Comparative evaluation of Rauwolfia whole root and reserpine

Abstract

To compare the antihypertensive effect of a Rauwolfia whole root-chlorothiazide combination with reserpine plus chlorothiazide, subjects were selected who had average diastolic pressures of 90 mm. Hg or more at home, in the sitting position. In a double-blind study providing 3 months on each regimen with a 6 week placebo period intervening, no significant difference in antihypertensive effect was demonstrated between the whole root Rauwolfia-chlorothiazide combination and the reserpine plus chlorothiazide.