Combination of Sonographic Morphology Score and Tumor Markers for Detecting Postoperative Recurrent Pelvic Ovarian Carcinoma

Shen, Zhi Yong; Shen, Ai Jun; Yang, Shao Ling; Wu, Ming

doi:10.1097/ruq.0000000000000394

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…The advantage of using the US in the follow-up of gynecological cancers has been demonstrated since 1987 [24][25][26][27]. Testa et al [27] stated that the positive predictive value of the US examination in detecting the recurrence of gynecological malignancies was 100%, while the negative one was 92.7%.…”

Section: Tcbn In Recurrent Cancermentioning

confidence: 99%

Ultrasound-Guided Tru-Cut Biopsy in Gynecological and Non-Gynecological Pelvic Masses: A Single-Center Experience

Buonomo

Bussolaro

Fiorillo

et al. 2022

JCM

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Aim: The aim of this study was to evaluate the feasibility of adequacy, accuracy, and safety of ultrasound-guided tru-cut biopsy in managing malignant and benign abdominopelvic masses in a selected population and critically discuss some issues in different situations, which deserve some reflections on those practices. Materials and Methods: This is a retrospective study involving 42 patients who underwent transvaginal or transabdominal tru-cut biopsy between August 2017 and November 2021. The inclusion criteria were poor health status or primary inoperable advanced tumor, suspicion of recurrence or metastasis to the ovaries or peritoneum in gynecological and non-gynecological pelvic malignancies. Tissue samples were considered adequate if it was possible to determine the origin of the tumor, and immunohistochemistry could be performed. Diagnostic accuracy was assessed considering the agreement between tru-cut biopsy histology and final postoperative histology. Results: It total, 44 biopsies were obtained from 42 patients (2 patients had repeat biopsies). The pathologist considered all pathological samples adequate (adequacy 100%). The final histology was consistent with tru-cut biopsy diagnosis in all but 2 cases (diagnostic accuracy 88.2%). If we consider only the cases that have carried out at least two diagnostic samples, accuracy rose to 94.1%. Pathological examinations from tru-cut samples showed 2 benign lesions (4.8%) and 40 malignant tumors (95.2%), divided into 19 advanced primary inoperable ovarian cancers, 7 primary advanced cervical cancers, 4 recurrent endometrial cancers, 3 recurrent cervical cancers, 3 recurrent ovarian cancers, 1 case of primitive peritoneal malignancy (leiomyosarcoma), and 3 non-gynecological cancers with a strong suspicion of metastases at ultrasound (2 cases of ovarian, colorectal cancer metastasis, and 1 case of pelvic site type B lymphoma metastasis). However, one case of minor complication related to the procedure was reported but not significant. Conclusions: The diagnostic adequacy, accuracy of the tru-cut biopsy, and safety were high. Pathological samples are representative of the disease and suitable for histological and immunohistochemical analysis.

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Section: Tcbn In Recurrent Cancermentioning

confidence: 99%

Ultrasound-Guided Tru-Cut Biopsy in Gynecological and Non-Gynecological Pelvic Masses: A Single-Center Experience

Buonomo

Bussolaro

Fiorillo

et al. 2022

JCM

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show abstract

“…Trans-vaginal (TV) and trans-rectal (TR) US probes allow a detailed visualization of the pelvic structures, while trans-abdominal (TA) probes rely on lower frequency probes and the image resolution mostly depends on the dimensions of the lesions and the patient's habitus. OC recurrences are mainly described in US as hypoechoic single solid lesions with irregular margins, a moderate to rich vascularization at color Doppler (CD) and are usually associated with ascites or pelvic free-fluid (34)(35)(36).…”

Section: The Role Of Us In the Detection Of Recurrent Disease After D...mentioning

confidence: 99%

“…Secondary lesions are usually smaller than the primary tumor, with an average size of 2 to 4 cm whereas the primary tumor is typically larger (8-12 cm for serous OC, 18 to 20 cm for mucinous cancer) (34,36).…”

Section: The Role Of Us In the Detection Of Recurrent Disease After D...mentioning

confidence: 99%

“…More recently, an effort has been led from Shen et al in 2019 (36) to overcome the limit of US in the detection of such extra-pelvic or diffuse peritoneal recurrences. They suggested a combination of US features with the rising curve of CA-125 and HE4 in order to potentially detect these recurrences typically misdiagnosed at US.…”

Section: The Role Of Us In the Detection Of Recurrent Disease After D...mentioning

confidence: 99%

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Role of ultrasound in the detection of recurrent ovarian cancer: a review of the literature

et al. 2020

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BackgroundOvarian cancer (OC) is the leading cause of death among gynecological cancers, and the fifth leading cause of death in women among all cancers (1). Despite improvements in technology and the accuracy of radiological and laboratory diagnostic tests, around 60% of OC is actually diagnosed at an advanced stage, which therefore remains the main prognostic factor (1).The complete surgical removal of the disease, followed by platinum based chemotherapy, has still the greatest impact on survival for advanced OC (2,3), while a fertility sparing surgery (FSS) appears to be safe just in patients with low-grade stage IA (serous, endometrioid or mucinous expansile subtype) (4,5), and acceptable for stage IC1 tumors, where about 50% of recurrences are located in the remaining ovary and therefore suitable for subsequent surgery (6).

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“…However, two-dimensional transvaginal ultrasound can only provide information about the large vessels of the tumor and macroscopically evaluate the blood supply and distribution inside the lesion, with poor exploration and display results for some microcirculation and small vessels. There are significant differences between the neovascular structure of tumor tissue and normal blood vessel in many aspects such as vessel diameter, basilar membrane walking, vessel diameter, and vascular network morphology ( 5 , 6 ). With the development of contrast-enhanced ultrasound and related imaging techniques, it is possible to study diseases from the perfusion level of tissue microcirculation, which greatly improves the accuracy of ultrasound diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Two-Dimensional Transvaginal Ultrasound Combined with Contrast-Enhanced Ultrasound in Ovarian Cancer

Shahai

Liu

et al. 2022

Front. Surg.

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ObjectiveExplore the value of two-dimensional transvaginal ultrasound combined with contrast-enhanced ultrasound in the differential diagnosis of ovarian cancer, so as to provide the basis for clinical diagnosis and treatment of ovarian cancer.MethodsA total of 100 suspected ovarian cancer patients who were admitted to our hospital from January 2019 to December 2021 were selected as the research subjects, including 62 ovarian cancer patients (ovarian cancer group) and 38 ovarian benign tumor patients (benign group). Two-dimensional vaginal ultrasound and contrast-enhanced ultrasound were performed in both groups. The differences in PI, RI, EDV, PSV, and VM parameters of the two groups as well as those of patients with ovarian cancer of different grades were compared. Record the contrast-enhanced ultrasound parameters such as AT, TTP and IMAX, and determine the diagnostic value.ResultsThe PI and RI of the ovarian cancer group were lower than those of the benign ovarian tumor group, and the EDV, PSV and VM of the ovarian cancer group were higher than those of the benign ovarian tumor group (p < 0.05). The PI and RI of the patients in stage I–II of the ovarian cancer group were higher than those in stage III–IV, and the EDV, PSV and VM were lower than those in the patients in stage III–IV, with statistical significance (p < 0.05). The results of contrast-enhanced ultrasound showed that the AT and TTP values in the ovarian cancer group were significantly shorter than those in the benign group, and the peak intensity was significantly higher than that in the benign group, and the differences were statistically significant (p < 0.05). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of two-dimensional ultrasound combined with contrast-enhanced ultrasound in the diagnosis of ovarian cancer were high, 95.16%(59/62), 86.84%(33/38), 92.19%(59/64), 91.67%(33/36) and 92.00%(92/100), respectively.ConclusionContrast-enhanced ultrasound to some extent makes up for the deficiencies of conventional ultrasound, is helpful to detect early ovarian cancer, and can be used for the differential diagnosis of small ovarian tumors with difficult two-dimensional ultrasound diagnosis. Two-dimensional ultrasound combined with contrast-enhanced ultrasound can effectively improve the detection rate and differential diagnosis value of ovarian cancer, which is of great significance in the early diagnosis and differentiation of ovarian cancer.

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Combination of Sonographic Morphology Score and Tumor Markers for Detecting Postoperative Recurrent Pelvic Ovarian Carcinoma

Cited by 4 publications

References 22 publications

Ultrasound-Guided Tru-Cut Biopsy in Gynecological and Non-Gynecological Pelvic Masses: A Single-Center Experience

Ultrasound-Guided Tru-Cut Biopsy in Gynecological and Non-Gynecological Pelvic Masses: A Single-Center Experience

Role of ultrasound in the detection of recurrent ovarian cancer: a review of the literature

Diagnostic Value of Two-Dimensional Transvaginal Ultrasound Combined with Contrast-Enhanced Ultrasound in Ovarian Cancer

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