Comparative Gait Analysis in Progressive Supranuclear Palsy and Parkinson's Disease

Abstract

Background: Although changes to gait are an important clinical feature of progressive supranuclear palsy (PSP), systematic analyses have not been well examined, especially in comparison to Parkinson's disease (PD). Methods: The characteristics of gait in 20 PSP patients (14 males and 6 females) were evaluated in comparison to 124 PD patients (64 males and 60 females) and 24 controls, that is, healthy age-matched adults (5 males and 19 females). Gait in patients was recorded in a 10-m walking test at a self-selected speed. During this time, patients felt most comfortable while wearing a new portable triaxial accelerometer rhythmogram device. Gait variables among the 3 groups were compared. Results: Both PSP and PD patients shared the following similar hypokinetic gait characteristics: decreased velocity, step length, cadence and mean acceleration. Step time and variability in step time were mutually related. However, among the 3 groups, PSP patients showed characteristically low vertical displacement and a higher acceleration than PD patients at the same cadence. Conclusion: Although PSP and PD patients showed similar hypokinetic gait, a reduced vertical displacement characterized walking in PSP patients, differing substantially from the characteristics of walking displayed by PD patients.

Inertial Sensors to Assess Gait Quality in Patients with Neurological Disorders: A Systematic Review of Technical and Analytical Challenges

“…Some studies included and compared several types of disorders: frailty and mild cognitive impairment; Parkinson disease and dementia (Yoneyama et al, 2016); Parkinson disease and peripheral neuropathy (Sejdic et al, 2014); or Parkinson disease and progressive supranuclear palsy (Hatanaka et al, 2016). Most of the other studies aimed at differentiating pathological and healthy participants.…”

Relationship between Amount of Daily Movement Measured by a Triaxial Accelerometer and Motor Symptoms in Patients with Parkinson’s Disease

“…The MIMAMORI-Gait is a portable motion recorder designed for long-term continuous measurement, and has been approved in Japan for clinical assessment of gait disturbance and the amount of movement in patients with various diseases-such as PD, progressive supranuclear palsy, and vascular parkinsonism-and has been confirmed to be useful clinically [12][13][14][15]26]. The present study was carried out to determine the association between the amount of overall movement over the 24 h measured by the MIMAMORI-Gait and motor symptoms of patients with PD assessed at the outpatient clinic by the UPDRS.…”

Discriminating Progressive Supranuclear Palsy from Parkinson’s Disease using wearable technology and machine learning

“…We found just two previous studies looking at gait in PSP. One of these used a single IMU in the lumbar region (8), and detected only a difference in vertical displacement during gait between PSP and PD. The other used two sensors, one attached to each foot (19), and identified significant differences in gait speed and cadence.…”

“…Comparative studies using accelerometers (8) have shown many shared gait abnormalities (9) (10-12) including decreases in velocity, step length, cadence, and mean acceleration. Some differences have also been found, including lower vertical displacement and higher acceleration in PSP.…”