Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas

Abstract

Summary. Aim: To study the state of purine metabolism in gastric (GAC) and pulmonary (PAC) adenocarcinomas and to assess its clinical and pathogenetic significance. Patients and Methods: One hundred and six male patients were examined, among whom were 63 subjects aged 34 to 79 suffering from GAC, and 43 subjects aged 24 to 76 suffering from PAC. In GAC, the ratio of the pyloric, corporeal and antral localization of the tumor and variant of overall gastric lesion accounted to 24:5:1:1; and that of the central and peripheral PAC was 2:1. Serum levels of purine metabolism products (uric acid, oxypurinol, adenine, guanine, xanthine, hypoxanthine) were measured and activities of xanthine oxidase, xanthine deaminase, adenosine deaminase and 5-nucleotidase were analyzed. Results: Purine metabolism disorders are observed in all GAC and 91% of PAC patients; among other things, hyperuricemia is observed in ¾ and ½ of cases, respectively; moreover, the nature of changes is more pronounced in gastric cancer and, in both groups of patients, these indices reflect the disease course severity, are associated with the neoplastic process localization, have a predictive value, trigger the development of metastases. Conclusion: Сhanges in purine metabolism are involved in the pathogenetic patterns of GAC and PAC, reflect the course of the tumor process, are associated with tumor localization and have prognostic significance.

Metabolic Profiling of Thymic Epithelial Tumors Hints to a Strong Warburg Effect, Glutaminolysis and Precarious Redox Homeostasis as Potential Therapeutic Targets

“…In summary: although purine metabolism appears as a potentially interesting oncogenic pathway in TETs (that needs validation in independent cohorts of TETs), it remains enigmatic how the oxypurinol detected in aggressive TETs is generated and whether it is formed inside the tumors themselves. However, since purine metabolites are constituents of tumor-derived exosomes [65] and oxypurinol was recently detected in the blood of non-thymic cancer patients [66], future studies should address the levels of oyxpurinol in TETs and the blood of TET patients with fully monitored medication. Furthermore, future in vitro studies may eventually help to clarify the source of oxypurinol.…”

Early Study of Tumor Abnormal Protein in Gastric Adenocarcinoma

“…3 In Y V Dumanskiy et al's article, purine metabolism disorder was observed in all gastric cancer patients in the experimental group, and the change in uric acid was more obvious in gastric cancer. 4 Therefore, the correlation between TAP and uric acid was analyzed, but the correlation between them was not statistically significant ( Table 5). The impaired balance between clotting and fibrinolysis leads to thrombus formation, and hypercoagulability is a risk factor for aggravating thrombus formation.…”

Unfolding New Roles for Guanine-Based Purines and Their Metabolizing Enzymes in Cancer and Aging Disorders

“…Akin to PNP, HPRT has been used to activate the pro-drug deoxy-6-thioguanosine-5′-triphosphate which is responsible for cell apoptosis due to DNA mispairing (Yan et al, 2003). In a recent study, high levels of circulating uric acid in patients affected by gastric and pulmonary adenocarcinomas has been observed (Dumanskiy et al, 2020).…”