Comparative neuroprotective effects of native curcumin and its galactomannoside formulation in carbofuran-induced neurotoxicity model

Safety assessment of a highly bioavailable curcumin-galactomannoside complex (CurQfen) in healthy volunteers, with a special reference to the recent hepatotoxic reports of curcumin supplements: A 90-days prospective study

“…Once swell in the gastrointestinal tract, CGM has been shown to act as a self-emulsifying hydrogel with high mucoadhesive character, capable of delivering amphiphilic colloidal curcumin particles that can be absorbed quickly. CGM has already demonstrated its superior efficacy in a relatively low dosage [ [32] , [33] , [34] ], with improved brain bioavailability as revealed by its influence on brain waves [ 35 ], radioprotective [ 36 ] and neuroprotective effects [ 37 , 38 ]. CGM was reported to exhibit 45-fold enhancement in the bioavailability of free curcuminoids and 270-fold enhancement in the bioavailability of total curcuminoids (sum of conjugated and unconjugated), when compared to an equivalent dose of unformulated standard curcuminoids with 95 % purity [ 31 ].…”

Neurodevelopmental toxicity of bisphenol AF in zebrafish larvae and the protective effects of curcumin

“…Previous studies showed that CUR could protect the integrity of the blood–brain barrier and showed beneficial effects against nerve injuries (Wu et al, 2021). Further, CUR has been shown to prevent neuro‐toxicities induced by different toxic agents, such as carbofuran, deltamethrin, and 5‐fluorouracil by reduction of inflammatory cytokines, antioxidant, and antiapoptotic effects (Gelen et al, 2021; Sindhu et al, 2020; Zaki et al, 2020). However, whether CUR could show protective effects against BPAF is still unclear.…”