Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta‐Analysis of Randomized Controlled Trials

Duan, Xiaojiao; Wu, Jiarui; Huang, Xingyue; Wang, Kaihuan; Zhao, Yi; Zhang, Dan; Liu, Xinkui; Zhang, Xiaomeng

doi:10.1155/2018/7942936

Cited by 8 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It seriously affects the quality of participants’ life and causes serious economic burden. [ 20 ] It is necessary to provide a simple, safe, effective, and compliant pulmonary rehabilitation method for AECOPD participants with NIV. Under the guidance of the theory of TCM, sitting and lying Liuzijue is to adjust and control the rise and fall of breath in the body through the specific 6-word vomiting training of “xu,” “he,” “hu,” “si,” “chui,” and “xi.” Thus improve the viscera functions of the human body, such as liver, heart, spleen, lung, kidney, Sanjiao, and maintain the balance of the whole body.…”

Section: Discussionmentioning

confidence: 99%

Effect of sitting and lying Liuzijue for lung rehabilitation in acute exacerbation of chronic obstructive pulmonary disease patients with non-invasive ventilation

Jing

Wang²,

Yue

et al. 2020

Medicine

View full text Add to dashboard Cite

Introduction: Chronic obstructive pulmonary disease (COPD) is a lung disease with the highest incidence and high mortality in the world. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) can significantly accelerate the progression of the disease. Pulmonary rehabilitation is one of the effective treatment methods in COPD patients, but few studies have focused on the effect of pulmonary rehabilitation in AECOPD patients. Liuzijue can improve the pulmonary function and relieve symptoms of COPD patients. However, due to the influence of disease and non-invasive ventilation (NIV), AECOPD patients have poor compliance with getting out of bed at the early stage. Sitting and lying Liuzijue is more suitable in AECOPD patients with NIV. Therefore, this study will evaluate the effect of sitting and lying Liuzijue for lung function, exercise endurance, and quality of life in AEOPD patients with NIV. Methods: This study is a clinical randomized controlled trial. Sixty four AECOPD patients with NIV will be randomly divided into the experimental group and the control group. All participants will be treated with routine treatment and nursing according to their specific condition. The experimental group will be combined with sitting and lying Liuzijue on the basis of the control group. The duration of the exercise will be 3 months. The primary outcomes are the pulmonary function test and 6-minute walking test (6MWT). The secondary outcome measures include blood gas parameters, dyspnea index (the Modified Medical Research Council Dyspnea Scale [mMRC]), the body-mass, airflow obstruction, dyspnea and exercise capacity (BODE) index, anxiety, and depression (Hospital Anxiety and Depression Scale [HADS]), and quality of life (St·George Respiratory Questionnaire [SGRQ]). The measurement of outcomes will be evaluated at week 13. Discussion: It's imperative to focus on pulmonary rehabilitation in AECOPD patients. The purpose of this study is to evaluate the effect of sitting and lying Liuzijue for pulmonary rehabilitation in AECOPD patients with NIV. Trial registration: ChiCTR2000034530, Registered on July 8th, 2020.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of sitting and lying Liuzijue for lung rehabilitation in acute exacerbation of chronic obstructive pulmonary disease patients with non-invasive ventilation

Jing

Wang²,

Yue

et al. 2020

Medicine

View full text Add to dashboard Cite

show abstract

“…Outcomes: the rates of clinical efficacy (RCE), clinical symptom disappearance time (antipyretic time, cough disappearance time, lung rale disappearance time, lung shadow disappearance time, and asthma disappearance time), hospitalization time, and adverse drug reactions/adverse drug events (ADRs/ADEs). e RCE = (the total number of patients − the number of patients ineffective)/the total number of patients * 100% [14][15][16]. e efficacy evaluation criteria were based on the recovery of clinical symptoms and physiological indicators after treatment, wherein if the clinical symptoms and physiological indicators after treatment were changeless or deteriorate, it was judged to be invalid.…”

Section: Eligibility Criteria and Exclusion Criteriamentioning

confidence: 99%

Comparative Efficacy of Chinese Herbal Injections for Treating Pediatric Bronchopneumonia: A Bayesian Network Meta‐Analysis of Randomized Controlled Trials

Duan

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Introduction. Pediatric bronchopneumonia is one of the common respiratory diseases in pediatrics. Chinese herbal injections (CHIs) are widely used to treat pediatric bronchopneumonia. In this study, we examined the efficacy of CHIs in the treatment of pediatric bronchopneumonia using a network meta-analysis (NMA). Methods. Randomized controlled trials (RCTs) of CHIs combined western medicine (WM) versus WM were searched from electronic databases. WinBUGS 1.4.3 and Stata 13.0 were adopted to compute calculations and prepare graphs, respectively. Results. 168 RCTs with 21917 patients were included. The results revealed that Xixinnao injection (XXN) + WM had the most probability to be the best intervention in the four aspects of rate of clinical efficacy, antipyretic time, cough disappearance time, and lung shadow disappearance time. While as to lung shadow disappearance time, asthma disappearance time, and hospitalization time, Yanhuning injection (YHN) + WM could be the best intervention. The safety of CHIs needs to be further assessed. Conclusions. Based on this NMA, XXN + WM and YHN + WM were potential optimal therapies in pediatric bronchopneumonia, and their safety should be strictly monitored.

show abstract

“…The theory of TCM holds that “zheng qi deficiency” is one of the main factors involved in ACI; therefore, an approach of “supporting zheng qi and protecting the brain” allows the treatment of ACI to be broadened. Traditional Chinese medicine injections (TCMIs) are widely used to treat diseases [ 9 – 12 ] and possess characteristics of fast efficacy and high bioavailability [ 13 – 15 ]. In combination, TCMIs and Western medicine (WM) have become a supportive method for disease treatment in China [ 16 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Tonic Traditional Chinese Medicine Injection on Acute Cerebral Infarction: A Bayesian Network Meta‐Analysis

Zhou

Xie

Wang³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Western medicine (WM) has certain limitations in terms of treating acute cerebral infarction (ACI), while tonic traditional Chinese medicine injections (TCMIs) have been shown to have obvious clinical effects as an adjunct to WM for ACI. However, most randomized controlled trials (RCTs) to date have not performed direct comparisons of efficacy among tonic TCMIs. This study designed a Bayesian network meta-analysis (NMA) to explore the therapeutic effect of tonic TCMIs on ACI. A comprehensive search of RCTs of TCMIs combined with WM for ACI was conducted using electronic databases for studies dated from the start date of each database until February 2020. Stata 13.0 and ADDIS 1.16.7 software were used to plot and analyze the data. Sixty-six RCTs with a total of 5,989 patients involving 7 kinds of tonic TCMIs were included. Among TCMIs, Shenfu injection (SFI) + WM ranked first in terms of improving clinical efficacy and the activities of daily living (ADLs) rating and reducing interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels. While Ciwujia injection (CI) + WM was the best choice for reducing neurological impairment and the high-cut viscosity of whole blood (HCV). Shenmai injection (SI) + WM had the greatest effects in terms of decreasing the levels of low-cut viscosity of whole blood (LCV), fibrinogen (FIB), and plasma viscosity (PV). Based on the cluster analysis of the clinical efficacy and the neurological impairment, CI + WM and Shenqifuzheng (SQI) + WM were the best options for treating ACI. With respect to adverse drug reactions (ADRs), 35 RCTs did not monitor ADRs during treatment. In conclusion, tonic TCMIs could assist WM in benefiting patients with ACI. However, due to the limitations of the current study, strict monitoring of ADRs and data from high-quality RCTs will be required in future to verify the advantage of TCMIs.

show abstract

Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta‐Analysis of Randomized Controlled Trials

Cited by 8 publications

References 20 publications

Effect of sitting and lying Liuzijue for lung rehabilitation in acute exacerbation of chronic obstructive pulmonary disease patients with non-invasive ventilation

Effect of sitting and lying Liuzijue for lung rehabilitation in acute exacerbation of chronic obstructive pulmonary disease patients with non-invasive ventilation

Comparative Efficacy of Chinese Herbal Injections for Treating Pediatric Bronchopneumonia: A Bayesian Network Meta‐Analysis of Randomized Controlled Trials

Clinical Efficacy of Tonic Traditional Chinese Medicine Injection on Acute Cerebral Infarction: A Bayesian Network Meta‐Analysis

Contact Info

Product

Resources

About