Common genetic influences on negative emotionality and a general psychopathology factor in childhood and adolescence.

Tackett, Jennifer L.; Lahey, Benjamin B.; Hulle, Carol Van; Waldman, Irwin D.; Krueger, Robert F.; Rathouz, Paul J.

doi:10.1037/a0034151

Cited by 341 publications

(437 citation statements)

References 66 publications

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“…For example, longitudinal data will be valuable for investigating whether defi cits in cognitive control have a causal role in the co-occurrence of AUD and internalizing disorders. Further, future research could investigate whether defi cits in cognitive control increase risk for general psychopathology, as has been shown for negative emotionality (Tackett et al, 2013). Of note, if found to underlie many mental health disorders, cognitive control could be a focus of behavioral interventions, such as cognitive training (e.g., working memory training; Bickel et al, 2011;Houben et al, 2011) and mindfulness-based therapies (e.g., Baer, 2003).…”

Section: Resultsmentioning

confidence: 99%

“…Negative emotionality has been robustly associated with externalizing, internalizing, and general psychopathology (Tackett et al, 2013), and it accounts for a signifi cant proportion of the correlation between externalizing and internalizing disorders (Khan et al, 2005). To extend this work to an investigation of cognitive control, it would be informative to elucidate how negative emotionality and cognitive control, individually and together, relate to the co-occurrence of AUD and internalizing disorders.…”

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confidence: 99%

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Brief Report: Cognitive Control Helps Explain Comorbidity Between Alcohol Use Disorder and Internalizing Disorders

Ellingson¹,

Richmond‐Rakerd²,

Slutske³

2015

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Alcohol use and internalizing problems frequently co-occur. Cognitive control has been implicated in their etiology, but no studies have tested whether this construct helps explain the co-occurrence of these disorders. Method: A total of 1,313 undergraduate students completed assessments of cognitive control, negative emotionality, and symptoms of alcohol use disorder (AUD), depression, and generalized anxiety disorder. Structural equation models examined the extent to which overlap between AUD and internalizing problems was explained by variance specifi c to cognitive control and negative emotionality, as well as variance shared by both constructs. Results: Symptoms of AUD and internalizing disorders were modestly correlated (depression: r = .16; anxiety: r = .14). Variance specifi c to cognitive control explained a signifi cant proportion of the correlation between AUD and both depression and generalized anxiety (depression: 19%; generalized anxiety: 18%), as did variance common to cognitive control and negative emotionality (depression: 24%; generalized anxiety: 31%). Consistent with previous work, variance specifi c to negative emotionality also explained a large and statistically signifi cant proportion of the correlation between AUD and internalizing disorder symptoms. Of note, the residualized correlation for AUD symptom endorsement with both depression and generalized anxiety problems was not statistically significant after accounting for both cognitive control and negative emotionality. Conclusions: This study provides new evidence that cognitive control may help explain the overlap between AUD and internalizing disorders while further supporting the contribution of negative emotionality to this overlap. Results have implications for intervention efforts aimed at reducing comorbid alcohol use disorder and internalizing disorders, as well as general psychopathology. (J. Stud. Alcohol Drugs, 76, 89-94, 2015)

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Brief Report: Cognitive Control Helps Explain Comorbidity Between Alcohol Use Disorder and Internalizing Disorders

Ellingson¹,

Richmond‐Rakerd²,

Slutske³

2015

J. Stud. Alcohol Drugs

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“…High negative emotionality may reflect a general risk for psychopathology that may not be strongly specific to AUP, whereas sensation seeking may be more specific to externalizing dimensions of psychopathology (Lahey & Waldman, 2003;Rhee et al, 2015). A study of 6-to 17-yearold twin pairs found that genetic influences on a general factor of internalizing and externalizing psychopathology were correlated with those influencing negative emotionality, whereas genetic influences on the general factor and the specific externalizing factor (but not the internalizing factor) were correlated with sensation seeking (Tackett et al, 2013), indicating the possibility that there may be a more specific genetic overlap for sensation seeking and externalizing disorders. This is also consistent with prior evidence of a Type II subtype of alcohol use disorder in adults, which is characterized as being primarily driven by genetic factors, originating with an earlier onset, and frequently associated with high sensation seeking (Cloninger et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Polygenic Risk, Personality Dimensions, and Adolescent Alcohol Use Problems: A Longitudinal Study

Savage

Kendler

et al. 2017

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Alcohol use problems are common during adolescence and can predict serious negative outcomes in adulthood, including substance dependence and psychopathology. The current study examines the notion that alcohol use problems are driven by polygenic influences and that genetic influences may indirectly affect alcohol use problems through multiple pathways of risk, including variations in personality. Method: We used a genome-wide approach to examine associations between genetic risk for alcohol use problems, personality dimensions, and adolescent alcohol use problems in two separate longitudinal population-based samples, the Finnish Twin Cohort (FinnTwin12) and the Avon Longitudinal Study of Parents and Children (ALSPAC). Participants were 1,035 young adults from FinnTwin12 and 3,160 adolescents from ALSPAC. Polygenic risk scores (PRS) were calculated for ALSPAC using genome-wide association results (on alcohol dependence symptoms as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) from FinnTwin12. A parallel multiple mediator model was tested to examine whether the association between PRS and alcohol use problems assessed at age 16 could be explained by variations in personality dimensions assessed at age 13, including sensation seeking and negative emotionality. Results: PRS were marginally predictive of age 16 alcohol use problems; this association was partially mediated by sensation seeking. Polygenic variation underlying risk for alcohol use problems may directly influence the effects of sensation seeking, which in turn influence the development of alcohol use problems in later adolescence. Conclusions: These findings contribute to the increasing evidence regarding the salience of sensation seeking during early adolescence as a potential constituent in the risk pathway underlying the development of alcohol use problems. (J. Stud. Alcohol Drugs, 78, 442-451, 2017)

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“…Studies of children and adolescents also have documented the internalizing and disinhibited externalizing spectra, with some evidence suggesting a separate thought disorder dimension (Achenbach, 1966;Achenbach & Rescorla, 2001Achenbach et al, 1991;Laceulle et al, 2015;Lahey et al, 2004Lahey et al, , 2008Lahey et al, , 2011Lahey et al, , 2015Olino et al, 2014;Tackett et al, 2013). Also, some evidence suggests that certain psychopathology dimensions are already present during preschool and do not change appreciably in subsequent years (Sterba et al, 2007(Sterba et al, , 2011.…”

Section: Research and Clinical Applications Of A Quantitative Classifmentioning

confidence: 99%

The Hierarchical Taxonomy of Psychopathology (HiTOP): A Dimensional Alternative to Traditional Nosologies

Kotov¹,

Krueger²,

Watson³

et al. 2017

Preprint

509

937

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The reliability and validity of traditional taxonomies are limited by arbitrary boundaries between psychopathology and normality, often unclear boundaries between disorders, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. These taxonomies went beyond evidence available on the structure of psychopathology and were shaped by a variety of other considerations, which may explain the aforementioned shortcomings. The Hierarchical Taxonomy Of Psychopathology (HiTOP) model has emerged as a research effort to address these problems. It constructs psychopathological syndromes and their components/subtypes based on the observed covariation of symptoms, grouping related symptoms together and thus reducing heterogeneity. It also combines co-occurring syndromes into spectra, thereby mapping out comorbidity. Moreover, it characterizes these phenomena dimensionally, which addresses boundary problems and diagnostic instability. Here, we review the development of the HiTOP and the relevant evidence. The new classification already covers most forms of psychopathology. Dimensional measures have been developed to assess many of the identified components, syndromes, and spectra. Several domains of this model are ready for clinical and research applications. The HiTOP promises to improve research and clinical practice by addressing the aforementioned shortcomings of traditional nosologies. It also provides an effective way to summarize and convey information on risk factors, etiology, pathophysiology, phenomenology, illness course, and treatment response. This can greatly improve the utility of the diagnosis of mental disorders. The new classification remains a work in progress. However, it is developing rapidly and is poised to advance mental health research and care significantly as the relevant science matures.

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Common genetic influences on negative emotionality and a general psychopathology factor in childhood and adolescence.

Cited by 341 publications

References 66 publications

Brief Report: Cognitive Control Helps Explain Comorbidity Between Alcohol Use Disorder and Internalizing Disorders

Brief Report: Cognitive Control Helps Explain Comorbidity Between Alcohol Use Disorder and Internalizing Disorders

Polygenic Risk, Personality Dimensions, and Adolescent Alcohol Use Problems: A Longitudinal Study

The Hierarchical Taxonomy of Psychopathology (HiTOP): A Dimensional Alternative to Traditional Nosologies

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