Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release

Efentakis, M.; Politis, Stavros

doi:10.1016/j.eurpolymj.2005.11.009

Cited by 45 publications

(39 citation statements)

References 16 publications

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“…5a. Biphasic drug release was evident for the tablet which its release surface area was changed (24). When the outer layer was insoluble, S, the surface area around inner tablet, did not alter.…”

Section: Discussionmentioning

confidence: 93%

“…The design of the tablet focused mainly on the controlling surface area of the matrix tablet. Many tablets have been designed to control the surface area for drug release such as the donut or ring shaped (12) or other shapes such as core-in-cup and compressed coated tablets as previously reported (24). The design of tablets in this experiment was based on the restriction of surface area.…”

Section: Discussionmentioning

confidence: 99%

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Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

Phaechamud

Choncheewa

2015

AAPS PharmSciTech

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Abstract. Double-layered matrix tablets prepared from shellac wax-lutrol were fabricated using a molding technique, and the release of hydrochlorothiazide and propranolol HCl from the inner tablet or outer layer was studied. The simultaneous determination of dual drug release was measured with first derivative UV spectrophotometry. The tablet containing shellac wax as the outer tablet and lutrol as the inner tablet showed more appropriate drug release and the size of the inner layer influenced the rate of drug release. In addition, the aqueous solubility of the drug and the components of the inner tablet or outer layer affected the drug release behavior. Most of the double-layered tablets exhibited the drug-release pattern which fitted well with zero-order kinetic due to the restriction of the release surface. Biphasic drug release pattern was found in the tablet of which the outer layer rapidly eroded. The drug dissolution data from drug-loaded-outer layer could predict the dissolution time for the outer layer of drug-loaded inner part of double-layered matrix tablet. Incorporation of lutrol increased the drug release from shellac wax matrix, and the zero-order release was attained by fabricating it into a double-layered tablet.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

Phaechamud

Choncheewa

2015

AAPS PharmSciTech

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“…But this is difficult due to number of physiological problems such as fluctuation in the gastric emptying process, narrow absorption window and stability problem in the intestine. [1][2][3] To overcome this problem, different approaches like bio adhesive systems, floating drug delivery systems, swelling and expanding systems and delayed gastric emptying systems have been proposed to retain the dosage form for a longer duration in stomach. 4,5 Floating dosage forms have a bulk density lower than that of gastric fluids and therefore remain buoyant on the stomach contents to prolong the gastric retention time.…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation

C¹,

Swamiappan²

2016

Adv Pharm Bull

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“…Lately, multi-layer matrix systems are gaining importance in the design of oral sustained drug delivery systems. A multi-layer system consists, usually, of a hydrophilic matrix core containing the active ingredient and one or two impermeable or semi-permeable polymeric coatings (barrier-layer) applied on one or both faces of the core during tabletting (2)(3)(4). The presence of the barrierslayers modifies the hydration/swelling rate of the core and reduces the surface area available for drug release.…”

Section: Introductionmentioning

confidence: 99%

Formulation Study and Evaluation of Matrix and Three-layer Tablet Sustained Drug Delivery Systems Based on Carbopols with Isosorbite Mononitrate

Efentakis

Peponaki

2008

AAPS PharmSciTech

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Abstract. The purpose of this research was to develop and evaluate different preparations of sustained delivery systems, using Carbopols as carriers, in the form of matrices and three-layer tablets with isosorbite mononitrate. Matrix tablets were prepared by direct compression whereas three-layer tablets were prepared by compressing polymer barrier layers on both sides of the core containing the drug. The findings of the study indicated that all systems demonstrated sustained release. The properties of the polymer used and the structure of each formulation appear to considerably affect drug release and its release rate. The three-layer formulations exhibit lower drug release compared to the matrices. This was due to the fact that the barrier-layers hindered the penetration of liquid into the core and modified drug dissolution and release. The geometrical characteristics/structure of the tablets as well as the weight/ thickness of the barriers-layers considerably influence the rate of drug release and the release mechanisms. Kinetic analysis of the data indicated that drug release from matrices was mainly attributed to Fickian diffusion while three-layer tablets exhibited either anomalous diffusion or erosion/relaxation mechanisms. The advantage of Carbopol formulations is that a range of release profiles can easily be obtained through variations in tablet structure and thus Carbopols are appropriate carriers of oral sustained drug delivery systems for soluble drugs such as the isosorbite mononitrate.

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Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release

Cited by 45 publications

References 16 publications

Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation

Formulation Study and Evaluation of Matrix and Three-layer Tablet Sustained Drug Delivery Systems Based on Carbopols with Isosorbite Mononitrate

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