“…[10] In the present study, we attached HYNIC as bifunctional chelator to the N-terminal of the peptide J18 for radiolabeling with 99m Tc. This result is in contrast to previous studies [11,22] where high hydrophilicity and low protein binding were achieved using EEDA/tricine as coligands. [12,13] It has been noted that some properties of the 99m Tc-labeled peptide, such as lipophilicity, stability, and protein-binding potential, are affected by the nature of the coligand.…”