Combination dopamine agonist and prostaglandin agonist treatment of cystic endometrial hyperplasia–pyometra complex in the bitch

Corrada, Yanina Alejandra; Arias, Daniel Osvaldo; Rodríguez, Raúl Ricardo; Tortora, M; Gobello, Cristina

doi:10.1016/j.theriogenology.2006.01.004

Cited by 27 publications

(22 citation statements)

References 2 publications

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“…As reported by Onclin et al (1993) prolactin is the most important hormone regulating the corpora lutea of bitches and due to its luteotrophic property, repeated administration of prolactin inhibitors at a time more than 25 days after ovulation can result in a rapid and permanent reduction in plasma progesterone concentrations by causing substantial luteolysis in bitches. Clinical recovery after treatment of the bitches using a combination of cloprostenol and cabergoline might be due to synergistic effects of dopaminergic agonists and PGF 2 α which potentiated the action of PGF 2 α resulting in the induction of rapid luteolysis as reported by Corrada et al (2006) and Verstegen et al (2008). England et al (2007) reported that the combination of a prolactin inhibitor and prostaglandin appeared to be effective in rapidly terminating the luteal phase and promoting uterine evacuation.…”

Section: Discussionmentioning

confidence: 93%

“…England et al (2003) successfully treated bitches affected with pyometra using the combination of cloprostenol and cabergoline. Corrada et al (2006) reported 83% recovery rate using a combination of cloprostenol and cabergoline for the treatment of pyometra. England et al (2007) reported a normal blood haematological profile and normal serum biochemistry in all the treated bitches affected with pyometra after completion of treatment using a combination of cabergoline and cloprostenol.…”

Section: Discussionmentioning

confidence: 99%

“…The combination of these drugs thus permitted the use of lower PGF 2 α doses, which reduced the side effects. Additionally, PGF 2 α caused uterine contractions and promoted uterine evacuation contributing to treatment of the condition (England et al 2003;Corrada et al 2006).…”

Section: Discussionmentioning

confidence: 99%

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Comparative efficacy of various therapeutic protocols in the treatment of pyometra in bitches

Jena¹,

Rao²,

Reddy³

et al. 2013

Vet. Med. - Czech

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This study was undertaken on canine pyometra and consisted of 28 bitches of different breeds with known breeding history and open type of pyometra. The diagnosis of pyometra was made by correlating the history and clinical signs with the findings of abdominal palpation, radiography and ultrasonography. The physiological, haematological and biochemical parameters were evaluated before and at the end of therapy. The clinical cases were divided randomly into four different groups with each group consisting of seven bitches. One untreated control group in which bitches were given only supportive therapies was included. The bitches in the other three groups were treated using natural PGF 2 α or synthetic PGF 2 α or a combination of a dopamine agonist prolactininhibiting drug, i.e., cabergoline and lower dose of synthetic PGF 2 α (Cloprostenol) along with supportive therapies. Treatment of canine pyometra by the use of different drugs was found to be successful. Though a lower dose of cloprostenol was effective in treating pyometra, it is not recommended due to high rates of recurrence and lower conception rates. Treatment of canine pyometra using a combination of a dopamine agonist prolactin-inhibiting drug (Cabergoline) and a lower dose of synthetic PGF 2 α (Cloprostenol) was found to be the most effective method among the three therapeutic protocols used in the present study.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Comparative efficacy of various therapeutic protocols in the treatment of pyometra in bitches

Jena¹,

Rao²,

Reddy³

et al. 2013

Vet. Med. - Czech

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“…To maintain fertility or if surgery or anesthesia is to be avoided, several medical treatment alternatives are available. Examples of drugs that can be used for medical treatment of pyometra include progesterone-receptor antagonists (aglepristone and mifepristone), prostaglandins (dinoprost and cloprostenol), dopamine agonists (cabergoline), or different combinations of these drugs [11][12][13][14][15]. Few studies have evaluated the long-term outcome after medical treatment, and for aglepristone, the time of follow-up evaluation varies from after the following estrus [16,17], after 1 year [18], after 2 years [19], or up to 54 months after treatment for a few bitches [13].…”

Section: Introductionmentioning

confidence: 99%

A retrospective study of bitches with pyometra, medically treated with aglepristone

2014

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Pyometra is a common and life-threatening disease of intact bitches caused by hormonal influence of the uterus in combination with bacterial infection. The treatment of choice is ovariohysterectomy, but several purely medical options are available. Common drugs used for medical treatment in combination with antimicrobials are progesterone receptor blockers, prostaglandins, and dopamine agonists. The aim of this study was to evaluate long-term recovery and fertility after treatment with the progesterone receptor blocker aglepristone in bitches with pyometra. Data from 28 bitches with pyometra, admitted to the University Animal Hospital, Swedish University of Agricultural Sciences, during a 9-year period, were studied retrospectively and followed up by telephone interviews with the owners. The bitches had been treated with aglepristone at a dose of 10 mg/kg on a median of four occasions. All bitches had also been treated with antimicrobial drugs for a mean duration of 23 days, the most frequently used being enrofloxacin. Escherichia coli were the most commonly isolated bacteria from cranial vagina. The outcome was assessed for up to 6 years after treatment. The success rate, determined as restored clinically healthy status, was 75% (21/28 bitches), and the recurrence rate of disease was 48% (10/21 bitches). The mean time until recurrence was 10.5 months after the end of treatment. After treatment, 69% (9/13) of the mated bitches produced puppies. Of the seven bitches that did not have a successful treatment, six were ovariohysterectomized and one was euthanized. In conclusion, medical treatment with aglepristone in combination with antimicrobial therapy was successful in 75% of the bitches studied and the recurrence rate was 48%.

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“…It also causes luteolysis, which decreases progesterone concentrations. Fewer side effects can be achieved by using protocols with lower and more frequent prostaglandin doses, 29 intravaginal administration of prostaglandin, 30 combining prostaglandin with other agents such as antiprogestins 26 or dopamine agonists, 28 administering prostaglandin 1 to 2 hours from feeding, and walking the patient immediately afterward for 20 to 40 minutes. Additional side effects of PGF 2α treatment in queens that were not observed in dogs included vocalization, grooming, kneading, mydriasis, and lordosis.…”

Section: Medical Managementmentioning

confidence: 99%

Pyometra

Crane¹

2015

Small Animal Critical Care Medicine

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Combination dopamine agonist and prostaglandin agonist treatment of cystic endometrial hyperplasia–pyometra complex in the bitch

Cited by 27 publications

References 2 publications

Comparative efficacy of various therapeutic protocols in the treatment of pyometra in bitches

Comparative efficacy of various therapeutic protocols in the treatment of pyometra in bitches

A retrospective study of bitches with pyometra, medically treated with aglepristone

Pyometra

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