Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester

Jäger, Eliézer; Jäger, Alessandro; Chytil, Petr; Etrych, Tomáš; Řı́hová, Blanka; Giacomelli, Fernando C.; Štěpánek, Petr; Ulbrich, Karel

doi:10.1016/j.jconrel.2012.11.009

Cited by 58 publications

(65 citation statements)

References 47 publications

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“…Cholesterol is a non-toxic lipid, found naturally in humans [26]. In addition, it is widely employed as a hydrophobic anchor for polymeric nanoparticles and liposomes because of its unique properties [17,18,27]. Moreover, cholesterol has cyclic rings in its molecule, which may enhance the interaction between PTX and Chol-BSA because of their similar structure.…”

Section: Discussionmentioning

confidence: 99%

Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug

Battogtokh

Kang

2015

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Discussionmentioning

confidence: 99%

Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug

Battogtokh

Kang

2015

European Journal of Pharmaceutics and Biopharmaceutics

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“…Furthermore, a folate ligand was utilized to allow targeting of the folate receptor and enhance cellular uptake. Other examples include the encapsulation of DTX in a DOX-based HPMA copolymer by Jager et al 102 and the loading of PTX into a floxuiridine-based PVA polymer by Senanayake et al 103 This encapsulation strategy has also been adopted for mono-drug therapies to increase the overall drug content of the PDC, 30, 57, 58, 104, 105 whereby the free form of the conjugated drug is loaded within the PDC micelle during nanostructure formation.…”

Section: Macromolecular Sapdsmentioning

confidence: 99%

Self-assembling prodrugs

et al. 2017

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Covalent modification of therapeutic compounds is a clinically proven strategy to devise prodrugs with enhanced treatment efficacies. This prodrug strategy relies on modified drugs that possess advantageous pharmacokinetic properties and administration routes over their parent drug. Self-assembling prodrugs represent an emerging class of therapeutic agents capable of spontaneously associating into well-defined supramolecular nanostructures in aqueous solutions. The self-assembly of prodrugs expands the functional space of conventional prodrug design, providing a possible pathway to more effective therapies as the assembled nanostructure possesses distinct physicochemical properties that can be tailored to specific administration routes and disease treatment. In this review, we will discuss the various types of self-assembling prodrugs in development, providing an overview of the methods used to control their structure and function and, ultimately, our perspective on their current and future potential.

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“…Jäger and co-workers developed a novel co-delivery system based on core/shell-structured polymeric nanoparticles for cancer therapy. [48] The hydrophobic cores of the nanoparticles were formed from poly(butylene succinateco-butylene dilinoleate) and loaded with hydrophobic docetaxel, while the shells of the nanoparticles were formed from an N-(2-hydroxypropyl) methacrylamide-based copolymer and chemically conjugated with DOX·HCl through hydrazone bonds. Different from micelles, these polymeric nanoparticles exhibited no critical aggregation concentration, which ensured stability of the nanoparticles in bloodstreams.…”

Section: Co-delivery Of Chemical Drugs Using Other Polymeric Nanopartmentioning

confidence: 99%

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

Thambi

Lee

2017

Adv Healthcare Materials

107

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Drug and gene delivery systems based on nanoparticles, microparticles and hydrogels have been widely studied for cancer treatment in the past decade. To achieve an efficient and safe delivery, selection of drug and gene delivery carrier is critical. Biocompatible polymeric nanoparticles are considerably promising carrier candidates in delivery of drugs and genes because of their unique chemical and physical properties. However, delivery of a drug or gene sometimes cannot achieve a satisfactory treatment effect. Therefore, co‐delivery of dual drugs or co‐delivery of a drug and a gene in a polymeric nanoparticle has attracted attention. Such co‐delivery systems can overcome multi‐drug resistance of chemical drugs and achieve a synergistic therapeutic effect. In this progress report, we summarize recent progress in the preparation and application of polymeric drug and gene co‐delivery nanosystems. The remaining challenges and future trends in this field are also included.

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Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester

Cited by 58 publications

References 47 publications

Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug

Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug

Self-assembling prodrugs

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

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