Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats

Xu, Ping; Li, Ying; Du, Shouying; Lu, Yang; Bai, Jie; Guo, Qing-li

doi:10.1631/jzus.b1300141

Cited by 16 publications

(18 citation statements)

References 27 publications

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“…These data indicated that some ingredients in GSC but not eugenol could suppress resorption and reduce the bioavailability of bicyclic monoterpenes. It was reported that the absorption of borneol was inhibited and elimination time was increased in another Chinese formula Xingnaojing , which were similar to our results. An enzyme experiment in vitro indicated that CYP3A4 was one of the main enzymes involved in the metabolism of borneol and isoborneol.…”

Section: Resultssupporting

confidence: 92%

“…Under the two different delivery methods of oral and intravenous injection, the pharmacokinetics of eugenol in rats were examined by means of LC–MS/MS method . Some methods based on GC or GC–MS have been reported for the detection of bicyclic monoterpenes in biological samples . However, there is still no method established for simultaneous determination of the four ingredients mentioned above for pharmacokinetic investigations.…”

Section: Introductionmentioning

confidence: 99%

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Vortex‐ultrasound‐assisted dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry for the analysis of volatile bioactive components and comparative pharmacokinetic study of the herb–herb interactions in Guanxin Shutong Capsule

Gao

et al. 2017

J of Separation Science

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Guanxin Shutong Capsule, an effective traditional Chinese medicine, is widely used for coronary heart disease clinically. Volatile components are one of its important bioactive constituents. To better understand the material basis for the therapeutic effects, the components of Guanxin Shutong Capsule absorbed into the blood and their metabolites were identified based on gas chromatography with mass spectrometry coupled with vortex-ultrasound-assisted dispersive liquid-liquid microextraction. As a result, three prototypes and 15 metabolites were identified or tentatively characterized in rat plasma. Subsequently, a pharmacokinetic study was carried out to monitor the concentrations of the main bioactive constituents and metabolites (isoborneol, borneol, eugenol, and camphor) by gas chromatography with mass spectrometry in rat plasma following oral administration of single herb extract and different combinations of herbs in this prescription. Compared to other groups, a statistically significant difference of the pharmacokinetic properties was obtained when the total complex prescription was administered, indicating possible drug-drug interactions among the complex ingredients of Guanxin Shutong Capsule. These findings provided an experimental basis concerning the clinical application and medicinal efficacy of Guanxin Shutong Capsule in the treatment of coronary heart disease.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Vortex‐ultrasound‐assisted dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry for the analysis of volatile bioactive components and comparative pharmacokinetic study of the herb–herb interactions in Guanxin Shutong Capsule

Gao

et al. 2017

J of Separation Science

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“…For investigating the role of (+)-borneol in permanent cerebral ischemia, 45 male Sprague-Dawley rats were randomly divided into the sham group, the vehicle-treated group and the (+)-borneol-treated groups (1.0 mg/kg), with 15 rats in each group. The terminal half-life (t 1/2 ) of borneol was 2 h following cerebral ischemia-reperfusion [ 16 ] . We subjected the rats to pMCAO and administered drugs by tail intravenous injection 2 hours and 5 hours after pMCAO, respectively.…”

Section: Resultsmentioning

confidence: 99%

(+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines

Chang¹,

Yin²,

Wu³

et al. 2017

J Biomed Res

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Stroke is one of the leading causes of disability and death globally. It occurs when a major artery is occluded in the brain and leads to death of cells within the injured tissue. (+)-Borneol, a simple bicyclic monoterpene extracted from traditional Chinese medicine, is widely used in various types of diseases. However, no study has proved the effects of (+)-borneol on functional recovery from permanent ischemic stroke and the mechanism is still unknown. Here, we report that in the rat model of permanent cerebral ischemia, we found that (+)-borneol (1.0 mg/kg) significantly ameliorated infarct size and neurological scoresvia reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in a dose dependent manner. Notably, (+)-borneol showed long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreased the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. These findings suggest that (+)-borneol could serve as a therapeutic target for ischemic stroke.

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“…But none of them was administrated intranasally. Xu [19] studied the pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats after oral administration. Significant rise were observed on AUC and C max , but there were no differences between two groups on T 1/2 .…”

Section: Discussionmentioning

confidence: 99%

In Vivo Pharmacokinetics of Puerarin via Different Drug Administration Routes Based on Middle Cerebral Artery Occlusion Model

Bai

Dong

et al. 2016

Eur J Drug Metab Pharmacokinet

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Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats

Abstract: These results suggest that the pathological damages of ischemia-reperfusion have a significant impact on the pharmacokinetic traits of borneol and that there are some components in XNJ inhibiting the absorption of borneol.

Cited by 16 publications

References 27 publications

Vortex‐ultrasound‐assisted dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry for the analysis of volatile bioactive components and comparative pharmacokinetic study of the herb–herb interactions in Guanxin Shutong Capsule

Vortex‐ultrasound‐assisted dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry for the analysis of volatile bioactive components and comparative pharmacokinetic study of the herb–herb interactions in Guanxin Shutong Capsule

(+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines

In Vivo Pharmacokinetics of Puerarin via Different Drug Administration Routes Based on Middle Cerebral Artery Occlusion Model

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