Combined effect of diet and cervical microbiome on the risk of cervical intraepithelial neoplasia

Seo, Sang Soo; Oh, Hyun-Joo; Lee, Jae Kwan; Kong, Jeong-Taek; Lee, Dong Ock; Kim, Mi Kyung

doi:10.1016/j.clnu.2016.03.019

Cited by 63 publications

(79 citation statements)

References 35 publications

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“…Our systematic search resulted in 11 eligible included articles (Figure ), of which the general characteristics and quality assessment are described in the Supplementary material (Tables S2 and S3). Reasons for exclusion of the articles excluded after full text screening are reported in the Supplementary material (Appendix S2), with 15 studies lacking essential data for inclusion in the network meta‐analysis …”

Section: Resultsmentioning

confidence: 99%

The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta‐analysis

Norenhag

Olovsson

et al. 2019

BJOG

258

219

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Background Persistent infection with high-risk human papillomavirus can lead to cervical dysplasia and cancer. Recent studies have suggested associations between the composition of the vaginal microbiota, infection with human papillomavirus (HPV) and progression to cervical dysplasia and cancer.Objective To assess how specific cervico-vaginal microbiota compositions are associated with HPV infection, cervical dysplasia and cancer, we conducted a systematic review and network metaanalysis (registered in PROSPERO: CRD42018112862).Search strategy PubMed, Web of science, Embase and Cochrane database.Selection criteria All original studies describing at least two community state types of bacteria (CST), based on molecular techniques enabling identification of bacteria, and reporting the association with HPV infection, cervical dysplasia and/or cervical cancer.Data collection and analysis For the meta-analysis, a network map was constructed to provide an overview of the network relationships and to assess how many studies provided direct evidence for the different vaginal microbiota compositions and HPV, cervical dysplasia or cancer. Thereafter, the consistency of the model was assessed, and forest plots were constructed to pool and summarise the available evidence, presenting odds ratios and 95% confidence intervals.Main results Vaginal microbiota dominated by non-Lactobacilli species or Lactobacillus iners were associated with three to five times higher odds of any prevalent HPV and two to three times higher for high-risk HPV and dysplasia/cervical cancer compared with Lactobacillus crispatus.Conclusions These findings suggest an association between certain bacterial community types of the vaginal microbiota and HPV infection and HPV-related disease. This may be useful for guiding treatment options or serve as biomarkers for HPV-related disease.Tweetable abstract This network meta-analysis suggests an association between different vaginal bacterial community types and the risk of HPV.

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Section: Resultsmentioning

confidence: 99%

The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta‐analysis

Norenhag

Olovsson

et al. 2019

BJOG

258

219

View full text Add to dashboard Cite

show abstract

“…A handful of studies have examined the association between the vaginal microbiome and cervical intraepithelial neoplasia (CIN) (see Table ). In general, microbiomes rich in L. crispatus were associated with healthy patients . Lactobacillus iners , on the other hand, was associated with cervical cancer alone or in conjunction with HPV infection, as well as higher grades of CIN in HPV‐positive patients .…”

Section: Influence Of Vaginal Microbiome On Carcinogenesismentioning

confidence: 98%

“…In general, microbiomes rich in L. crispatus were associated with healthy patients . Lactobacillus iners , on the other hand, was associated with cervical cancer alone or in conjunction with HPV infection, as well as higher grades of CIN in HPV‐positive patients . Conversely, another study found that L. iners was associated with reduced risk of squamous intraepithelial lesions and cervical cancer .…”

Section: Influence Of Vaginal Microbiome On Carcinogenesismentioning

confidence: 99%

“…Other species of Lactobacillus were also variably associated with CIN . A diverse array of less abundant bacterial species were associated with CIN, including Atopobium vaginae , G. vaginalis , Fusobacterium and others . Cytokine profiling revealed higher local levels of interleukin (IL)‐4 and transforming growth factor (TGF)‐β1 mRNAs in microbiomes dominated by Fusobacterium .…”

Section: Influence Of Vaginal Microbiome On Carcinogenesismentioning

confidence: 99%

“…Similarly, patients with squamous intraepithelial lesions tended to have microbiomes enriched in Sneathia . Diet could potentially affect the microbiome, and it was found that women with semi‐Western‐style diets as opposed to a diet rich in fish and vegetables had a higher rate of CIN …”

Section: Influence Of Vaginal Microbiome On Carcinogenesismentioning

confidence: 99%

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