Comparative sequence analysis of the inverted terminal repetition in the genomes of animal and avian adenoviruses

Shinagawa, Morikazu; Ishiyama, Toshiro; Padmanabhan, R.; Fujinaga, Kei; Kamada, Masanobu; Sato, Gihei

doi:10.1016/0042-6822(83)90221-0

Cited by 35 publications

(9 citation statements)

References 18 publications

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“…Most of the published CAV-1 sequences show little difference from that of CAV-1 strain RI261 DNA. The ITR of strain RI261 has a 38 bp deletion relative to that of strain CLL (Sira et al, 1987), and this includes removal of a 35 bp repeat region, whereas the ITRs reported by Shinagawa et al (1983) and Spibey et al (1989) show only minor differences from those of strain RI261. Differences in coding regions between strain RI261 and published sequences result in the loss of one phenylalanine residue at position 5 from a stretch of four phenylalanines in the E3 22n2 kDa protein (ORF 23) relative to the published sequences of Linne (1992) and Dragulev et al (1991), two non-conservative amino acid changes in this protein (Linne, 1992) and four non-conservative amino acid changes in the fibre (ORF 25) (Dragulev et al, 1991).…”

Section: Comparison With Published Cav-1 Sequencesmentioning

confidence: 98%

“…Whether this fusion protein remains functional is not known ; however, given the immunomodulatory role of E3 in human adenoviruses (reviewed by Wold et al, 1994), a loss of biological activity as a result of this deletion could account for the decreased pathogenicity of strain CLL (Dragulev et al, 1991). Strain CLL also has a duplication of the NF-1 binding site in the ITR that is not found in strains RI261, Woc-4 (Shinagawa et al, 1983) and the field isolate described by Spibey et al (1989), which could affect DNA replication.…”

Section: Comparison With Published Cav-1 Sequencesmentioning

confidence: 99%

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Complete DNA sequence of canine adenovirus type 1.

Morrison

Onions

Nicolson

1997

Journal of General Virology

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Section: Comparison With Published Cav-1 Sequencesmentioning

confidence: 98%

Section: Comparison With Published Cav-1 Sequencesmentioning

confidence: 99%

Complete DNA sequence of canine adenovirus type 1.

Morrison

Onions

Nicolson

1997

Journal of General Virology

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“…The CELO virus genome is a linear, doublestranded DNA molecule with the DNA condensed within the virion by virus-encoded core proteins (45,48). The CELO virus genome has covalently attached terminal proteins (46) and has inverted terminal repeats (ITRs), although they are shorter than the mammalian ITRs (4,68). CELO virus encodes a protease with 61 to 69% homology to the mammalian adenovirus proteases (12).…”

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confidence: 99%

The complete DNA sequence and genomic organization of the avian adenovirus CELO

Chiocca

Kurzbauer

Schaffner

et al. 1996

J Virol

200

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The complete DNA sequence of the avian adenovirus chicken embryo lethal orphan (CELO) virus (FAV-1) is reported here. The genome was found to be 43,804 bp in length, approximately 8 kb longer than those of the human subgenus C adenoviruses (Ad2 and Ad5). This length is supported by pulsed-field gel electrophoresis analysis of genomes isolated from several related FAV-1 isolates (Indiana C and OTE). The genes for major viral structural proteins (IIIa, penton base, hexon, pVI, and pVIII), as well as the 52,000-molecular-weight (52K) and 100K proteins and the early-region 2 genes and IVa2, are present in the expected locations in the genome. CELO virus encodes two fiber proteins and a different set of the DNA-packaging core proteins, which may be important in condensing the longer CELO virus genome. No pV or pIX genes are present. Most surprisingly, CELO virus possesses no identifiable E1, E3, and E4 regions. There is 5 kb at the left end of the CELO virus genome and 15 kb at the right end with no homology to Ad2. The sequences are rich in open reading frames, and it is likely that these encode functions that replace the missing E1, E3, and E4 functions.

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“…The CELO virus genome is a doublestranded DNA molecule 43,804 bp in length (13) (GenBank accession no. U46933) and has inverted terminal repeats (ITRs) that are shorter than mastadenovirus ITRs (3,4,51,53). As in human adenovirus, a terminal protein (TP) is covalently attached to the 5Ј terminus of the CELO virus genome (33).…”

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confidence: 99%

Transcriptional Organization of the Avian Adenovirus CELO

Payet¹,

Arnauld²,

Picault³

et al. 1998

J. Virol.

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A detailed map of the transcriptional organization of the CELO virus genome was produced. Recent computer analysis of CELO virus has indicated the presence of 38 putative open reading frames (ORFs). This study, based on analysis of the transcriptional products of CELO in vitro, confirmed the presence of RNAs for 26 of these 38 ORFs. All of the results were obtained by cDNA isolation or specific reverse transcriptase PCR. Observation of ORF transcription kinetics postinfection revealed the existence of early and late expression, with the earliest starting at 2 h postinfection. The 5′ untranslated regions of some RNAs were also studied, and this revealed the existence of a bipartite leader sequence, comparable in structure to the tripartite leader of mastadenovirus. The leader most probably involved in transcriptional activity was observed in most of the structural protein genes of the CELO virus genome. This suggests some homology in transcriptional organization between the avian adenovirus CELO and known mastadenoviruses such as human adenovirus.

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Comparative sequence analysis of the inverted terminal repetition in the genomes of animal and avian adenoviruses

Cited by 35 publications

References 18 publications

Complete DNA sequence of canine adenovirus type 1.

Complete DNA sequence of canine adenovirus type 1.

The complete DNA sequence and genomic organization of the avian adenovirus CELO

Transcriptional Organization of the Avian Adenovirus CELO

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