Community-acquired necrotizing pneumonia with bacteremia caused by Pseudomonas aeruginosa in a patient with emphysema: An autopsy case report

Sakamoto, Naoya; Tsuchiya, Kyohei; Hikone, Mayu

doi:10.1016/j.resinv.2017.12.008

Cited by 11 publications

(14 citation statements)

References 27 publications

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“…The incidence of pleural effusion in the N-MPNP group (19 patients, 95%) was signi cantly higher than that in the MPNP group (six patients, 54.55%) (P = 0.013). Among them, two patients received bronchoscopy lavage at a maximum four times, and the cases of plastic bronchitis were seen only in the MPNP group (3 cases; P = 0.037).The length of stay was 18 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) days in the MPNP group and 23.5 (13.5-47) days in the N-MPNP group and no signi cant difference was observed between the two groups (Z = −1.923, P = −0.055).…”

Section: Resultsmentioning

confidence: 99%

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Differences of Clinical Features and Prognosis between Mycoplasma Pneumoniae Necrotizing Pneumonia and Non-Mycoplasma Pneumoniae Necrotizing Pneumonia in Children

Yang

Zhang

et al. 2021

Preprint

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BackgroundIn the past few years, Mycoplasma pneumoniae (MP) infection has been reported more in China . However, there are few studies on the clinical characteristics and prognosis of necrotizing pneumonia (NP) caused by different pathogens. MethodsA retrospective analysis was performed, including 31 children with a clinical diagnosis of NP in the hospital from January 1, 2013 to January 31, 2020. A total of 11 children with MPNP were included in the observation group and the other 20 children with other pathogens were included in the control group. The clinical manifestations, laboratory data, imaging findings, treatments and outcomes were analyzed.ResultsThe proportion of dyspnea cases was significantly higher in the non-Mycoplasma pneumoniae necrotizing pneumonia (N-MPNP) group than that in the Mycoplasma pneumoniae necrotizing pneumonia (MPNP) group (P = 0.02).The LDH level of all patients in the MPNP group was higher than the normal value, with a median value of 805.0 U/L, which was significantly higher than those in the N-MPNP group (414.0 [299.9–540.6] U/L; Z = −2.518; P = 0.012). The white blood cells (WBCs) count of the N-MPNP group was 17.8 (11.1–21.7) × 109/L, which was significantly higher than that of the MPNP group (10.2 [6.3–14.1] × 109/L; P< 0.05). The mean time of pulmonary necrosis in the MPNP group was 20.9 ±6.9 days, which was higher than that of the N-MPNP group (16.8 ±6.1 days; t = 3.101; P = 0.004). The incidence of pleural effusion in the N-MPNP group (19 patients, 95%) was significantly higher than that in the MPNP group (six patients, 54.55%) (P = 0.013). Among them, two patients received bronchoscopy lavage at a maximum four times, and the cases of plastic bronchitis were seen only in the MPNP group (3 cases; P = 0.037).The length of stay was 18 (10–22) days in the MPNP group and 23.5 (13.5–47) days in the N-MPNP group and no significant difference was observed between the two groups (Z = −1.923, P = −0.055).Conclusions1. MP infection is the most common infection in children with NP in the Suzhou area. There is no gender and age difference between MPNP and N-MPNP, but the bacterial infection was mainly observed in the N-MPNP group.2. Children in the N-MPNP group have more severe clinical symptoms, were more prone to shortness of breath, had a longer hospital stay, and had earlier imaging manifestations of necrosis, whereas children in the MPNP group were more likely to have plastic bronchitis. The level of WBC and LDH and the nature of pleural effusion can be used to identify MPNP and N-MPNP to some extent.3. The prognosis of MPNP was better than that of N-MPNP. There were no death cases. Pleural thickening, pulmonary fibrosis, and bronchiectasis were the most common sequelae. Compared with N-MPNP, the recovery time of lung imaging in MPNP was shorter.

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Section: Resultsmentioning

confidence: 99%

“…In recent years, there are several studies on NP in children [13][14][15]; however, there are few reports on NP caused by different pathogens. Streptococcus pneumoniae and Staphylococcus aureus are the most common pathogens that cause NP in children, and MPNP has been reported mostly in China in the last few years.…”

Section: Discussionmentioning

confidence: 99%

Differences of Clinical Features and Prognosis between Mycoplasma Pneumoniae Necrotizing Pneumonia and Non-Mycoplasma Pneumoniae Necrotizing Pneumonia in Children

Yang

Zhang

et al. 2021

Preprint

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“…In the literature, we found 13 cases of necrotizing CAP due to P. aeruginosa associated with cavitation. Table 1 summarizes the 11 most recent cases [[1], [2], [3], [4], [5], [6], [7], [8], [9], [10]]. The main risk factors for necrotizing CAP due to P. aeruginosa are: lung structural abnormalities (including cystic fibrosis, emphysema, bronchial dilatation, chronic obstructive pulmonary disease), immunocompromised condition (including neoplasia, neutropenia, prolonged antibacterial therapy, immunosuppression), and exposure to contaminated liquids (including hot tub, spa, humidifier) [1,2].…”

Section: Discussionmentioning

confidence: 99%

“…Regarding antimicrobial management for CAP, the literature is summarized in Table 1 [[1], [2], [3], [4], [5], [6], [7], [8], [9], [10]]. It is generally not appropriate to administer empiric anti-Pseudomonas therapy.…”

Section: Discussionmentioning

confidence: 99%

Septic shock secondary to an acute necrotizing community-acquired pneumonia with bacteremia due to Pseudomonas aeruginosa

Rivière¹,

Patin²,

Delaporte³

et al. 2019

IDCases

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Highlights Necrotizing acute community-acquired pneumonia due to Pseudomonas aeruginosa are rare. Second description of a septic shock secondary to a necrotizing CAP with bacteremia due to P. aeruginosa for which pulmonary origin was proven by bronchoalveolar lavage fluid on a patient who survived. Anti-pseudomonal monotherapy may be may be a better option for older patients Despite risk factors related to the host or to the bacteria, the evolution remains unpredictable.

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“…The opportunistic Gram‐negative Pseudomonas aeruginosa bacterium is associated with high morbidity rate of many chronic and acute infections including pneumonia, [ 1 ] cystic fibrosis, [ 2 ] chronic otitis, [ 3 ] burn injuries, [ 4 ] and urinary tract infections. [ 5 ] Additionally, it displays an intrinsic resistance to several antibiotics due to its restricted cell permeability as well as expression of efflux systems that expel antibiotics out of the cell.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of imidazolidine‐2,4‐dione and 2‐thioxoimidazolidin‐4‐one derivatives as inhibitors of virulence factors production in Pseudomonas aeruginosa

Mohamed

Abdel‐Samii

Abdel‐Aal

et al. 2020

Archiv der Pharmazie

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In an attempt to counteract bacterial pathogenicity, a set of novel imidazolidine-2,4dione and 2-thioxoimidazolidin-4-one derivatives was synthesized and evaluated as inhibitors of bacterial virulence. The new compounds were characterized and screened for their effects on the expression of virulence factors of Pseudomonas aeruginosa, including protease, hemolysin, and pyocyanin. Imidazolidine-2,4-diones 4c, 4j, and 12a showed complete inhibition of the protease enzyme, and they almost completely inhibited the production of hemolysin at 1/4 MIC (1/4 minimum inhibitory concentration; 1, 0.5, and 0.5 mg/ml, respectively). 2-Thioxoimidazolidin-4-one derivative 7a exhibited the best inhibitory activity (96.4%) against pyocyanin production at 1 mg/ml (1/4 MIC). A docking study was preformed to explore the potential binding interactions with quorum-sensing receptors (LasR and RhlR), which are responsible for the expression of virulence genes. K E Y W O R D S2-thioxoimidazolidin-4-one, imidazolidine-2,4-dione, Pseudomonas aeruginosa, quorum sensing, virulence inhibition

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Community-acquired necrotizing pneumonia with bacteremia caused by Pseudomonas aeruginosa in a patient with emphysema: An autopsy case report

Cited by 11 publications

References 27 publications

Differences of Clinical Features and Prognosis between Mycoplasma Pneumoniae Necrotizing Pneumonia and Non-Mycoplasma Pneumoniae Necrotizing Pneumonia in Children

Differences of Clinical Features and Prognosis between Mycoplasma Pneumoniae Necrotizing Pneumonia and Non-Mycoplasma Pneumoniae Necrotizing Pneumonia in Children

Septic shock secondary to an acute necrotizing community-acquired pneumonia with bacteremia due to Pseudomonas aeruginosa

Synthesis of imidazolidine‐2,4‐dione and 2‐thioxoimidazolidin‐4‐one derivatives as inhibitors of virulence factors production in Pseudomonas aeruginosa

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