Comparative Efficacy of Anti IL-4, IL-5 and IL-13 Drugs for Treatment of Eosinophilic Asthma: A Network Meta-analysis

Iftikhar, Imran H.; Schimmel, M.E.; Bender, William; Swenson, Colin; Amrol, David J.

doi:10.1007/s00408-018-0151-5

Cited by 48 publications

(23 citation statements)

References 48 publications

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“…Activation of IL‐4 is also significant in enhancing IgG1 and IgE generation in asthma (Barnes, 2008). During the asthma process, IL‐5 is capable of controlling eosinophil formation and proliferation, IgE secretion in asthma elicited by IL‐4 can also be enhanced by IL‐5 (Iftikhar, Schimmel, Bender, Swenson, & Amrol, 2018). As a classic inflammatory cytokine, IL‐6 promotes IL‐4 generation and modulates the Th1/Th2 balance toward Th2, thus enhancing Th2 differentiation and reducing Th1 cell differentiation (Dienze & Rincon, 2009).…”

Section: Discussionmentioning

confidence: 99%

Rubusoside alleviates the ovalbumin‐induced mice allergic asthma by modulating the NF‐κB activation

et al. 2020

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The anti‐inflammatory and anti‐asthmatic effects of rubusoside (Rbs) were investigated in the ovalbumin (OVA)‐induced asthmatic mice, followed by effective attenuation of Rbs treatment on the airway hyperresponsiveness and reduction of inflammatory cells inside the bronchoalveolar lavage fluid (BALF). The mitigation of inflammatory infiltration as a result of Rbs treatment was histologically observed in these mice lungs. Rbs contributed to the decrease of inflammatory cytokines (TNF‐α, IL‐13, IL‐6, IL‐5, and IL‐4) inside the BALF of mice with asthma. A decline of OVA‐dependent IgE and IgG1 inside the serum was also noticed in these mice. Rbs was proved to enhance the mRNA level of Foxp3 inside the mice lung affected with asthma while decrease that of IL‐17A, IL‐23, and RORγt. NF‐κB pathway activation elicited by OVA was suppressed by Rbs inside the pulmonary tissues. Rbs played significantly in the reduction of airway inflammation induced by OVA which with modulating NF‐κB pathway activation. Practical applications Simultaneous therapy with medicine and food is strategically significant for disease prevention and treatment in traditional Chinese medicine. Rbs is a diterpene glycoside isolated from Rubus suavissimus. The anti‐inflammatory and anti‐asthmatic mechanism dependent of Rbs need further study clinically. The goal of current investigation is to explore the anti‐inflammatory as well as anti‐asthmatic activity of Rbs in mouse models of OVA‐induced experimental allergic asthma. Results of the present study are scientifically supportive for the use of Rbs as an adjunctive reagent for clinical treatment of allergic asthma.

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Section: Discussionmentioning

confidence: 99%

Rubusoside alleviates the ovalbumin‐induced mice allergic asthma by modulating the NF‐κB activation

et al. 2020

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“…Among these Th2 cytokines, IL-4 promotes the differentiation, proliferation, and activation of B cells; induces inflammatory cells eosinophils to infiltrate into the lung tissue; and increases the levels of IgE and IgG1 in serum (Barnes, 2008). IL-5 can control the formation and proliferation of eosinophils and enhances the IL-4-induced IgE secretion during asthma (Iftikhar, Schimmel, Bender, Swenson, & Amrol, 2018). In addition, IL-13 promotes the differentiation of B cells and directly induces an inflammatory reaction and AHR in the lungs of asthmatic mice (Karo-Atar, Bitton, Benhar, & Munitz, 2018;Lightwood et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Protective activity of mogroside V against ovalbumin‐induced experimental allergic asthma in Kunming mice

et al. 2019

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We investigated the antiasthmatic effect of mogroside V (Mog V) in mice with ovalbumin (OVA)‐induced asthma. Administration of Mog V effectively attenuated OVA‐induced airway hyperresponsiveness and reduced the number of inflammatory cells in bronchoalveolar lavage fluid (BALF). Histological examination showed that Mog V reduced the inflammatory infiltration of the lungs in the asthmatic mice. ELISAs suggested that Mog V effectively decreased the levels of IL‐4, IL‐5, and IL‐13 in BALF and serum levels of OVA‐specific IgE and IgG1 in the asthmatic mice. A quantitative reverse‐transcription PCR assay also indicated that Mog V decreased the mRNA levels of IL‐17A, IL‐23, and RORγt in the lungs of the asthmatic mice (the opposite effect on Foxp3 mRNA). Furthermore, Mog V significantly reduced the OVA‐induced activation of NF‐κB in the lungs. This study indicates that Mog V alleviates OVA‐induced inflammation in airways, and this effect is associated with a reduction in NF‐κB activation. Practical applications A traditional Chinese medicine herb has been reported to have a strong curative effect on asthma in clinical practice. Siraitia grosvenorii is known in China as a functional food product with the ability to improve lung function. Mogroside V is a triterpene glycoside isolated from S. grosvenorii. Nonetheless, the antiasthmatic effect of mogroside V has not been evaluated yet. The aim of this study was to investigate the antiasthmatic activity of mogroside V in mice with chemically induced asthma. The data from this study will provide some scientific evidence supporting wider use of S. grosvenorii in functional foods.

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“…Quality of life scores were improved but not to a clinically significant extent. No head‐to‐head trials have been reported; indirect comparisons have produced different conclusions about relative efficacy …”

Section: Efficacy Of Monoclonal Antibodies For Asthmamentioning

confidence: 99%

Monoclonal antibodies for the treatment of severe asthma

Chaplin¹

2020

Prescriber

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Comparative Efficacy of Anti IL-4, IL-5 and IL-13 Drugs for Treatment of Eosinophilic Asthma: A Network Meta-analysis

Abstract: All drugs except for tralokinumab showed improvements in FEV, ACQ, and AQLQ. Only reslizumab and dupilumab were associated with statistically significant reductions in asthma exacerbation rates.

Cited by 48 publications

References 48 publications

Rubusoside alleviates the ovalbumin‐induced mice allergic asthma by modulating the NF‐κB activation

Rubusoside alleviates the ovalbumin‐induced mice allergic asthma by modulating the NF‐κB activation

Protective activity of mogroside V against ovalbumin‐induced experimental allergic asthma in Kunming mice

Monoclonal antibodies for the treatment of severe asthma

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