Comparative Effects of Tetragastrin and Histamine on Acid and Intrinsic Factor Secretion in Man

Abstract

KBSTER, K. H., R0DBR0, PAUL & PETERSEN, H. J. Comparative Effects of Tetragastrin and Histamine on Acid and Intrinsic Factor Secretion in Man. Scand. J . Gasfroenf. 3,[23][24][25][26][27][28][29][30][31][32][33][34][35] 1967. The N-Carbobenzyloxy(=Cbo)-C-terminal tetrapeptide sequence of gastrin has been synthesized, and this ferrugasfrin has been compared with histamine with respect to acid and intrinsic factor secretion. Fiftytwo patients with various gastric disorders were examined, and both stimulants were given as subcutaneous injections. Tetragastrin in doses of 5 to 10 pg/kg elicits a gastric acid secretion of the same pattern and magnitude as is found after histamine, 40 pg/kg. By doubling the dose of tetragastrin no further acid secretion was Scand J Gastroenterol Downloaded from informahealthcare.com by Mcgill University on 12/13/14 For personal use only. Scand J Gastroenterol Downloaded from informahealthcare.com by Mcgill University on 12/13/14 For personal use only. Scand J Gastroenterol Downloaded from informahealthcare.com by Mcgill University on 12/13/14 For personal use only.

Factors affecting maximal acid secretion

“…The MAO observed with any one stimulus, (Table 2), is comparable with that observed with any other stimulus but the values are not identical (Ward et al, 1963;Makhlouf et al, 1965;Hubel, 1966;Koster et al, 1968).…”

“…Nature of the stimulus At present, histamine (Kay, 1953), histalog (Rosiere & Grossman, 1951), gastrin (Makhlouf, MacManus & Card, 1964b), pentagastrin (Makhlouf et al, 1966) or tetragastrin (Koster, Rodbro & Peterson, 1968) are used to judge the PCM while crystalline insulin (Hollander, 1946) or 2-deoxy-Dglucose (an analogue of glucose) are administered intravenously to judge vagal continuity (Duke, Hirschowitz & Sachs, 1965;Thomas & Duthie, 1968). The MAO observed with any one stimulus, (Table 2), is comparable with that observed with any other stimulus but the values are not identical (Ward et al, 1963;Makhlouf et al, 1965;Hubel, 1966;Koster et al, 1968).…”

Review article: methods of measuring gastric acid secretion

“…19,27 A further gastric stimulant used in gastric acid measurement studies is Gastrin Releasing Peptide (GRP). 28,29 GRP is a neuropeptide, which stimulates the G cells in the antrum to secrete gastrin, which in turn stimulates gastric acid secretion.…”

Pentagastrin as a Stimulant in Routine Clinical Testing of Gastric Acid Secretion

“…Certain practical considera tions necessitate, however, that one single stim ulant m ust be chosen; the preferred choice would be gastrin itself, but the price is prohibitive for use in routine exam inations. As regards tetragastrin, the initial trials seem to be promising but there are so far such a limited number th at detailed evaluation is not possible [4,7,10]. In using histamine together with an antihistam ine, the frequency of side effects will be considerably higher than with any of the other stim ulants.…”

“…For m any years the augm ented histamine test has been the pre ferred method for estim ating the m aximal gastric acid secretion, and there is no theoretical advantage in using gastrin or the synthetic peptides tetragastrin [10] and pentagastrin. Comparison of the stim ulants referred to above reveals only minor differences in their capacity to stim ulate the gastric glands.…”