Combined I-124 Positron Emission Tomography/Computed Tomography Imaging of NIS Gene Expression in Animal Models of Stably Transfected and Intravenously Transfected Tumor

Dingli, David; Kemp, Brad; O’Connor, Michael K.; Morris, John C.; Russell, Stephen J.; Lowe, Val J.

doi:10.1007/s11307-005-0025-0

Cited by 55 publications

(40 citation statements)

References 28 publications

(20 reference statements)

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“…Potassium perchlorate (KClO 4 ) has been used in rats 6-18 hours following injection of 125 I and shown to reduce the 125 I thyroid/blood ratio when thyroid peroxidase is inhibited (51,52). 124 I positron emission tomography/computerized tomography (PET/CT) has been used rarely to evaluate uptake and discharge of iodide in rodent thyroids in vivo (53).…”

Section: And Recommendation 3amentioning

confidence: 99%

See 1 more Smart Citation

American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

Bianco

Anderson

Forrest

et al. 2014

Thyroid

174

106

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Section: And Recommendation 3amentioning

confidence: 99%

“…The sensitivity of PET is higher than that of a scintillation camera, as well as the contrast and spatial resolution (53). For accurate thyroid imaging in rats, the combination of microPET and micro computed axial tomography with 124 I is necessary (Fig.…”

Section: Commentarymentioning

confidence: 99%

American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

Bianco

Anderson

Forrest

et al. 2014

Thyroid

174

106

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“…PET combined with computerized tomography has a ten times higher resolution than conventional imaging and permits precise anatomical localization. In an attempt to develop this promising approach, two studies have demonstrated that hNIS expression in tumor xenograft models can be monitored by PET after intravenous injection of 124 I, demonstrating the potential of this approach for noninvasive imaging (128,129).…”

Section: Nis Gene Transfermentioning

confidence: 99%

A perspective view of sodium iodide symporter research and its clinical implications

2006

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The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active iodide transport into the thyroid gland and into several extrathyroidal tissues, in particular the lactating mammary gland. Cloning and molecular characterization of the NIS have allowed the investigation of its key role in thyroid physiology as well as its potential pathophysiological and therapeutic implications in benign and malignant thyroid diseases. Similarly, elucidating the mechanisms underlying the regulation of NIS in lactating mammary gland and breast cancer, in which more than 80% of cases express endogenous NIS, may lead to findings that have novel implications for pathophysiology and therapy. Two approaches may, in the future, pave the way to extend the use of radioiodide treatment to nonthyroidal cancer. One is based on the reinduction of endogenous NIS expression in thyroid and breast cancer by targeting the main mechanisms involving tumoral transformation and dedifferentiation. The other is based on the application of NIS as a novel cytoreductive gene therapy strategy. NIS offers the unique advantage that it can be used both as a reporter and as a therapeutic gene, so that it is possible to image, monitor, and treat the tumor with radioiodide, just as in differentiated thyroid cancer. This review summarizes the main recent findings in NIS research that have a direct impact on diagnosis and therapeutic management. European Journal of Endocrinology 155 495-512

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“…Dieses Isotop wird ebenfalls in Radiopharmaka inkorporiert verwendet. [182] Der wesentliche Vorteil ist hierbei seine län-gere Halbwertszeit gegenüber der von 18 F. 135 I ist ein in Kernreaktoren häufig gebildetes Isotop.…”

Section: Angewandte Chemieunclassified

Zweihundert Jahre Iodforschung: ein interdisziplinärer Überblick über die derzeitige Forschung

et al. 2011

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Iod als neues Element wurde im Zusammenhang mit den Napoleonischen Kriegen 1811 entdeckt. Zum Anlass dieses zweihundertjährigen Jubiläums möchten wir auf die Geschichte der Erforschung und Nutzung dieses Elements zurückblicken und die vielen Facetten der Iodforschung beleuchten, die sich seit der Entdeckung herausgebildet haben. Iod beeinflusst viele Aspekte des Lebens auf der Erde und der menschlichen Zivilisation. Es wird in hohen Konzentrationen von marinen Algen akkumuliert, die die Ursache für einen bedeutenden Eintrag von Iod in die Küstenatmosphäre sind und dabei klimatische Prozesse beeinflussen. In marinen Sedimenten wird Iod als biophiles Element angesehen. Iod ist entscheidend für die Schilddrüsenfunktion von Wirbeltieren und damit von großer Bedeutung für die menschliche Gesundheit. Iod kommt in einer großen Zahl von Oxidationszuständen vor und zeichnet sich durch eine vielfältige supramolekulare Chemie aus. Iod ist einer Reihe analytischer Techniken zugänglich, und Iodverbindungen werden vielfach in organischen Synthesen eingesetzt. Elementares Iod wird in industriellen Größenordnungen produziert und findet ein breites Spektrum industrieller Anwendungen, insbesondere bei innovativen Werkstoffen wie Halbleitern – besonders auch in Solarzellen.

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Combined I-124 Positron Emission Tomography/Computed Tomography Imaging of NIS Gene Expression in Animal Models of Stably Transfected and Intravenously Transfected Tumor

Cited by 55 publications

References 28 publications

American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

A perspective view of sodium iodide symporter research and its clinical implications

Zweihundert Jahre Iodforschung: ein interdisziplinärer Überblick über die derzeitige Forschung

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