Combined antibacterial/tissue regeneration response in thermal burns promoted by functional chitosan/silver nanocomposites

Luna-Hernández, E.; Cruz, M.; Padilla‐Vaca, Felipe; Mauricio-Sánchez, Reina Araceli; Wong, Diana Guadalupe Ramirez; Vázquez-Muñoz, Roberto; Granados-López, L.; Ovalle-Flores, L.R.; Menchaca-Arredondo, Jorge Luis; Hernández-Rangel, Adriana; Prokhorov, E.; García-Rivas, José Luis; España‐Sánchez, Beatriz Liliana; Luna‐Bárcenas, Gabriel

doi:10.1016/j.ijbiomac.2017.07.159

Cited by 39 publications

(15 citation statements)

References 45 publications

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“…92 It is a highly biocompatible biodegradable material and shows antibacterial properties against pathogenic bacteria, with potential application as an antimicrobial agent. 93 These properties make CS suitable for surface modification of AgNPs. The hydrogels based on CS and modified with AgNPs exhibit toxicity in relation to S. aureus and did not exert any negative impact on the cells of the dermis.…”

Section: Combination With Biomoleculesmentioning

confidence: 99%

“…From the results, the CS/nAg nanocomposites showed enhanced antibacterial and biocompatibility properties. 93 Low-molecular-weight CS (LMWC) has better water solubility and biological activity than higher degree of polymerization of CS. Compared with AgNPs coated with high-molecular-weight CS, AgNPs coated with LMWC were more effective against methicillin-resistant S. aureus and showed better biocompatibility and lower body absorption characteristics.…”

Section: Combination With Biomoleculesmentioning

confidence: 99%

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Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Qing

Cheng

et al. 2018

IJN

764

362

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Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.

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Section: Combination With Biomoleculesmentioning

confidence: 99%

Section: Combination With Biomoleculesmentioning

confidence: 99%

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Qing

Cheng

et al. 2018

IJN

764

362

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“…Chitosan (CS) is a biocompatible and biodegradable natural polymer, commonly used in the biomedical field [30][31][32][33]. By incorporating AgNPs into CS, one can obtain anti-microbial nanocomposites that can be used for a wide range of applications such as wound dressings, tissue engineering, drug delivery and water treatment, etc [34][35][36]. In the present work, a direct current (DC) atmospheric pressure microplasma has been deployed for the in situ synthesis of AgNP/CS nanocomposites.…”

Section: Oh• H• and O•)mentioning

confidence: 99%

Atmospheric pressure microplasma for antibacterial silver nanoparticle/chitosan nanocomposites with tailored properties

Sun

Turner

Jiang

et al. 2020

Composites Science and Technology

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Room temperature atmospheric pressure microplasma (APM) was deployed for the first time for the in situ synthesis of anti-bacterial silver nanoparticle/chitosan (AgNP/CS) nanocomposites. The plasma induced liquid chemistry plays a role in the in situ formation of AgNP, the size distribution of which depends on the silver salt precursor concentration. The microplasma process has also simultaneously tailored the physical properties of the composites, through molecular chain scission and formation of physically crosslinked polymer network. The formation of AgNP within the in situ modified chitosan has led to nanocomposites with overall improved mechanical properties and better stability in simulated body fluid. Our plasma synthesized AgNP/CS nanocomposites also demonstrate effective antibacterial properties against E. coli and S. aureus bacterial strains, showing their promise in potential antimicrobial applications.

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“…The material with the highest chitosan-silver nanoparticle content was tested against E. coli and showed significant antibacterial activity. A combined antibacterial/tissue regeneration response triggered by functional chitosan-silver nanocomposites was also reported for thermal burns (Luna-Hernandez et al 2017). To increase antibacterial activity wound dressings, several groups combined chitosan-silver-based materials with sulfadiazine, a sulfonamide antibiotic.…”

Section: Cutaneous Wound Healingmentioning

confidence: 92%

Chitin/Chitosan: Versatile Ecological, Industrial, and Biomedical Applications

Merzendorfer

Cohen

2019

Biologically-Inspired Systems

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Chitin is a linear polysaccharide of N-acetylglucosamine, which is highly abundant in nature and mainly produced by marine crustaceans. Chitosan is obtained by hydrolytic deacetylation. Both polysaccharides are renewable resources, simply and cost-effectively extracted from waste material of fish industry, mainly crab and shrimp shells. Research over the past five decades has revealed that chitosan, in particular, possesses unique and useful characteristics such as chemical versatility, polyelectrolyte properties, gel-and film-forming ability, high adsorption capacity, antimicrobial and antioxidative properties, low toxicity, and biocompatibility and biodegradability features. A plethora of chemical chitosan derivatives have been synthesized yielding improved materials with suggested or effective applications in water treatment, biosensor engineering, agriculture, food processing and storage, textile additives, cosmetics fabrication, and in veterinary and human medicine. The number of studies in this research field has exploded particularly during the last two decades. Here, we review recent advances in utilizing chitosan and chitosan derivatives in different technical, agricultural, and biomedical fields.

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Combined antibacterial/tissue regeneration response in thermal burns promoted by functional chitosan/silver nanocomposites

Cited by 39 publications

References 45 publications

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Atmospheric pressure microplasma for antibacterial silver nanoparticle/chitosan nanocomposites with tailored properties

Chitin/Chitosan: Versatile Ecological, Industrial, and Biomedical Applications

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