Comparative Serological Responses and Protection Conferred by Vaccination with V₄HR and BCRDV in Chickens

Abstract

The serological responses and protection of Sonali breed chickens with Australian Newcastle disease V4 heat resistant (NDV4HR) live freeze-dried vaccine (Australian Webster Pvt. Ltd., Sydney) was compared with that of locally produced conventional Lentogenic F-strain Baby Chick Ranikhet Disease vaccine (BCRDV, DLS, Dhaka) of Bangladesh. Thirty day-old chicks were purchased from Mirpur Govt. Poultry Farm, Dhaka and maintained hygienically with commercial feed and water supply ad libitum during the experimental period from November 2002 to January 2003. These birds were divided into three groups (A, B and C), each consisting of 10 birds. Each birds of group A was vaccinated with NDV4HR and group B with BCRDV intraocularly, primary vaccination at 7 days and booster vaccination at 28 days of age, whereas the birds of group C kept as control. Sera samples of each of the bird of all the three groups were collected at 14 days of post-vaccination following each of the primary and booster vaccination at 23 and 44 days of age of birds. Each of the serum sample of all the three groups of birds was titrated by using haemagglutination inhibition (HI) test and results recorded that both the NDV4HR (32.49 ± 23.94) and BCRDV (28.28 ± 10.54) produced more or less similar serological response at two weeks after booster vaccination. The results of challenged experiment showed that the NDV4HR vaccine ( 80% ) apparently conferred higher protection to birds than the BCRDV vaccine (70%). Therefore both the vaccines may be recommended to control ND in commercial chickens but NDV4HR vaccine could provide a practical method of control ND in rural scavenging chickens. Key words: Serological responses, F-strain (BCRDV) NDV4HR vaccine, HI antibody titre, protection, chickens DOI = 10.3329/bjvm.v1i1.1913 Bangl. J. Vet. Med. ( 2003 ). 1 (1) : 25 - 27

Biological characterization and determination of comparative efficacy of an inactivated Newcastle disease virus vaccine prepared from velogenic strain

“…This lower level of antibody production was due to presence of high level of maternally derived antibody (MDA) as the chicks used in this study had comparatively high MDA (Sarkar et al, 2012;Cornax et al, 2012;Kapczynski et al, 2012). On the other hand, HI antibody titre of chickens after secondary vaccination increased significantly (P <0.01, day 27 versus day 55) and similar finding were reported by other investigators (Sarkar et al, 2012;Kafi et al, 2003;Shuaib et al, 2003). The mean ±SE of HI titre at 72 days of age (16 days after tertiary vaccination) of chickens of group C (vaccinated with RDV) indicated that serum antibody level of chickens (Group C) was increased significantly (P <0.001, day 55 versus day 72) following tertiary vaccination at 56 days of age (Sarkar et al, 2012;Banu et al, 2009;Chowdhury et al, 1981).…”

Immune response and protective potential following vaccination against Newcastle disease virus and fowl cholera in Naked neck chickens

“…Antibody titre was sharply increased after primary vaccination with BCRDV and secondary vaccination with RDV. Similar findings were found by several investigators (Chowdhury et al, 1981;Kafi et al, 2003;Sarker et al, 2012). …”

Determination of immune response of Newcastle disease virus vaccines in layer chickens

“…So, cloned 30 might not immunogenic than other strains (B and LaSota strains). Kafi et al (2003) found the highest HI titres after secondary vaccination with BCRDV. Shuaib et al 2003) reported that secondary vaccination yielded HI titres that was significantly higher than the HI titres after single vaccination.…”

“…However Kafi et al (2003) reported that administration of live lentogenic vaccine followed by inactivated killed vaccine would produced durable immunity.…”