Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats

Ben, Ezekiel E.; Asuquo, Asuquo E.; Owu, Daniel U.

doi:10.9734/ajrb/2019/v4i130058

Cited by 6 publications

(4 citation statements)

References 44 publications

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“…Medicinal plants and natural antioxidants with hypoglycaemic activity are hypothesised as a possible solution due to a plethora of phytochemicals and nonnutritional compounds [31]. Despite the reports on the antioxidant property of T. catappa in diabetic and nondiabetic animal models [32][33][34][35], information on the molecular mode of antioxidant and anti-inflammatory activity of T. catappa in T2DM animal model is lacking. is study evaluates the role of Terminalia catappa aqueous leaf extract in ameliorating hyperglycaemia-induced oxidative stress and inflammation in high-fat diet (HFD)/low-dose streptozotocin-induced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

Iheagwam

Batiha

Ogunlana

et al. 2021

International Journal of Inflammation

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This study aims at evaluating the ameliorative role of Terminalia catappa aqueous leaf extract (TCA) on hyperglycaemia-induced oxidative stress and inflammation in a high-fat, low dose streptozotocin-induced type 2 diabetic rat model. Experimental rats were treated orally with 400 and 800 mg/kg bw TCA daily for four weeks. Antioxidant enzyme activities, plasma glucose concentration, protein concentration, oxidative stress, and inflammation biomarkers were assayed using standard methods. Hepatic relative expressions of tumour necrosis factor-alpha (TNF-α), interleukin-six (IL-6), and nuclear factor-erythroid 2 related factor 2 (Nrf-2) were also assessed. Molecular docking and prediction of major TCA phytoconstituents’ biological activity related to T2DM-induced oxidative stress were evaluated in silico. Induction of diabetes significantly ( p < 0.05 ) reduced superoxide dismutase, glutathione-S-transferase, and peroxidase activities. Glutathione and protein stores were significantly ( p < 0.05 ) depleted, while glucose, MDA, interleukin-six (IL-6), and tumour necrosis factor-α (TNF-α) concentrations were significantly ( p < 0.05 ) increased. A significant ( p < 0.05 ) upregulation of hepatic TNF-α and IL-6 expression and downregulation ( p < 0.05 ) of Nrf-2 expression were observed during diabetes onset. TCA treatment significantly ( p < 0.05 ) modulated systemic diabetic-induced oxidative stress and inflammation, mRNA expression dysregulation, and dysregulated macromolecule metabolism. However, only 800 mg/kg TCA treatment significantly ( p < 0.05 ) downregulated hepatic TNF-α expression. 9-Oxabicyclo[3.3.1]nonane-2,6-diol and 1,2,3-Benzenetriol bound comparably to glibenclamide in Nrf-2, IL-6, and TNF-α binding pockets. They were predicted to be GST A and M substrate, JAK2 expression, ribulose-phosphate 3-epimerase, NADPH peroxidase, and glucose oxidase inhibitors. These results suggest that TCA ameliorates hyperglycaemia-induced oxidative stress and inflammation by activating Nrf-2 gene.

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Section: Introductionmentioning

confidence: 99%

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

Iheagwam

Batiha

Ogunlana

et al. 2021

International Journal of Inflammation

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“…As research into the natural agent progresses, medicinal plants have shown the ability to synthesize numerous chemical compounds that are essential in healthcare as therapeutic remedies hence serving as alternative source to conventional drugs. Recent studies have shown that the leaf extract of Terminalia catappa possesses anti-inflammatory effects [23,24] in addition to other usefulness earlier reported. Terminalia catappa is a tropical tress of the combretaceae family whose leaves and barks are often used because of its diaphoretic, anti-ingestion, hepatoprotective effect [25,26], nephroprotective effect [27] and anti-tumor effect [28].…”

Section: Introductionmentioning

confidence: 91%

Possible amelioration of oxidative stress damage via cyclo-oxygenase pathway by aqueous extract of Terminalia catappa leaves in alloxan induced diabetic rats

Ben¹,

Asuquo²,

Owu³

2021

GSC Biol. and Pharm. Sci.

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Cellular damage due to oxidative stress had been implicated in the pathogenesis of many diseases including diabetes mellitus. This study was to investigate possible amelioration of oxidative stress in diabetes mellitus by aqueous leaf extract of Terminalia catappa. Wistar rats weighing 200 -250g was divided into nine groups with 6 rats per group. The main test group has 5 groups while the group for assessing possible mechanism had 4 groups. Group 1 (control) and group 2(non-diabetic) received orally per kg body weight; 0.5ml distilled water and 130mg of Terminalia catappa respectively. Group 3 (diabetic), group 4 (diabetic + extract) and group 5 (diabetic + insulin) also respectively received 0.5ml distilled water, 130mg Terminalia. catappa extract and 0.75UI insulin subcutaneously. Groups 6, 7, 8 and 9 administered orally with aspirin; 30mg/kg, meloxicam; 2mg/kg and combination of extract with aspirin and meloxicam respectively. The experiment lasted for 14 days and glucose level ≥ 200mg/dl was considered diabetic following intraperitoneal injection of 150mg/kg body weight of alloxan. Results showed significant (p<0.05) increase in serum low density lipoprotein cholesterol (LDL-c), malondialdehyde (MDA) and a significant (p<0.05) decrease in superoxide dismutase (SOD) in diabetic group compared with control. The LDL and MDA were significantly (p<0.05) reduced while SOD increased significantly (p<0.05) when compared with diabetic group and the control following administration of Terminalia catappa, aspirin, meloxicam and insulin. The leaf extract of Terminalia catappa possess possible ameliorating potential on oxidative stress induced damages by impeding lipid peroxidation but improved on antioxidant enzyme in diabetic condition.

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“…Pada penelitian yang dilakukan terhadap subyek tikus Wistar yang diinduksi diabetes yaitu dengan mengukur penanda inflamasi pada DM tipe-2 yang diberikan perlakuan menggunakan ekstrak ketapang dengan berbagai variasi dosis (mg/kg BB) 130, 400, dan 800 yaitu dengan mengukur kadar sitokin IL-6 didapatkan penurunan yang signifikan (p<0,05) (Ben et al 2019b;. Ben et al (2019a) menyatakan bahwa tingkat IL-6 berkurang secara signifikan dalam kelompok tikus DM tipe-2 yang diobati dengan ekstrak ketapang dosis 130 mg/kg BB selama 14 hari.…”

Section: Efek Pemberian Variasi Ekstrak Pegagan Dan Ketapang Terhadap...unclassified

Pengaruh Pemberian Ekstrak Pegagan (Centella asiatica) dan Ketapang (Terminalia catappa) terhadap Kadar Interleukin-6 pada Diabetes Melitus Tipe-2

Pratiwi¹,

Shafriani²

2022

JECP

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Diabetes Melitus Tipe-2 (DM tipe-2) merupakan penyakit metabolik dengan karakteristik hiperglikemia yang terjadi akibat rendahnya sekresi insulin atau kerja insulin yang dihasilkan oleh sel beta pankreas, serta terjadinya gangguan metabolisme karbohidrat, lipid, dan protein. Hiperglikemia akan menyebabkan terjadinya inflamasi pada DM tipe-2 yang ditandai dengan peningkatan kadar sitokin proinflamasi seperti IL-6, sehingga diperlukan adanya alternatif pengobatan yang dapat menekan respon imun tersebut seperti pemanfaatan tanaman (Terminalia catappa) dan (Centella asiatica) yang berpotensi sebagai anti-oksidan dan anti-inflamasi. Penelitian ini bertujuan mengetahui pengaruh pemberian ekstrak Terminalia catappa dan Centella asiatica terhadap kadar IL-6 pada DM tipe-2. Metode penelitian ini menggunakan Literature review dengan melakukan pencarian artikel pada database Google Scholar, dan science direct dengan metode PICO yang dipublikasikan pada tahun 2011-2021. Hasil penelusuran literatur diperoleh 10 artikel yang sesuai. Artikel-artikel tersebut terdiri dari 5 artikel dengan pemberian ekstrak Terminalia catappa dan 5 artikel dengan pemberian ekstrak Centella asiatica pada DM tipe-2. Pada kelompok DM tipe-2 dengan perlakuan pemberian ekstrak Terminalia catappa atau pemberian ekstrak Centella asiatica, ditemukan kadar IL-6 dan kadar glukosa darah lebih rendah daripada kelompok tanpa perlakuan pemberian ekstrak. Variasi penambahan dosis ekstrak Terminalia catappa atau Centella asiatica berpengaruh terhadap penurunan kadar glukosa dan IL-6 pada DM tipe-2. Adanya pengaruh berupa variasi penambahan dosis ekstrak Terminalia catappa dan ekstrak Centella asiatica terhadap penurunan kadar IL-6 dapat menjadi imunomodulator dalam penekanan sel imun pada DM tipe-2 agar tidak terjadi inflamasi.

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Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats

Cited by 6 publications

References 44 publications

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

Possible amelioration of oxidative stress damage via cyclo-oxygenase pathway by aqueous extract of Terminalia catappa leaves in alloxan induced diabetic rats

Pengaruh Pemberian Ekstrak Pegagan (Centella asiatica) dan Ketapang (Terminalia catappa) terhadap Kadar Interleukin-6 pada Diabetes Melitus Tipe-2

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