Compact self-wiring in cultured neural networks

Sorkin, Raya; Gabay, Tamir; Blinder, Pablo; Baranes, Danny; Ben‐Jacob, Eshel; Hanein, Yael

doi:10.1088/1741-2560/3/2/003

Cited by 79 publications

(80 citation statements)

References 32 publications

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“…The cells connect and form clusters at the CNT electrodes which is comparable to the observations made by [23]. Electrophysiological experiments with the neural cell culture systems will follow in the near future.…”

Section: Resultssupporting

confidence: 77%

Three-Dimensional Carbon Nanotube Electrodes for Extracellular Recording of Cardiac Myocytes

et al. 2012

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Low impedance at the interface between tissue and conducting electrodes is of utmost importance for the electrical recording or stimulation of heart and brain tissue. A common way to improve the cell-metal interface and thus the signal-to-noise ratio of recordings, as well as the charge transfer for stimulation applications, is to increase the electrochemically active electrode surface area. In this paper, we propose a method to decrease the impedance of microelectrodes by the introduction of carbon nanotubes (CNTs), offering an extremely rough surface. In a multistage process, an array of multiple microelectrodes covered with high quality, tightly bound CNTs was realized. It is shown by impedance spectroscopy and cardiac myocyte recordings that the transducer properties of the carbon nanotube electrodes are superior to conventional gold and titanium nitride electrodes. These findings will be favorable for any kind of implantable heart electrodes and electrophysiology in cardiac myocyte cultures.

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Section: Resultssupporting

confidence: 77%

Three-Dimensional Carbon Nanotube Electrodes for Extracellular Recording of Cardiac Myocytes

et al. 2012

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“…[327][328][329][330][331][332][333][334][335][336] Though surface topography and chemistry interact in a complex synergistic manner, [337,338] topographical cues alone [339] are able to exert considerable influence over the cells they contact. [257,326,340,341] Topographic stimuli appear to affect both neural and nonneuronal cell types, and different topographies exert varying effects on adherent cells.…”

Section: Topographymentioning

confidence: 99%

Nanomaterials for Neural Interfaces

et al. 2009

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This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the electronic properties of nanostructures can be tailored to match the charge transport requirements of electrical cellular interfacing. (ii) The unique mechanical and chemical properties of nanomaterials are critical for integration with neural tissue as long‐term implants. (iii) Solutions to many critical problems in neural biology/medicine are limited by the availability of specialized materials. (iv) Neuronal stimulation is needed for a variety of common and severe health problems. This confluence of need, accumulated expertise, and potential impact on the well‐being of people suggests the potential of nanomaterials to revolutionize the field of neural interfacing. In this review, we begin with foundational topics, such as the current status of neural electrode (NE) technology, the key challenges facing the practical utilization of NEs, and the potential advantages of nanostructures as components of chronic implants. After that the detailed account of toxicology and biocompatibility of nanomaterials in respect to neural tissues is given. Next, we cover a variety of specific applications of nanoengineered devices, including drug delivery, imaging, topographic patterning, electrode design, nanoscale transistors for high‐resolution neural interfacing, and photoactivated interfaces. We also critically evaluate the specific properties of particular nanomaterials—including nanoparticles, nanowires, and carbon nanotubes—that can be taken advantage of in neuroprosthetic devices. The most promising future areas of research and practical device engineering are discussed as a conclusion to the review.

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“…In addition, the communication between neurites of neurons attached to different nanotube-containing domains induce a mechanical tension in the neuronal network, which serves as a signal for survival of the axonal branch and perhaps for the subsequent formation of synapses (Eliason et al, 2008). Neuronal networks developed on surfaces micropatterned with CNT domains can be utilized not only for neural tissue engineering, but also as advanced neuro-chips for bio-sensing applications, e.g., drug and toxin detection (Sorkin et al, 2006). Carbon nanotube films can be deposited not only on planar 2D substrates, but also on threedimensional matrices, i.e., on the walls of pores inside sponge-like collagenous scaffolds for bone tissue engineering.…”

Section: Carbon Nanotubesmentioning

confidence: 99%