Comparative assessment of wound healing by using a local flap and full-thickness skin graft  in reconstructive head and neck surgery

Ларичев, А. Б.; Chistyakov, A. L.; Komlev, V. L.

doi:10.17650/2408-9613-2016-3-2-37-46

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Анализ структуры и свойств возбудителей раневых инфекций при выполнении свободной кожной JOURNAL OF EXPERIMENTAL AND CLINICAL SURGERY 2019 45 (4) ORIGINAL STUDY пластики и оптимизации выбора препаратов для стартовой эмпирической антибактериальной терапии.…”

Section: цельunclassified

“…Микстинфекция в ране с осложненным процессом заживления была представлена S. aureus и P. aureginosa в 29% случаев, сочетанием одного из этих возбудителей с A. baumannii -29% или с различными видами родов Streptococcus и Enterobacter -21% случаев. На результат свободной кожной пластики расщепленным трансплантатом влияют несколько факторов: кровоснабжение реципиентного ложа [4], техника выполнения операции, толщина кожного трансплантата [10], свойства местных лекарственных средств, входящих в состав повязки, накладываемой на рану [8,9]. Но одним из самых значимых факторов является микробный пейзаж хронической раны [7].…”

Section: оригинальное исследованиеunclassified

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The results of monitoring the dynamics and antibiotic resistance of microflora when performing split-skin grafting in a general surgical hospital

Pavlenko¹,

Кичин²,

Бесчастнов³

2019

VECS

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Relevance. One of the effective ways to close chronic wounds according to many authors is split-skin grafting. To obtain good results of plastic operations, a constant monitoring of the structure of microbiological associations of chronic wounds and their sensitivity to antimicrobial agents is necessary. Aim. Analysis of the structure and properties of pathogens of wound infections when performing split-skin grafting and optimizing the choice of drugs for starting empirical antibacterial therapy. Materials and methods. A retrospective analysis of the results of microbiological studies was conducted in 86 patients who underwent split-skin grafting. For statistical processing of the data obtained, the computer program Statistica 6.0 was used. Results. Microbial contamination in patients on admission to hospital was (Me [Q1; Q3]) 106 [102; 108] CFU/ml. Unsatisfactory results of split-skin grafting were noted in 15 patients (17%). In this group of patients, strains of non-fermenting gram-negative bacteria - Pseudomonas aeruginosa (in 6 cases) and Acinetobacter baumannii (in 4 cases), which retained sensitivity to carbapenems in 65% of cases, were most often detected. Conclusions. Non-fermenting gram-negative microorganisms sharply reduce the likelihood of good results of plastic operations. If found in the recipient wound after split-skin grafting signs of an infectious process, it is advisable to use carbapenems.

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Section: цельunclassified

Section: оригинальное исследованиеunclassified

The results of monitoring the dynamics and antibiotic resistance of microflora when performing split-skin grafting in a general surgical hospital

Pavlenko¹,

Кичин²,

Бесчастнов³

2019

VECS

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Outpatient regenerative therapy of a chronic diabetic foot ulcer with exposed bone surface

Pavlova,

Kalsin,

Konoplyannikov

et al. 2024

Journal of Clinical Practice

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Background. One of the unsolved problems of treatment of patients with chronic wounds in outpatient conditions is low efficiency of the used treatment methods, especially it concerns patients with chronic deep wounds and bone tissue involvement in the process. Description of a clinical case. Patient F., 77 years old, came for outpatient treatment in April 2022 with local necrosis in the area of the 1st toe of the left foot. The main diagnosis: atherosclerosis of peripheral vessels of the lower extremities. Multifocal atherosclerosis. Occlusion of the superficial femoral and hamstring arteries, diffuse lesion of the arteries of the lower leg on the left. Chronic arterial insufficiency of the 4th degree. Attempts of revascularisation of the left lower limb. Limited gangrene (Wagner-IV) of the 1st toe of the left foot. Associated diseases: insulin-dependent type 2 diabetes mellitus (more than 30 years of experience). Diabetic polyneuropathy, sensorimotor, pronounced. Diabetic foot syndrome, neurotrophic form. Hypertensive disease 3st. CCN1. Bronchial asthma. Treatment. At the first stage of local treatment we took a wait-and-see tactics during 2 weeks. At the second stage of local treatment we used microsurgical technique of debridement of the affected surface in combination with the method of tiered dressings according to the technology patented by one of the authors. The third stage of treatment consisted of microsurgical treatment of the bone surface in the wound area, combined with the use of autolytic agents, at the same time conditioned medium from human placental mesenchymal stem cell cultures (PB-MSCs) was used in the area of granulation. Complete closure of the open bone fragment was observed after 12 months from the beginning of treatment in outpatient conditions. Conclusion. We have demonstrated the effectiveness of treatment with CS-MSCs for chronic wounds with open bone surfaces in the area of distal parts of the toes of the foot.

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Comparative assessment of wound healing by using a local flap and full-thickness skin graft in reconstructive head and neck surgery

Cited by 2 publications

References 8 publications

The results of monitoring the dynamics and antibiotic resistance of microflora when performing split-skin grafting in a general surgical hospital

The results of monitoring the dynamics and antibiotic resistance of microflora when performing split-skin grafting in a general surgical hospital

Outpatient regenerative therapy of a chronic diabetic foot ulcer with exposed bone surface

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