to diet. Thus, far, research in this area has focused on metabolic health outcomes such as obesity and type 2 diabetes. However, understanding the role of the gut microbiome in determining response to diet may also lead to improved personalization of sports nutrition for athletic performance. The gut microbiome has been shown to modify the effect of both diet and exercise, making it relevant to the athlete's pursuit of optimal performance. This area of research can benefit from recent developments in the general field of personalized nutrition and has the potential to expand our knowledge of the nexus between the gut microbiome, lifestyle, and individual physiology.

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Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations

Abstract: The colonic mucosal bacterial community was associated with serum carotenoid concentrations at baseline but was not appreciably changed by dietary intervention.

Cited by 30 publications

References 75 publications

Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet

Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet

A Mediterranean diet does not alter plasma trimethylamineN-oxide concentrations in healthy adults at risk for colon cancer

A Review of the Role of the Gut Microbiome in Personalized Sports Nutrition

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