Comparative evaluation of fish oil and butter oil in modulating delivery of galantamine hydrobromide to brain via intranasal route: pharmacokinetic and oxidative stress studies

Katdare, Aakash; Khunt, Dignesh; Thakkar, Shreya; Polaka, Surya Narayana; Misra, Manju

doi:10.1007/s13346-020-00739-y

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…Similar to the results described above, the evolution of the burst keywords during the past decade shows that the research focus has experienced a transition from the study of pathways and mechanisms of intranasal delivery to the study of intranasal drug delivery for CNS disorders and nasal drug delivery systems. On top of that, it is interesting to note that the burst of five keywords including “oxidative stress (2015–2020)” ( Farfán et al, 2020 ; Katdare et al, 2020 ), “drug delivery (2017–2020) ( Zhuang et al, 2011 ; Haney et al, 2015 ),” “neuroinflammation (2017–2020) ( Rhea et al, 2020 ),” “nanostructured lipid carrier (2018–2020) ( Agbo et al, 2021 ),” and “formulation (2018–2020) ( Bors et al, 2020 ; Pires et al, 2020 )” is still ongoing, suggesting that these research topics have gained great attention in recent years and also have great potential to continue to be the research focus and frontiers in the near future. Therefore, we can expect to see future work dissecting these topics, leading to more interesting scientific discoveries.…”

Section: Resultsmentioning

confidence: 99%

Current State and Future Directions of Intranasal Delivery Route for Central Nervous System Disorders: A Scientometric and Visualization Analysis

Zhou

Wang

et al. 2021

Front. Pharmacol.

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Background: The management of various central nervous system (CNS) disorders has been challenging, due to highly compact blood-brain barrier (BBB) impedes the access of most pharmacological agents to the brain. Among multiple strategies proposed to circumvent this challenge, intranasal delivery route has sparked great interest for brain targeting in the past decades. The aim of this study was to apply scientometric method to estimate the current status and future trends of the field from a holistic perspective.Methods: All relevant publications during 1998–2020 were retrieved from the Web of Science Core Collection (SCIE, 1998-present). Two different scientometric software including VOS viewer and CiteSpace, and one online platform were used to conduct co-authorship, co-citation, and co-occurrence analysis of journals, countries, institutes, authors, references and keywords.Results: A total of 2,928 documents, including 2,456 original articles and 472 reviews, were retrieved. Our analysis revealed a significant increasing trend in the total number of scientific publications over the past 2 decades (R2 = 0.98). The United States dominated the field, reflecting in the largest amount of publications (971), the highest H-index (99), and extensive international collaboration. Jamia Hamdard contributed to most publications. Frey WH and Illum L were key researchers with the highest number of publications and citations, respectively. The International Journal of Pharmaceutics was the most influential academic journal, and Pharmacology/Pharmacy and Neurosciences/Neurology were the hottest research categories in this field. Based on keywords occurrence analysis, four main topics were identified, and the current research focus of this field has shifted from cluster 4 (pathways and mechanisms of intranasal delivery) to cluster 2 (the study of nasal drug delivery systems), especially the nanostructured and nano-sized carrier systems. Keywords burst detection revealed that the research focus on oxidative stress, drug delivery, neuroinflammation, nanostructured lipid carrier, and formulation deserves our continued attention.Conclusion: To the authors’ knowledge, this is the first scientometric analysis regarding intranasal delivery research. This study has demonstrated a comprehensive knowledge map, development landscape and future directions of intranasal delivery research, which provides a practical and valuable reference for scholars and policymakers in this field.

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Section: Resultsmentioning

confidence: 99%

Current State and Future Directions of Intranasal Delivery Route for Central Nervous System Disorders: A Scientometric and Visualization Analysis

Zhou

Wang

et al. 2021

Front. Pharmacol.

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“…Therefore, incorporating HAS into liposomes will also potentially enable HAS to a better therapeutic effect on AD. [26][27][28] In the preparation of HAS into HAS-LPs, the film dispersion method was chosen and the encapsulation rate was used as a measurement target, which fully considered the lipid solubility of HAS and ensured that was it completely miscible with the lipid material and trichloromethane. In 196 the subsequent process, ultrasonic hydration of the dispersed liposomes reduced the particle size of the formulation and improved the hydration efficiency.…”

Section: Discussionmentioning

confidence: 99%

Development and in vivo Evaluation of Hydroxy-α-Sanshool Intranasal Liposomes as a Potential Remedial Treatment for Alzheimer’s Disease

Li¹,

Feng²,

Sun³

et al. 2022

IJN

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Hydroxy-α-sanshool (HAS) improves cognitive dysfunction, but its structural instability has limited its clinical application. The present study was conducted to investigate the optimal formulation of hydroxy-α-sanshool liposomes (HAS-LPs) and its effect on ameliorating learning and memory disorders in an Alzheimer's disease (AD) model. Methods: In this study, HAS was prepared as HAS-LP using a thin film dispersion method. After selecting the optimal preparation conditions, HAS-LP was characterized using transmission electron microscopy (TEM) and by measuring the zeta potential, particle size, and in vitro drug release. Next, evaluated the effect of HAS-LP on the rat nasal mucosa and then applied it to AD mice. By performing behaviour experiments, pathological test and related pharmacokinetic parameters, we explored its effect on attenuating learning and memory impairment in mice. Results: When the mass ratio of HAS:cholesterol:soybean lecithin was 1:4:16 and 15 mL of ultrapure water were added, the highest encapsulation efficiency and drug loading were obtained. HAS-LP had a particle size of 181.77 nm, a polydispersity index of 0.207 and a zeta potential of −53.8 mV, and it remained stable at 25 °C for 1 week and 4 °C for 8 weeks. Moreover, HAS-LP exhibited slow drug release and was highly consistent with the Higuchi release model. HAS-LP was not significantly toxic to the nasal mucosa and effectively alleviated D-galactose-induced learning memory deficits and protected mouse hippocampal neuronal cells. HAS-LP was highly enriched in plasma and brain tissue after administration via the nasal route and obtained some ability to target the brain. Conclusion: HAS encapsulated in soybean lecithin and cholesterol was successfully developed, suggesting that treatment with the nanoparticles might reverse some AD symptoms. Therefore, these nanoparticles might be used as promising new candidates for the delivery of HAS to treat AD.

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“…However, further investigations are necessary to gain better insight into the most efficient methods to utilize the potential of nose-to-brain pathways. The presented studies usually do not evaluate the effects of different oils, surfactants and co-surfactants on pharmacokinetic parameters of the analyzed formulations, except for the studies focusing on butter and fish oils as potential permeation enhancers [138,139,169]. The mentioned studies show that the modifications in microemulsion composition can significantly change the permeability of nasal mucosa which may well affect the therapeutic efficacy of the applied formulation.…”

Section: Discussionmentioning

confidence: 99%

“…As a continuation of the previous research, Katdare et al [138] prepared and evaluated similar formulations with galantamine hydrochloride, a reversible and competitive cholinesterase inhibitor. The microemulsion was composed of Capmul ® MCM EP (oil), Tween ® 80 (surfactant), Transcutol ® P (co-surfactant), and water.…”

Section: Neurodegenerative Disordersmentioning

confidence: 96%

Microemulsion-Based Media in Nose-to-Brain Drug Delivery

et al. 2021

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Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to other delivery routes, including the most popular oral one. Due to the unique anatomical features of the nasal cavity, drugs administered intranasally can be delivered directly to the central nervous system. The most important advantage of this approach is the ability to avoid the blood–brain barrier surrounding the brain and blocking the entry of exogenous substances to the central nervous system. Moreover, selective brain targeting could possibly avoid peripheral side effects of pharmacotherapy. The challenges associated with nose-to-brain drug delivery are mostly due to the small volume of the nasal cavity and insufficient drug absorption from nasal mucosa. These issues could be minimized by using a properly designed drug carrier. Microemulsions as potential drug delivery systems offer good solubilizing properties and the ability to enhance drug permeation through biological membranes. The aim of this review is to summarize the current status of the research focused on microemulsion-based systems for nose-to-brain delivery with special attention to the most extensively investigated neurological and psychiatric conditions, such as neurodegenerative diseases, epilepsy, and schizophrenia.

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Comparative evaluation of fish oil and butter oil in modulating delivery of galantamine hydrobromide to brain via intranasal route: pharmacokinetic and oxidative stress studies

Cited by 12 publications

References 28 publications

Current State and Future Directions of Intranasal Delivery Route for Central Nervous System Disorders: A Scientometric and Visualization Analysis

Current State and Future Directions of Intranasal Delivery Route for Central Nervous System Disorders: A Scientometric and Visualization Analysis

Development and in vivo Evaluation of Hydroxy-α-Sanshool Intranasal Liposomes as a Potential Remedial Treatment for Alzheimer’s Disease

Microemulsion-Based Media in Nose-to-Brain Drug Delivery

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