Within developing countries, there is an appeal to use waste biomass for energy generation in the form of bio-briquettes. This study investigated the potential use of bio-briquettes that are produced from the waste biomass of the following tropical fruits: durian (Durio zibethinus), coconut (Cocos nucifera), coffee (Coffea arabica), cacao (Theobroma cacao), banana (Musa acuminata) and rambutan (Nephelium lappaceum). All fruit waste biomass samples exhibited an extremely high level of initial moisture content (78.22% in average). Fruit samples with the highest proportion of fruit waste biomass (of total unprocessed fruit mass) were represented by cacao (83.82%), durian (62.56%) and coconut (56.83%). Highest energy potentials (calorific value) of fruit waste biomass were observed in case of coconut (18.22 MJ·kg −1 ), banana (17.79 MJ·kg −1 ) and durian (17.60 MJ·kg −1 ) fruit samples, whereas fruit waste biomass with the lowest level of ash content originated from the rambutan (3.67%), coconut (4.52%), and durian (5.05%) fruit samples. When investigating the energy demands to produce bio-briquettes from such feedstock materials, the best results (lowest amount of required deformation energy in combination with highest level of bio-briquette bulk density) were achieved by the rambutan, durian and banana fruit waste biomass samples. Finally, all investigated bio-briquette samples presented satisfactory levels of bulk density (>1050 kg·m −3 ). In conclusion, our results indicated the practicability and viability of such bio-briquette fuel production, as well as supporting the fact that bio-briquettes from tropical fruit waste biomass can offer a potentially attractive energy source with many benefits, especially in rural areas.