Global climate change and human activities have profoundly affected the hydrological processes in the basin. The study of the characteristics of runoff and sediment variations in the basin and their driving factors is of great significance in promoting the efficient use of water resources and high-quality development in the basin. The determination of the abrupt change point of the runoff-sediment relationship is the key to delineate the base period, and is important to assess the contribution of climate change and human activities to the change of the runoff-sediment relationship. Therefore, this study constructs a binary coupled coordination model of runoff and sediment load to describe the coupled runoff-sediment coordination relationship, and uses the Pettitt method and the double cumulative curve method to test for mutations. The effects of climate change and human activities on changes in runoff and sediment load were assessed using the Budyko framework-based elasticity factor method and the cumulative slope rate of change method. The results show that the