Comparative FISH-mapping of the prion protein gene (PRNP) on cattle, river buffalo, sheep and goat chromosomes

Iannuzzi, L.; Palomba, Raffaele; Meo, G.P. Di; Perucatti, A.; Ferrara, L.

doi:10.1159/000015030

Cited by 20 publications

(20 citation statements)

References 10 publications

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“…The PrP gene in sheep, goats and cattle has been mapped to chromosome 13 [51]. The genomic sequence available around the PrP gene locus is 32 kb in sheep (accession No.…”

Section: Prp Genomics In Sheep Goats Cattle and Deermentioning

confidence: 99%

PrPgenetics in ruminant transmissible spongiform encephalopathies

2008

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-Scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) are prion diseases in ruminants with considerable impact on animal health and welfare. They can also pose a risk to human health and control is therefore an important issue. Prion protein (PrP) genetics may be used to control and eventually eradicate animal prion diseases. The PrP gene in sheep and other representatives of the order Artiodactyles has many polymorphisms of which several are crucial determinants of susceptibility to prion diseases, also known as transmissible spongiform encephalopathies (TSE). This review will present the current understanding of PrP genetics in ruminants highlighting similarity and difference between the species in the context of TSE.

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“…The PrP gene in sheep, goats and cattle has been mapped to chromosome 13 [51]. The genomic sequence available around the PrP gene locus is 32 kb in sheep (accession No.…”

Section: Prp Genomics In Sheep Goats Cattle and Deermentioning

confidence: 99%

PrPgenetics in ruminant transmissible spongiform encephalopathies

2008

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“…The cytogenetic mapping data presented here further extend our knowledge of the genomes of these two economically important species by targeting autosomal loci to specific chromosome regions that were generally devoid of gene assignments (Iannuzzi, 1998;Iannuzzi et al, 1998bIannuzzi et al, , 2000aDi Meo et al, 2000;SheepBase). …”

confidence: 69%

“…In previous studies only PRNP and the cosmid containing the microsatellite IDVGA32 were FISH-mapped on BBU14 and BBU16, respectively (Iannuzzi, 1998;Iannuzzi et al, 1998b), while in sheep only PRNP and IL2RA on OAR13, as well as FSHB on OAR15 were in situ mapped (SheepBase). However, IL2RA was previously assigned to a larger chromosome region covering three chromosome bands instead of a single band as in the present study.…”

Section: Resultsmentioning

confidence: 99%

Twelve loci from HSA10, HSA11 and HSA20 were comparatively FISH-mapped on river buffalo and sheep chromosomes

Iannuzzi

Gallagher²,

Meo³

et al. 2001

Cytogenet Genome Res

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Ten type I loci from HSA10 (IL2RA and VIM), HSA11 (HBB and FSHB) and HSA20 (THBD, AVP/OXT, GNAS1, HCK and TOP1) and two domestic cattle type II loci (CSSM30 and BL42) were FISH mapped to R-banded river buffalo (BBU) and sheep (OAR) chromosomes. IL2RA (HSA10) maps on BBU14q13 and OAR13q13, VIM (HSA10) maps on BBU14q15 and OAR13q15, HBB (HSA11) maps on BBU16q25 and OAR15q23, FSHB (HSA11) maps on BBU16q28 and OAR15q26, THBD (HSA20) maps on BBU14q15 and OAR13q15 while AVP/OXT, GNAS1, HCK, and TOP1 (HSA20) as well as CSSM30 and BL42 map on the same large band of BBU14q22 and OAR13q22. All loci were mapped on the same homologous chromosomes and chromosome bands of the two species, and these results agree with those earlier reported in cattle homologous chromosomes 15 and 13, respectively, confirming the high degree of both banding and physical map similarities among the bovid species. Indirect comparisons between physical maps achieved on bovid chromosomes and those reported on HSA10, HSA11 and HSA20 were performed.

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“…Slide treatment, in situ hybridization, signal detection, RBH-and RBA-banding and image processing were reported earlier (Iannuzzi et al, 1998b).…”

Section: Methodsmentioning

confidence: 96%

Comparative FISH-mapping of six expressed gene loci to river buffalo and sheep chromosomes

Iannuzzi

Gallagher²,

Meo³

et al. 1999

Cytogenet Genome Res

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Six expressed gene loci (NF1, CRYB1, CHRNB1, TP53, P4HB and GH1), recently assigned to cattle chromosome 19 by both radiation hybrid analysis and FISH-mapping, were comparatively FISH-mapped to river buffalo chromosome (BBU) 3p and sheep chromosome (OAR) 11, extending the physical map in these two important bovids. The six loci mapped to the same homoeologous chromosome bands of BBU 3p and OAR 11, and their gene order was centromere–NF1–CRYB1–CHNRB1–TP53–(GH1, P4HB).

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Comparative FISH-mapping of the prion protein gene (PRNP) on cattle, river buffalo, sheep and goat chromosomes

Cited by 20 publications

References 10 publications

PrPgenetics in ruminant transmissible spongiform encephalopathies

PrPgenetics in ruminant transmissible spongiform encephalopathies

Twelve loci from HSA10, HSA11 and HSA20 were comparatively FISH-mapped on river buffalo and sheep chromosomes

Comparative FISH-mapping of six expressed gene loci to river buffalo and sheep chromosomes

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