Color Doppler imaging in optic neuritis with multiple sclerosis

Abstract

This study suggests that optic neuritis with multiple sclerosis is associated with impaired retrobulbar hemodynamics, especially in the posterior ciliary and central retinal arteries when compared with the contralateral unaffected eyes as well as healthy control eyes.

Evaluation of Choroidal Vascular Changes in Patients with Multiple Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography

“…Pache et al [4] demonstrated a significant reduction in peak systolic and end-diastolic velocities of the ophthalmic, posterior ciliary and central retinal arteries in MS patients. Akarsu et al [3] reported that MS patients with an ON history had higher resistivity indices in the posterior ciliary and central retinal arteries when compared with healthy controls. Modrzejewska et al [6] showed blood flow velocity disturbances in the short posterior ciliary and central retinal arteries of MS patients.…”

“…Endothelin-1 (ET-1) is one of these molecules and has been found to be increased in MS patients [4,5]. Based on the fact that ET-1 is a potent vasoconstrictor, it has been hypothesized that increased plasma levels of ET-1 might be responsible for the reduction in ocular blood flow of MS patients [3,4]. ET-1 constricts vessels not only via a direct route, but also by increasing the sensitivity of blood vessels to other circulating vasoconstrictors such as norepinephrine and angiotensin-II [4,10].…”

“…Additionally, a possible involvement of vascular factors has been suggested to cause vascular dysregulation in MS patients during the course of the disease [3,4,5]. Taking this fact into account, the possible alterations in the hemodynamics of the orbital vessels in MS patients have been of particular interest and were evaluated in several studies by measuring blood flow velocities with color Doppler imaging.…”

“…Taking this fact into account, the possible alterations in the hemodynamics of the orbital vessels in MS patients have been of particular interest and were evaluated in several studies by measuring blood flow velocities with color Doppler imaging. These studies demonstrated a significant reduction in blood flow parameters and impaired retrobulbar hemodynamics, especially in the posterior ciliary arteries of MS patients [3,4,6]. …”

Multiple sclerosis and optic nerve: an analysis of retinal nerve fiber layer thickness and color Doppler imaging parameters

“…In some studies orbital blood flow velocities were decreased, whereas in others they remained unchanged or even increased. [8][9][10][11][12] Given the conflicting results in previous studies, in the present study, we aimed to investigate the orbital blood flow velocities and RNFL thickness parameters in MS patients, with and without previous ON, and in healthy volunteers.…”