Comparative degree and type of sensitization to common indoor and outdoor allergens in subjects with allergic rhinitis and/or asthma

Abstract

These data show that in our population of subjects with respiratory allergic symptoms, indoor allergen sensitization is strongly associated with asthma, while exclusive sensitization to pollens is associated primarily with rhinitis. Sensitization was more prevalent for indoor allergens than for outdoor allergens in all groups determined according to diagnosis or age. Indices of atopy were higher in men in the group > or = 18 years old. Prevalence and degree of sensitization were shown to peak in young adults, regardless of the allergen, and to diminish with age. This study stresses the role of indoor allergens in the development of asthma and shows the variability of allergic manifestations according to the type of sensitization.

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

“…The role of inhalant allergens in rhinitis and asthma. Aeroallergens are very often implicated in allergic rhinitis and asthma (281)(282)(283). They are usually classified as indoor (principally mites, pets, insects or from plant origin, e.g.…”

Isoallergen Variations Contribute to the Overall Complexity of Effector Cell Degranulation: Effect Mediated through Differentiated IgE Affinity

“…H ouse dust mites (HDMs) rank among the most common allergen sources and cause allergic reactions in .50% of all allergic patients (1). Most individuals allergic to the HDM species Dermatophagoides pteronyssinus (Der p) are sensitized toward the major allergen, Der p 2 (2) which is a 129-aa, 14-kDa, nonglycosylated protein (3,4) with unknown biological function.…”

The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti‐inflammatory therapies

“…Allergic rhinitis often precedes asthma (8). Chronic exposure to allergens, particularly indoors such as animal danders and house dust mites, may lead, through an airway inflammatory and remodeling process, to the development of symptomatic asthma (9,10). Once asthma is established, subsequent allergen exposure may trigger an asthmatic response associated with an increase in airway inflammation.…”