Comparative Review of Recently Introduced Oral Contraceptives Containing Norgestimate, Desogestrel, and Gestodene and Older Oral Contraceptives

Schwend, Thomas H.; Lippman, Joel

doi:10.1007/978-1-4612-4096-9_10

Cited by 4 publications

(1 citation statement)

References 79 publications

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“…Steroidal estrogens are placed in a Group 1 as carcinogenic to humans, on the basis of sufficient evidence of carcinogenicity in humans [10]. Ethinylestradiol is used with various progestogens, in combined oral contraceptive formulations [11]. There are sufficient evidences for the carcinogenicity of ethinylestradiol in experimental animals [12].…”

Section: Introductionmentioning

confidence: 99%

Effect ofCentella asiaticaL. extract against ethinylestradiol-induced geno-toxic damage on cultured human lymphocytes

Siddique¹,

Beg²,

Afzal³

2009

Biomed Res

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In this study the effect of Centella asiatica L. extract was studied against genotoxic doses of ethinylestradiol on human lymphocytes culture. The different doses of C. asiatica L. extract i.e. 1.075x10 -4 , 2.125x10 -4 and 3.15x10 -4 g/ml were treated separately with 5 µM of ethinylestradiol. Similar treatments were given with 10 µM of ethinylestradiol. The treatments result in a significant dose dependent decrease in chromosomal aberrations and sister chromatid exchanges on human lymphocyte cultures induced by 5 and 10 µM of ethinylestradiol. The selected doses of C. asiatica L. extract were not genotoxic itself. Hence it is concluded that C. asiatica L. extract reduced the genotoxic damage during the ethinylestradiol therapy in patients and thereby reducing the chances of cancer development in humans.

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Section: Introductionmentioning

confidence: 99%

Effect ofCentella asiaticaL. extract against ethinylestradiol-induced geno-toxic damage on cultured human lymphocytes

Siddique¹,

Beg²,

Afzal³

2009

Biomed Res

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Genotoxic potential of ethinylestradiol in cultured mammalian cells

Siddique

Beg

Afzal

2005

Chemico-Biological Interactions

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Protective role of Eclipta alba L. extract against ethinylestradiol induced genotoxic damage in cultured human lymphocytes

Siddique

Ara²,

Beg³

et al. 2011

Altern Med Studies

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In India, natural preparations derived from plants are widely used for the treatment of various diseases. Hence it becomes necessary to assess the modulating action of the plant extracts when associated with other substances. Ethinylestradiol is not only a genotoxic agent but also a tumor initiating agent. It is widely used in oral contraceptive formulations and also for the treatment of various sexual and metabolic disorders. In the present study, the antigenotoxic effect of Eclipta alba was evaluated against the genotoxic effect induced by 10 μM of ethinylestradiol in the presence of metabolic activation using mitotic index (MI), chromosomal aberrations, sister chromatid exchanges and replication index (RI) as parameters. The treatment of 10 μM of ethinylestradiol along with 1.02x10–4, 2.125x10–4, 3.15x10–4 and 4.17x10–4 g/mL of Eclipta alba (E. alba) extract in culture medium results in a significant dose dependent decrease in the genotoxic effects induced by the treatment of 10 μM of ethinylestradiol. The results of the present study suggest that the plant extract per se does not have genotoxic potential, but can modulate the genotoxicity of ethinylestradiol in cultured human lymphocytes

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Comparative Review of Recently Introduced Oral Contraceptives Containing Norgestimate, Desogestrel, and Gestodene and Older Oral Contraceptives

Cited by 4 publications

References 79 publications

Effect ofCentella asiaticaL. extract against ethinylestradiol-induced geno-toxic damage on cultured human lymphocytes

Effect ofCentella asiaticaL. extract against ethinylestradiol-induced geno-toxic damage on cultured human lymphocytes

Genotoxic potential of ethinylestradiol in cultured mammalian cells

Protective role of Eclipta alba L. extract against ethinylestradiol induced genotoxic damage in cultured human lymphocytes

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