Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma

Sarkar, Rashmi; Garg, Vijay Kumar; Bansal, Shivani; Sethi, Sumit; Gupta, Chitra

doi:10.1097/dss.0000000000000642

Cited by 64 publications

(66 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The large molecular weight of mandelic acid may produce a more uniform effect due to greater skin retention and slower penetration of the strateum corneum. It is also generally well tolerated by sensitive skin 18,20 and no patients in our study reported any degree of skin irritation.…”

Section: Discussionmentioning

confidence: 60%

See 1 more Smart Citation

Effects of Topical Mandelic Acid Treatment on Facial Skin Viscoelasticity

Jacobs

Culbertson

2018

Facial plast Surg

View full text Add to dashboard Cite

Mandelic acid is an α-hydroxy acid with reported benefit in treating acne and hyperpigmentation. The authors have developed a topical mandelic acid formulation that subjectively improves the quality of aged skin. Although the gold standard for assessing outcomes, photographic documentation is limited by subjective interpretation. Tools for measuring physical skin properties allow for an objective assessment of changes in skin quality. The authors sought to objectively study the viscoelastic changes to the skin following treatment with topical mandelic acid, using the Cutometer MPA 580. Twenty-four patients, twenty females and four males, aged 42 to 68 years, were studied over a four-week period. Mandelic acid was applied topically to the face twice a day for four weeks. The lower eyelid skin viscoelastic properties were assessed weekly using the Cutometer. After four weeks of topical mandelic acid treatment, the elasticity of lower eyelid skin increased 25.4% (P = .003). Skin firmness increased 23.8% (P = .029). Improvement in photographic appearance correlated with these findings. Mandelic acid is another topical treatment option for improving skin quality, and is well tolerated by patients. The authors feel that the Cutometer or similar device should be used routinely in facial plastic surgery to objectively assess outcomes of various treatment modalities.

show abstract

Section: Discussionmentioning

confidence: 60%

“…Most literature suggests its use for the treatment of acne or hyperpigmentation. [18][19][20] It is of interest to note that the ancient Egyptians first used a form of a mandelic acid compound to improve the aging effects on facial skin, 3,600 years ago. 21 Our interest was to elucidate its possible effects on the physical properties of the skin.…”

mentioning

confidence: 99%

Effects of Topical Mandelic Acid Treatment on Facial Skin Viscoelasticity

Jacobs

Culbertson

2018

Facial plast Surg

View full text Add to dashboard Cite

show abstract

“…The scale consists of 10 questions pertaining to the quality of life and impact of the disease rated on a Likert scale. Other psychometric scales that can be used in those with melasma are the Dermatology Life Quality Index (DLQI) and the SKINDEX-16 [ 42 – 46 ].…”

Section: Introductionmentioning

confidence: 99%

Melasma: an Up-to-Date Comprehensive Review

Ogbechie-Godec

Elbuluk

2017

Dermatol Ther (Heidelb)

254

210

View full text Add to dashboard Cite

Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1–50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates. Various topical, oral, and procedural therapies have been successfully used to treat melasma. Traditional topical therapies including hydroquinone, tretinoin, corticosteroids, and triple combination creams; however, other synthetic and natural topical compounds have also shown varying efficacies. Promising oral therapies for melasma include tranexamic acid, Polypodium leucotomos, and glutathione. Procedures, including chemical peels, microneedling, radiofrequency, and lasers, are also often used as primary or adjunctive treatments for melasma. Notably, combination therapies within or across treatment modalities generally result in better efficacies than monotherapies. This review serves as a comprehensive update on the current understanding of the epidemiology, pathogenesis, clinical and histologic features of melasma, as well as treatments for this common, yet therapeutically challenging, condition.

show abstract

“…Alpha hydroxy acids (AHAs), including glycolic acid (GA) and citric acid, are naturally occurring organic acids commonly present in foods. GA has been established as a safe, nontoxic substance in fruits and participates in multiple bioactivities such as inducing antioxidant activity, increasing the effects of melasma treatment, and biosynthesizing ceramide [1,2]. GA was initially used to treat disorders of keratinization [3], and was used for increasing the production of dermal and epidermal glycosaminoglycans to prevent both dermal and epidermal atrophy resulting from longterm topical corticosteroid use [4].…”

Section: Introductionmentioning

confidence: 99%