Comfort and Infection Control of Chitosan-impregnated Cotton Gauze as Wound Dressing

Abstract

The aim of this study was to evaluate the thermo-physiological comfort properties of surgical cotton gauze coated with chitosan (CH) and its effectiveness for the prevention of bacterial colonization. Gauze was coated with CH at mass fractions of 0.50, 0.25, 0.125, 0.10, 0.063 wt% and the friction, flexibility, thermal, moisture management and mechanical properties were evaluated. The best performing gauze in terms of comfort (0.125 wt%) was further evaluated for its ability to inhibit the growth of microorganisms such as bacteria and yeast. Results indicate that the functionalized medical gauze could induce low friction on the wound bed allowing a good degree of moisture and high absorption capacity of wound exudates. Moreover, it shows antimicrobial properties against medical-relevant pathogens. This biofunctional medical gauze demonstrates to deliver an efficient antimicrobial coating and promote the best conditions for maintenance of the wound microenvironment.

Highly Antibacterial and Adhesive Hyaluronic Acid Hydrogel for Wound Repair

“…Wound dressings including gauze, bandages, and sponges are usually used as a protective barrier for wound healing. − Although these traditional dressings could promote wound healing to some extent, they still face some defects such as poor permeability, weak fluid absorption, and secondary damage caused by wound-to-dressing adhesion. , Therefore, multifunctional dressings are important to be designed and synthesized to meet the needs of various wound healing requirements. In recent years, to promote wound healing, some small-molecule compounds that can produce NO are covalently bonded with polymer materials (poly­(ethylene glycols), poly­(caprolactones), etc .)…”

Synthesis of photothermal antimicrobial cotton gauze using AuNPs as photothermal transduction agents

“…Compared with other PTAs, AuNPs are easy to prepare, 38 and the light sources of AuNPs used for PTT could be visible light, which are easier to attain. In addition, compared with other methods reported to synthesis antimicrobial cotton gauzes, [11][12][13][14][15][16] the immersing and heating procedure used to synthesis AuNPs modied cotton gauzes is easy to operate. What's more, only a short treatment time of 40 s was needed to fully kill the microbial cells permeated in the cotton gauze, making the therapy extremely efficient.…”

“…[6][7][8][9][10] There are two basic methods to enhance the antimicrobial ability of cotton gauze: one is the chemical method, and the other is the physical method. The chemical method is incorporating antimicrobial agents, such as an antimicrobial drug, 11 metal component, 12,13 antimicrobial peptide, 8 polycation, 14 or ionic liquid 15 to enhance the antimicrobial ability. Xiang et al 12 used mussel-inspired catechol/amino chemistry to immobilize zwitterionic AgNPs on cotton gauze, and the sustained release of Ag + could give the modied cotton gauze excellent bactericidal activity.…”

Cold Atmospheric Pressure Microplasma Pipette for Disinfection of Methicillin-Resistant Staphylococcus aureus

“…To ensure that the dressing gauze effectively protects the wound tissues, new materials, including biopolymer, nanofibrous, or cellulose hydrogels, have been evaluated to enhance the biocompatibility and antibacterial effect of dressing gauzes [ 23 , 24 , 25 ]. However, micro-sized bacteria can penetrate through the dressing gauze and reach the wound area, and thus, bacterial infection and growth are still observed on the wound tissues [ 26 , 27 ]. Therefore, the wound should be kept clean to decrease the risk of contamination with microorganisms, and the dressing gauze should be regularly changed, which causes discomfort and occasionally pain [ 28 ].…”