Comparação da sobrevivência e dos fatores prognósticos em pacientes com adenocarcinoma gástrico T2 e T3

Juca, Patricia; Lourenço, Laércio Gomes; Kesley, Rubens; Mello, Eduardo Linhares Riello de; Oliveira, Ivanir Martins de; Correa, José Humberto Simões

doi:10.1590/s0100-69912012000500007

Cited by 6 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the past few decades, intensive efforts have been made to identify tools to improve prognostication of GC. However, besides cancer staging, on which adjuvant treatment currently depends, there are few prognostic factors for the prognosis of GC [4,5,6]. Data prove that, in GC, pretreatment serum levels of carcinoma embryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) have a prognostic value, and they should be considered when evaluating different therapeutic protocols [7].…”

Section: Introductionmentioning

confidence: 99%

Expression of Eukaryotic Initiation Factor 3f Is Associated with Prognosis in Gastric Carcinomas

Cheng¹,

Jia

et al. 2014

Oncol Res Treat

View full text Add to dashboard Cite

Background: Eukaryotic initiation factor 3f (eIF3f) expression, which plays an important role in human cancer, is significantly decreased in various types of cancers. The aim of this study was to detect the expression of eIF3f in gastric carcinoma (GC), which until now has not been reported. Methods: Expression of eIF3f was detected by immunohistochemistry in GC tissues and adjacent non-cancerous tissues (ANCT) from 195 patients with stage I-III GC who underwent curative gastrectomy. Clinicopathological results, including survival, were analyzed. Results: Expression rate of eIF3f in GC and ANCT were 44.8 and 81.7% respectively. Low expression of eIF3f was significantly associated with an increased serum level of carcinoma embryonic antigen (p = 0.02), but not with levels of carbohydrate antigen 19-9 (p = 0.29). eIF3f levels were linked to more advanced tumor stages and likelihood of recurrence (all p < 0.05).The Kaplan-Meier survival curves indicated that decreased expression of eIF3f was a significant factor for a poor prognosis for GC patients (p = 0.04). Conclusion: eIF3f may play an important role in recurrence. Its function and potential as a prognostic marker should be further verified in GC.

show abstract

Section: Introductionmentioning

confidence: 99%

Expression of Eukaryotic Initiation Factor 3f Is Associated with Prognosis in Gastric Carcinomas

Cheng¹,

Jia

et al. 2014

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

Evaluation of the seventh AJCC TNM staging system for gastric cancer: a meta-analysis of cohort studies

et al. 2014

View full text Add to dashboard Cite

The AJCC seventh edition TNM classification for gastric cancer was released in 2010 and included major revision. Large-volume gastric cancer centers have evaluated the prognostic significance of the new system and obtained paradoxical results. The authors performed a meta-analysis of these studies to evaluate the new classification. Fifteen eligible studies with 38,972 patients were included in the analysis. Hazard ratios (HRs) and associated 95 % confidence intervals were extracted from identified studies. The primary outcome was overall survival. The HRs for the seventh edition T classification and N classification were found to increase steadily and reasonably. The cumulative survival rates of the seventh edition subgroups of T classifications demonstrated obvious differences; meanwhile, the differences between subgroups of N classifications including N3a and N3b categories were also significant. The 5-year survival rates according to the seventh edition TNM staging system were 94.71 % (stage IA), 88.72 % (stage IB), 80.45 % (stage IIA), 67.24 % (stage IIB), 53.68 % (stage IIIA), 37.56 % (stage IIIB), and 21.26 % (stage IIIC), respectively. The results of this study indicate that the seventh edition of the TNM classification was considered valid, although further evaluation was needed for N3a and N3b categories.

show abstract

Multimodale Therapie beim lokal begrenzten Magenkarzinom

Ertl¹,

Ståhl

2014

Im Focus Onkologie

View full text Add to dashboard Cite

Comparação da sobrevivência e dos fatores prognósticos em pacientes com adenocarcinoma gástrico T2 e T3

Abstract: The lymph node status and tumor size are independent prognostic factors in tumors with invasion of the muscularis propria and in tumors with invasion of subserosa. T2 lesions have smaller size, lower rate of lymph node metastasis and therefore better prognosis than T3.

Cited by 6 publications

References 20 publications

Expression of Eukaryotic Initiation Factor 3f Is Associated with Prognosis in Gastric Carcinomas

Expression of Eukaryotic Initiation Factor 3f Is Associated with Prognosis in Gastric Carcinomas

Evaluation of the seventh AJCC TNM staging system for gastric cancer: a meta-analysis of cohort studies

Multimodale Therapie beim lokal begrenzten Magenkarzinom

Contact Info

Product

Resources

About