Comparative in vitro activities of SCE-129, sulbenicillin, gentamicin, and dibekacin against Pseudomonas

Cefsulodin sodium (SCE-129, CGP-7174/E), active in minimum inhibitory concentrations (MICs) of 0.5 to 64 ,ug/ml, was about 16-to 32-fold more active than carbenicilhin against Pseudomonas aeruginosa. It was also active against P. diminuta, P. maltophilia, P. paucimobilis, and P. pseudoalcaligenes (MICs of 1 to 32 ug/ml) but not against other species of Pseudomonas or otlher gram-negative bacteria. Except with highly carbenicillin-resistant isolates, MICs of cefsulodin for P. aeruginosa were little affected by an increase in the inoculum. With a small inoculum, minimum bactericidal concentrations (MBCs) were the same as or twice the MIC, but increasing the inoculum had a greater effect on the MBC than on the MIC. Cefsulodin was not hydrolyzed by the ,B-lactamase induced in P. aeruginosa by growth in the presence of benzylpenicillin and was a poor substrate for,-lactamases from Enterobacter cloacae and Proteus morganii. However, it was hydrolyzed, albeit slowly, by the /i-lactamase produced by most of our highly carbenicillin-resistant isolates of P. aeruginosa and by TEM-type f8-lactamases.Cefsulodin sodium, previously known as SCE-129 and CGP-7174/E, is a new cephalosporin active against Pseudomonas aeruginosa (12). In this paper we report studies ofits activity against P. aeruginosa and a range of other gram-negative bacteria, and also studies ofits susceptibility to hydrolysis by various ,B-lactamases. MATERIALS AND METHODSBacteria studied. We studied P. aeruginosa (131 isolates), P. acidovorans (12 isolates), P. cepacia (12 isolates), P. diminuta (1 isolate), P. fluorescens (13 isolates), P. maltophilia (10 isolates), P. paucimobilis (3 isolates), P. pseudoalcaligenes (1 isolate), P. putida (27 isolates), P. putrefaciens (1 isolate), P. stutzeri (1 isolate), Acinetobacter anitratus (10 isolates

contrasting

confidence: 53%

In vitro antibacterial activity and susceptibility of cefsulodin, an antipseudomonal cephalosporin, to beta-lactamases

King¹,

Shannon²,

Phillips³

1980

“…Cefsulodin (formerly SCE-129) is a cephalosporin which has in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, and most other gram-positive cocci (4,(7)(8)(9). However, it has very little activity against the enterococci and members of the Enterobacteriaceae (7)(8)(9).…”

mentioning

confidence: 99%

“…However, it has very little activity against the enterococci and members of the Enterobacteriaceae (7)(8)(9). Such a limited-spectrum antimicrobial agent may be advantageous when treating bacterial infections of known etiology.…”

mentioning

confidence: 99%

Cefsulodin: antibacterial activity and tentative interpretive zone standards for the disk susceptibility test

Barry¹,

Jones²,

Thornsberry³

1981

Cefsulodin (formerly SCE-129) is a cephalosporin which has in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, and most other gram-positive cocci (4, 7-9). However, it has very little activity against the enterococci and members of the Enterobacteriaceae (7-9). Such a limited-spectrum antimicrobial agent may be advantageous when treating bacterial infections of known etiology.In the present report we compare cefsulodin with four penicillins with antipseudomonal activity (carbenicillin, ticarcillin, mezlocillin, and piperacillin). For this purpose, 778

“…The activity of cefsulodin against sulbenicillin-and carbenicillin-resistant strains of P. aeruginosa, however, is inferior to that against susceptible strains (12). Furthermore, it has been reported by Tsuchiya et al (13) that the activity of cefsulodin is greater in vivo than in vitro.…”

Section: Cefsulodin [3-(4-carbamoyl-l-pyridiniomethyl) -78-(d-a-sulfmentioning

confidence: 96%

“…In mice infected with sulbenicillin-and gentamicin-susceptible strains, cefsulodin was about 12 to 60 times more active than sulbenicillin and had an activity similar to gentamicin. In mice, the activity of cefsulodin was independent whether the strains were resistant to gentamicin or not, but it was considerably affected by resistance of the strains to sulbenicillin.…”

mentioning

confidence: 93%

Comparative In Vivo Activities of Cefsulodin, Sulbenicillin, and Gentamicin Against Pseudomonas aeruginosa

Kondo

Tsuchiya

1978

The in vivo activities of cefsulodin, sulbenicillin, and gentamicin were compared in mice infected intraperitoneally with Pseudomonas aeruginosa . In mice infected with sulbenicillin- and gentamicin-susceptible strains, cefsulodin was about 12 to 60 times more active than sulbenicillin and had an activity similar to gentamicin. In mice, the activity of cefsulodin was independent whether the strains were resistant to gentamicin or not, but it was considerably affected by resistance of the strains to sulbenicillin.