Combinatorial microfluidic droplet engineering for biomimetic material synthesis

Bawazer, Lukmaan A.; McNally, Ciara S.; Empson, Christopher J.; Marchant, William J.; Comyn, Tim P.; Niu, Xize; Cho, Soongwon; McPherson, Michael J.; Binks, Bernard P.; deMello, Andrew J.; Meldrum, Fiona C.

doi:10.1126/sciadv.1600567

Cited by 76 publications

(54 citation statements)

References 63 publications

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“…They are multifunctional units that can perform locomotion, sensing, capture, and release . Further, combinatorial microfluidics is used to create a droplet generation platform with enhanced stability to synthesize biomimetic materials for various applications …”

Section: Introductionmentioning

confidence: 99%

PDMS microfluidics: A mini review

Chakraborty

2020

J of Applied Polymer Sci

324

167

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Polydimethylsiloxane (PDMS) is hailed as one of the foundational materials for microfluidics. Though a silicone‐based elastomer of many desirable properties, the emergence of microfluidic fabrication techniques, especially soft lithography, has elevated its status to an exceptional one. In this mini review, we look at the salient aspects that make PDMS so special in achieving such a coveted status in the microfluidics community. A methodical approach is followed to touch upon the application of PDMS in various aspects of microfluidics with the advantages, limitations, and some future directions. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48958.

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Section: Introductionmentioning

confidence: 99%

PDMS microfluidics: A mini review

Chakraborty

2020

J of Applied Polymer Sci

324

167

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“…These reactions are catalyzed extremely efficiently to produce various special substances; therefore, the investigation of cells is highly significant for multidiscipline. In recent years, the fabrication of artificial biomimetic materials has attracted a great deal of attention . Attributed for the development of materials science and engineering science, various artificial organs, such as heart, blood vessels, liver acinus, skin, muscle, and nerve, have been fabricated.…”

Section: Introductionmentioning

confidence: 99%

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

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Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the subcategories of biomimetic materials, artificial cells are highly significant for multiple disciplines and their synthesis has been intensively pursued. In order to manufacture robust “alive” artificial cells with high throughput, easy operation, and precise control, flexible microfluidic techniques are widely utilized. Herein, recent advances in microfluidic‐based methods for the synthesis of droplets, vesicles, and artificial cells are summarized. First, the advances of droplet fabrication and manipulation on the T‐junction, flow‐focusing, and coflowing microfluidic devices are discussed. Then, the formation of unicompartmental and multicompartmental vesicles based on microfluidics are summarized. Furthermore, the engineering of droplet‐based and vesicle‐based artificial cells by microfluidics is also reviewed. Moreover, the artificial cells applied for imitating cell behavior and acting as bioreactors for synthetic biology are highlighted. Finally, the current challenges and future trends in microfluidic‐based artificial cells are discussed. This review should be helpful for researchers in the fields of microfluidics, biomaterial fabrication, and synthetic biology.

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“…Up to now, a number of reviews about microfluidic fabrication of materials have been reported from different aspects, which mainly refer to certain microfluidic technologies (e.g., droplet microfluidics) or specific forms of materials (e.g., microparticles) . However, a comprehensive review that puts the attention on microfluidic fabrication of NMs and their biomedical applications is unavailable.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Generation of Nanomaterials for Biomedical Applications

Zhao

Bian

Sun

et al. 2019

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As nanomaterials (NMs) possess attractive physicochemical properties that are strongly related to their specific sizes and morphologies, they are becoming one of the most desirable components in the fields of drug delivery, biosensing, bioimaging, and tissue engineering. By choosing an appropriate methodology that allows for accurate control over the reaction conditions, not only can NMs with high quality and rapid production rate be generated, but also designing composite and efficient products for therapy and diagnosis in nanomedicine can be realized. Recent evidence implies that microfluidic technology offers a promising platform for the synthesis of NMs by easy manipulation of fluids in microscale channels. In this Review, a comprehensive set of developments in the field of microfluidics for generating two main classes of NMs, including nanoparticles and nanofibers, and their various potentials in biomedical applications are summarized. Furthermore, the major challenges in this area and opinions on its future developments are proposed.

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Combinatorial microfluidic droplet engineering for biomimetic material synthesis

Abstract: Combinatorial chemical evolution is used to select oil-water droplet interfaces that drive inorganic nanoparticle synthesis.

Cited by 76 publications

References 63 publications

PDMS microfluidics: A mini review

PDMS microfluidics: A mini review

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Microfluidic Generation of Nanomaterials for Biomedical Applications

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