2006
DOI: 10.1002/cne.21214
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Comparative analysis of the subcellular and subsynaptic localization of mGluR1a and mGluR5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkey

Abstract: Group I metabotropic glutamate receptors (mGluRs) play critical roles in synaptic plasticity and drug addiction. To characterize potential sites whereby these receptors mediate their effects in the ventral striatum, we studied the subcellular and subsynaptic localization of mGluR1a and mGluR5 in the shell and core of the nucleus accumbens in rat and monkey. In both species, group I mGluRs are mainly postsynaptic in dendrites and spines, with rare presynaptic labeling in unmyelinated axons. Minor, yet significa… Show more

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Cited by 71 publications
(97 citation statements)
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References 95 publications
(144 reference statements)
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“…Tissue from all three cocaine treatment groups and saline-treated animals were immunostained for the two group I mGluRs. In line with our previous study, the immunoreactivity for mGluR1a and mGluR5 was distributed heavily in the neuropil of the shell and core of the accumbens, with very light labeling in cell bodies (Mitrano and Smith, 2007). No obvious difference in the overall distribution of mGluR1a and mGluR5 immunoreactivity was found in the nucleus accumbens between cocaine-and saline-treated rats (data not shown).…”
Section: Light Microscopic Observationssupporting
confidence: 92%
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“…Tissue from all three cocaine treatment groups and saline-treated animals were immunostained for the two group I mGluRs. In line with our previous study, the immunoreactivity for mGluR1a and mGluR5 was distributed heavily in the neuropil of the shell and core of the accumbens, with very light labeling in cell bodies (Mitrano and Smith, 2007). No obvious difference in the overall distribution of mGluR1a and mGluR5 immunoreactivity was found in the nucleus accumbens between cocaine-and saline-treated rats (data not shown).…”
Section: Light Microscopic Observationssupporting
confidence: 92%
“…As shown in our previous study (Mitrano and Smith, 2007) and others (Meredith et al, 1996), calbindin immunoreactivity clearly delineated the boundaries of the shell and core of the nucleus accumbens, hence serving as a guide for the selection of blocks of tissue in subsequent electron microscopic experiments. Tissue from all three cocaine treatment groups and saline-treated animals were immunostained for the two group I mGluRs.…”
Section: Light Microscopic Observationssupporting
confidence: 68%
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“…As for mGluR5, our observations of somatodendritic distribution in the order of spine Ͼ dendritic shaft Ͼ soma, predominant extrasynaptic expression, and perisynaptic accumulation at asymmetrical synapses are consistent with previous studies (Paquet and Smith, 2003;Mitrano and Smith, 2007). This molecular organization will explain the electrophysiological findings that corticostriatal excitatory transmission is suppressed by CB 1 agonists (Gerdeman and Lovinger, 2001;Huang et al, 2001) and that DSE and endocannabinoiddependent LTD are induced in MS neurons only when postsynaptic depolarization or L-type calcium channel activation is combined with group I mGluR activation (Kreitzer and Malenka, 2005;Narushima et al, 2006a) (Fig.…”
Section: -Ag-mediated Retrograde Suppression At Corticostriatal Synapsesupporting
confidence: 91%
“…DAG lipase-␣ (DAGL␣) is targeted selectively to somatodendritic compartments and concentrated around spines (Katona et al, 2006;Yoshida et al, 2006), as is the case for group I mGluRs and PLC␤ (Baude et al, 1993;Lujan et al, 1996;Nakamura et al, 2004;Mitrano and Smith, 2007). Indeed, DAG lipase inhibitors have been shown to abolish ERS in dopaminergic neurons and Purkinje cells (Melis et al, 2004;Safo and Regehr, 2005;Szabo et al, 2006).…”
Section: Introductionmentioning
confidence: 99%