Community-acquired pneumonia as the initial manifestation of serious underlying diseases

Falguera, Miquel; Martín, Mariela; Ruiz-González, Agustı́n; Pifarré, R.; García, M.

doi:10.1016/j.amjmed.2005.01.011

Cited by 24 publications

(16 citation statements)

References 17 publications

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“…Community-acquired pneumonia is the most common complication of COPD exacerbation. 10 Some studies have carefully examined whether patients with community-acquired pneumonia and COPD present differences in clinical manifestations, etiology, or outcome, with special emphasis on mortality compared to those that do not have COPD. 11,12 To our knowledge, the present study is the first to compare the clinical features, etiological distribution, and treatment outcomes of patients with COPD exacerbation versus patients with community-acquired pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Bacteriological Differences Between COPD Exacerbation and Community-Acquired Pneumonia

et al. 2011

Respir Care

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OBJECTIVE: To study the differences in pathogen distribution and antibiotic susceptibility between patients with COPD exacerbation and patients with community-acquired pneumonia, and develop guidance for antibiotic treatment of those conditions. METHODS: We retrospectively analyzed the medical records of 586 COPD-exacerbation patients and 345 community-acquiredpneumonia patients from January 2007 to December 2008, including sputum culture results, antibiotic susceptibilities of the microorganisms, and clinical characteristics. RESULTS: 276 (47%) of the COPD-exacerbation patients, and 183 (53%) of the community-acquired-pneumonia patients had a positive sputum culture. In order, the most common pathogens in the COPD-exacerbation patients were Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Acinetobacter baumannii, and Haemophilus influenzae. The most common pathogens in the community-acquired-pneumonia patients were Streptococcus pneumoniae, H. influenzae, K. pneumoniae, S. aureus, and E. coli. CONCLUSIONS: P. aeruginosa was the most common pathogen in our patients with COPD exacerbation, and S. pneumoniae was the most common in our patients with community-acquired pneumonia. P. aeruginosa is especially common in the patients with serious or extremely serious COPD.

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Section: Discussionmentioning

confidence: 99%

Bacteriological Differences Between COPD Exacerbation and Community-Acquired Pneumonia

et al. 2011

Respir Care

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“…Diabetes mellitus is associated with an increased susceptibility to infection and is the most frequently recognized coexisting illness in patients with community-acquired respiratory tract infections (13). Thus, we studied telithromycin in both rat models of DMIA and DMIS.…”

Section: Introductionmentioning

confidence: 99%

Telithromycin Pharmacokinetics in Rat Model of Diabetes Mellitus Induced by Alloxan or Streptozotocin

Lee

2008

Pharm Res

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“…It has been reported that diabetes mellitus is associated with an increased susceptibility to microbial infection and is the most frequently recognized coexisting illness in patients with community-acquired respiratory tract infection (Falguera et al 2005). Compared with control rats, the protein expression and/or mRNA level of hepatic CYP3A1/2 increased in male Sprague-Dawley rats with diabetes mellitus induced by streptozotocin (rat model of DMIS) (Shimojo et al 1993;Kim et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic interaction between telithromycin and metformin in diabetes mellitus rats

2009

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Telithromycin and metformin have been reported to be commonly metabolized via hepatic CYP3A1/2 in rats. Community-acquired respiratory tract infection was reported to be frequent in patients with diabetes mellitus. Compared with controls, hepatic CYP3A1/2 was reported to be increased in male rats with diabetes mellitus induced by streptozotocin (DMIS rats). After the intravenous administration of both drugs together to male DMIS rats, the time-averaged non-renal clearance (CL(NR)) of metformin was significantly slower (by 33.1%; 10.3 versus 15.4 ml min(-1) kg(-1)) than metformin alone due to the inhibition of hepatic metabolism of metformin by telithromycin via CYP3A1/2. After the oral administration of both drugs together, the total area under the plasma concentration-time curve (AUC) of metformin was comparable possibly due to the increased intestinal metabolism of metformin by telithromycin.

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Community-acquired pneumonia as the initial manifestation of serious underlying diseases

Cited by 24 publications

References 17 publications

Bacteriological Differences Between COPD Exacerbation and Community-Acquired Pneumonia

Bacteriological Differences Between COPD Exacerbation and Community-Acquired Pneumonia

Telithromycin Pharmacokinetics in Rat Model of Diabetes Mellitus Induced by Alloxan or Streptozotocin

Pharmacokinetic interaction between telithromycin and metformin in diabetes mellitus rats

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