Companion Animals as Reservoirs ofeaeA+Escherichia Coli

Holland, Margo S.; Kennedy, Frances A.; Holland, Robert E.

doi:10.1177/104063870001200117

Cited by 4 publications

(9 citation statements)

References 26 publications

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“…Diarrhoea associated with naturally occurring AE lesions has been reported in pigs from the neonatal to the post-weaning period (Janke et al, 1989;Wada et al, 1996b;Higgins et al, 1997;Holland et al, 2000), and there is some evidence that diet may play a part in the occurrence of such lesions (Neef et al, 1994). Diarrhoea may be haemorrhagic (Janke et al, 1989), but gross findings typically are unremarkable (Janke et al, 1989;Higgins et al, 1997) and isolates rarely produce VT (Janke et al, 1989;Zhu et al, 1994;Higgins et al, 1997).…”

Section: Pigsmentioning

confidence: 99%

“…Diarrhoea may be haemorrhagic (Janke et al, 1989), but gross findings typically are unremarkable (Janke et al, 1989;Higgins et al, 1997) and isolates rarely produce VT (Janke et al, 1989;Zhu et al, 1994;Higgins et al, 1997). AE lesions may be present in the small or large intestines, or in both (Janke et al, 1989;Higgins et al, 1997;Holland et al, 2000). In the field, dual infection of the small and large intestines of weaned pigs with ETEC O149 and AEEC O45 has been reported (Wada et al, 1996b).…”

Section: Pigsmentioning

confidence: 99%

“…Several other serogroups, including O26, O75, O116 and O K , have been reported in association with AEEC in pigs (Neef et al, 1994;Higgins et al, 1997;Holland et al, 2000). Porcine diarrhoeaassociated E. coli strains of various serogroups that produce the FAS reaction and AE lesions in vitro, but which are negative in conventional tests for eae and intimin, have been reported (Penteado et al, 2001).…”

Section: Pigsmentioning

confidence: 99%

“…Domestic carnivores. The literature contains reports of 15 cases of canine enteritis associated with AEEC and verified by histopathology and electron microscopy (Broes et al, 1988;Drolet et al, 1994a;Wada et al, 1996a;Holland et al, 2000). The 15 animals were young, usually less than 3 months of age and none exceeding 5 months.…”

Section: Other Mammalsmentioning

confidence: 99%

“…The 15 animals were young, usually less than 3 months of age and none exceeding 5 months. Diarrhoea, which was invariably present, was often chronic (Broes et al, 1988;Wada et al, 1996a;Holland et al, 2000) and non-haemorrhagic (Drolet et al, 1994a). Typically the dogs were seriously ill and concurrently infected with one or more other agents (distemper virus, parvovirus, coccidia, Giardia and Cryptosporidium).…”

Section: Other Mammalsmentioning

confidence: 99%

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Attaching-effacing Bacteria in Animals

Wales

Woodward²,

Pearson

2005

Journal of Comparative Pathology

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Enteric bacteria with a demonstrable or potential ability to form attaching-effacing lesions, so-called attaching-effacing (AE) bacteria, have been found in the intestinal tracts of a wide variety of warm-blooded animal species, including man. In some host species, for example cattle, pigs, rabbits and human beings, attaching-effacing Escherichia coli (AEEC) have an established role as enteropathogens. In other host species, AE bacteria are of less certain significance. With continuing advances in the detection and typing of AE strains, the importance of these bacteria for many hosts is likely to become clearer. The pathogenic effects of AE bacteria result from adhesion to the intestinal mucosa by a variety of mechanisms, culminating in the formation of the characteristic intimate adhesion of the AE lesion. The ability to induce AE lesions is mediated by the co-ordinated expression of some 40 bacterial genes organized within a so-called pathogenicity island, known as the "Locus for Enterocyte Effacement". It is also believed that the production of bacterial toxins, principally Vero toxins, is a significant virulence factor for some AEEC strains. Recent areas of research into AE bacteria include: the use of Citrobacter rodentium to model human AEEC disease; quorum-sensing mechanisms used by AEEC to modulate virulence gene expression; and the potential role of adhesion in the persistent colonization of the intestine by AE bacteria. This review of AE bacteria covers their molecular biology, their occurrence in various animal species, and the diagnosis, pathology and clinical aspects of animal diseases with which they are associated. Reference is made to human pathogens where appropriate. The focus is mainly on natural colonization and disease, but complementary experimental data are also included.

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Section: Pigsmentioning

confidence: 99%

Section: Pigsmentioning

confidence: 99%

Section: Pigsmentioning

confidence: 99%

Section: Other Mammalsmentioning

confidence: 99%

Section: Other Mammalsmentioning

confidence: 99%

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Attaching-effacing Bacteria in Animals

Wales

Woodward²,

Pearson

2005

Journal of Comparative Pathology

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Comparison of Escherichia coli Isolates from Humans, Food, and Farm and Companion Animals for Presence of Shiga Toxin–Producing E. coli Virulence Markers

Murinda

Nguyen²,

Landers³

et al. 2004

Foodborne Pathogens and Disease

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The objective of this study was to characterize Escherichia coli isolates from dairy cows/feedlots, calves, mastitis, pigs, dogs, parrot, iguana, human disease, and food products for prevalence of Shiga toxin-producing E. coli (STEC) virulence markers. The rationale of the study was that, isolates of the same serotypes that were obtained from different sources and possessed the same marker profiles, could be cross-species transmissible. Multiplex polymerase chain reaction (PCR) was used to detect presence of genes encoding Shiga toxin 1 and 2 (stx1 and stx2), H7 flagella (flicC), enterohemolysin (hly) and intimin (eaeA) in E. coli isolates (n = 400). Shiga toxin-producing isolates were tested for production of Shiga toxins (Stx1 and Stx2 and enterohemolysin. Of the E. coli O157:H7/H- strains, 150 of 164 (mostly human, cattle, and food) isolates were stx+. Sixty-five percent of O157 STEC produced both Stx1 and Stx2; 32% and 0.7% produced Stx2 or Stx1, respectively. Ninety-eight percent of O157 STEC had sequences for genes encoding intimin and enterohemolysin. Five of 20 E. coli O111, 4 of 14 O128 and 4 of 10 O26 were stx+ . Five of 6 stx+ O26 and O111 produced Stx1, however, stx+ O128 were Stx-negative. Acid resistance (93.3%) and tellurite resistance (87.3%) were common attributes of O157 STEC, whereas, non-O157 stx+ strains exhibited 38.5% and 30.8% of the respective resistances. stx-positive isolates were mostly associated with humans and cattle, whereas, all isolates from mastitis (n = 105), and pigs, dogs, parrot and iguanas (n = 48) were stx-negative. Multiplex PCR was an effective tool for characterizing STEC pathogenic profiles and distinguished STEC O157:H7 from other STEC. Isolates from cattle and human disease shared similar toxigenic profiles, whereas isolates from other disease sources had few characteristics in common with the former isolates. These data suggest interspecies transmissibility of certain serotypes, in particular, STEC O157:H7, between humans and cattle.

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Identification of eae genes in Escherichia coli strains isolated from pigs with postweaning diarrhoea

Osek

2001

Veterinary Record

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Companion Animals as Reservoirs ofeaeA⁺Escherichia Coli

Cited by 4 publications

References 26 publications

Attaching-effacing Bacteria in Animals

Attaching-effacing Bacteria in Animals

Comparison of Escherichia coli Isolates from Humans, Food, and Farm and Companion Animals for Presence of Shiga Toxin–Producing E. coli Virulence Markers

Identification of eae genes in Escherichia coli strains isolated from pigs with postweaning diarrhoea

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