Comparative Analysis of Peptide Composition and Bioactivity of Different Collagen Hydrolysate Batches on Human Osteoarthritic Synoviocytes

Simons, Viktor S.; Lochnit, Guenter; Wilhelm, Jochen; Ishaque, Bernd; Rickert, Markus; Steinmeyer, Jürgen

doi:10.1038/s41598-018-36046-3

Cited by 17 publications

(15 citation statements)

References 35 publications

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“…Hence, the heterogeneous peptide composition and disparate possible pharmacological effects between various collagen hydrolysate sources suggest that the effect of a specific preparation cannot always be extrapolated to other formulations. This observation has been verified using different technologies in other studies comparing different source collagen hydrolysates that have similarly demonstrated different CH preparations can differ significantly in their peptide composition [76][77][78].…”

Section: Discussionsupporting

confidence: 61%

A Review of the Literature Relating to Collagen Hydrolysate and Its Potential Clinical Applications

Wakeman

2021

JAMMR

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The increasing commercial necessity to valorise commodities such as gelatine has led to significant developments in its processing and the outcome of these refinements has resulted in new applications in fields such as pharmaceuticals, medical devices, cosmetics, food and nutraceuticals. This in turn has led to the investigation of alternative sources of compounds with collagen-like properties, other than the conventionally used raw materials from mammalian species. Moreover, the current desire to seek natural, rather than synthetic compounds-especially regarding oral consumption and/or topical application-combined with the ability of gelatine derived products to form gels with varying degrees of flexibility and hydroplasticity has also accelerated research into previously unexplored applications. In the food sector, these include:- use of gelatine derivatives as an encapsulating agent (including the development of micro-beads as carriers of active compounds) foaming agents, emulsifiers, biodegradable films, colloid stabilizers and as nutraceuticals. The latter sector has especially benefitted from developments in enzymatic hydrolysis processes, where specific and highly characterised bioactive peptides often containing the amino acid hydroxyproline are end-products which have been identified to be orally bioavailable and metabolised and hence likely to deliver potential clinical benefits. This review examines manufacturing processes employed to typically produce hydrolysed collagen, evaluates studies examining bioavailability, metabolism and likely health benefits as well as potential clinical applications as a nutraceutical.

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Section: Discussionsupporting

confidence: 61%

A Review of the Literature Relating to Collagen Hydrolysate and Its Potential Clinical Applications

Wakeman

2021

JAMMR

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“…Another issue that needs to be clarified is the role of the source of collagen and manufacturing processes on its therapeutic effects. In fact, it has been reported that different CH may have different peptide composition [43,44,88] and exhibit different effects on articular cartilage [43,44]. It may therefore be important to differentiate collagen derivatives according to source of collagen and manufacturing procedures.…”

Section: Discussionmentioning

confidence: 99%

Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping

et al. 2020

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Introduction: There is currently no diseasemodifying drug for osteoarthritis (OA), and some safety concerns have been identified about the leading traditional drugs. Therefore, research efforts have focused on alternatives such as supplementation with collagen derivatives. The objective of this scoping review is to examine the extent, range, and nature of research, and to summarize and disseminate research findings on the effects of collagen

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“…Currently, there is no effective treatment for OA, only the therapy that slows or prevents OA progression [ 6 , 8 ]. So far most of the treatment methods (prescribing analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs)) have focused on relieving pain and improving joint function without the possibility of solving the problem of the OA progression and complications [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Chondroprotection and Molecular Mechanism of Action of Phytonutraceuticals on Osteoarthritis

et al. 2021

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Osteoarthritis (OA) is a degenerative joint disease and an important cause of incapacitation. There is a lack of drugs and effective treatments that stop or slow the OA progression. Modern pharmacological treatments, such as analgesics, have analgesic effects but do not affect the course of OA. Long-term use of these drugs can lead to serious side effects. Given the OA nature, it is likely that lifelong treatment will be required to stop or slow its progression. Therefore, there is an urgent need for disease-modifying OA treatments that are also safe for clinical use over long periods. Phytonutraceuticals are herbal products that provide a therapeutic effect, including disease prevention, which not only have favorable safety characteristics but may have an alleviating effect on the OA and its symptoms. An estimated 47% of OA patients use alternative drugs, including phytonutraceuticals. The review studies the efficacy and action mechanism of widely used phytonutraceuticals, analyzes the available experimental and clinical data on the effect of some phytonutraceuticals (phytoflavonoids, polyphenols, and bioflavonoids) on OA, and examines the known molecular effect and the possibility of their use for chondroprotection.

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Comparative Analysis of Peptide Composition and Bioactivity of Different Collagen Hydrolysate Batches on Human Osteoarthritic Synoviocytes

Cited by 17 publications

References 35 publications

A Review of the Literature Relating to Collagen Hydrolysate and Its Potential Clinical Applications

A Review of the Literature Relating to Collagen Hydrolysate and Its Potential Clinical Applications

Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping

Chondroprotection and Molecular Mechanism of Action of Phytonutraceuticals on Osteoarthritis

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