Comparative Controlled Skin Permeation of Nitroglycerin from Marketed Transdermal Delivery Systems

Chien, Yie W.; Keshary, Prakash R.; Huang, Yih C.; Sarpotdar, Pramod P.

doi:10.1002/jps.2600720837

Cited by 65 publications

(12 citation statements)

References 14 publications

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“…It also allows continuous input of drugs with short biological half-lives and can eliminate pulsed entry into systemic circulation, which often causes undesirable side effects. [9][10][11][12] Technological discoveries, over the last decade, have proven the feasibility of using several methodologies for enhancing transdermal drug delivery. 13 With a diverse set of tools to enhance skin permeability, the future of transdermal drug delivery looks brighter.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: A technical note

2005

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Section: Introductionmentioning

confidence: 99%

Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: A technical note

2005

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“…The in vitro release of propranolol from liquid crystals and MMTS was studied using locally fabricated Franz diffusion type cell1314. A commercial semipermeable membrane was employed in the study as the permeation barrier (Spactrapore, membrane size 5000-7000 molecular weight cut off), thickness 25 μm, (Los Angle, USA).…”

Section: Methodsmentioning

confidence: 99%

Development of mesophasic microreservoir-based transdermal drug delivery system of propranolol

Omray¹,

Kohli²,

Khopade³

et al. 2008

Indian J Pharm Sci

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The mesophasic microreservoir comprises lyotrophic liquid crystals. The liquid crystals were prepared of Brij-35, cetosteryl alcohol and propranolol and evaluated for parameters viz. anisotropy, size and size distribution and drug entrapment efficiency. Subsequent to this liquid crystals based transdermal drug delivery system (TDS) was prepared by incorporating liquid crystals in previously prepared matrix based transdermal patch and evaluated for stability studies like temperature, humidity and aging. The system was also studied for tensile strength, moisture content, water vapor transmission, drug content, anisotropy and In vitro drug release studies.

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“…Soon after sexual intercourse with the subject, his wife reported a severe headache, implying the high permeability of both penile skin and the vaginal mucosa (Talley & Crawley 1985). The rate of release of glyceryl trinitrate from the 'Nitro-Dur' system in vitro is a linear function of the square root of timel a 10cm 2 patch released 40mg in 24 hours (Chien et al 1983). Colfer et al (1982) applied 10 and 20cm 2 systems to the forearm of 10 and 5 subjects, respectively, and reported mean values of Css of 850 ng/L and 1800 ng/L, respectively.…”

Section: 'Nitrodisc'mentioning

confidence: 98%

Pharmacokinetic Considerations in the Use of Newer Transdermal Formulations

Ridout

Santus

Guy

1988

Clinical Pharmacokinetics

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This review addresses the pharmacokinetics and pharmacodynamics of transdermally delivered drugs. The systemic input of drugs via the skin has attracted considerable interest over the past 15 years. The early promise of the administration route has, to some extent, been realised with the approval and successful launching of transdermal formulations of hyoscine (scopolamine), glyceryl trinitrate (nitroglycerin), clonidine and oestradiol. The further application of transdermal delivery, however, will require additional effort. While other molecules (e.g. testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain. These problems are illustrated using information which has been published in the literature. Overall, while the enthusiasm for attraction and benefits of transdermal delivery remain evident, it is clear that future successes will demand a heightened level of commitment and skill from the pharmaceutical scientist.

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Comparative Controlled Skin Permeation of Nitroglycerin from Marketed Transdermal Delivery Systems

Cited by 65 publications

References 14 publications

Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: A technical note

Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: A technical note

Development of mesophasic microreservoir-based transdermal drug delivery system of propranolol

Pharmacokinetic Considerations in the Use of Newer Transdermal Formulations

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